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QTL Detection for Rice Grain Shape Using Chromosome Single Segment Substitution Lines 被引量:4
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作者 sheng-qiang li Guo-kun CUI +2 位作者 Cheng-ran GUAN Jun WANG Guo-hua liANG 《Rice science》 SCIE 2011年第4期273-278,共6页
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西妥昔单抗不同给药策略对RAS野生型CRC肝转移患者缓解率及MMPs、miR-106b-5p、PCAT-1、不良反应的影响 被引量:1
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作者 王超 李胜强 赵岩 《世界华人消化杂志》 CAS 2022年第4期204-211,共8页
背景结直肠癌在发病初期并无明显的临床症状,在临床确诊时往往已处于病理晚期,发生了远处转移.结直肠癌最常见的远处转移器官是肝脏,研究发现,采用生物靶向药物联合FOLFIRI方案对发生肝转移患者可取得良好的疗效.目的探讨西妥昔单抗不... 背景结直肠癌在发病初期并无明显的临床症状,在临床确诊时往往已处于病理晚期,发生了远处转移.结直肠癌最常见的远处转移器官是肝脏,研究发现,采用生物靶向药物联合FOLFIRI方案对发生肝转移患者可取得良好的疗效.目的探讨西妥昔单抗不同给药策略在RAS野生型结直肠癌(colorectal cancer,CRC)肝转移患者中的应用价值及安全性.方法选取2017-07/2019-03我院74例采用FOLFOX化疗方案治疗的RAS野生型CRC肝转移患者作为研究对象,根据西妥昔单抗给药策略分为2组,每组37例.单周组:首次予以400 mg/m^(2)西妥昔单抗,静脉滴注120 min,后续每周予以250 mg/m^(2)西妥昔单抗,1周/次;双周组:予以500 mg/m^(2)西妥昔单抗治疗,每2周重复.观察对比两组疾病缓解率、毒副反应发生率、生存质量改善率、生存情况及治疗前后基质金属蛋白酶(matrix metalloproteinase,MMPs)、miR-106b-5p、前列腺癌相关非编码RNA转录物1(PCAT-1)表达.结果双周组疾病缓解率78.38%高于单周组54.05%(P<0.05);双周组白细胞和/或中性粒细胞减少、口腔黏膜炎及痤疮样皮疹发生率均高于单周组(P<0.05);双周组MMP-2、MMP-9相对表达量均较单周组显著下降,基质金属蛋白酶组织抑制因子(tissue inhibitor of metalloproteinase,T1MP)表达量较单周组明显升高(P<0.05);单周组与双周组的miR-106b-5p、PCAT-1相对表达量均较治疗前显著下降,且双周组下降幅度更大(P<0.05);双周组生存质量改善有效率72.97%高于单周组48.65%(P<0.05);两组无进展生存时间相比,差异无统计学意义(P>0.05).结论西妥昔单抗双周给药治疗RAS野生型CRC肝转移患者缓解率、生存质量改善情况优于每周给药,但会增加患者不良反应发生率,实际可根据患者耐受情况选择治疗方案. 展开更多
关键词 西妥昔单抗 结直肠癌 肝转移 RAS野生型 缓解率 基质金属蛋白酶 前列腺癌相关非编码RNA转录物
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A versatile electrostatic trap with open optical access 被引量:2
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作者 李胜强 印建平 《Frontiers of physics》 SCIE CSCD 2018年第2期51-57,共7页
A versatile electrostatic trap with open optical access for cold polar molecules in weak-field-seeking state is proposed in this paper. The trap is composed of a pair of disk electrodes and a hexapole. With the help o... A versatile electrostatic trap with open optical access for cold polar molecules in weak-field-seeking state is proposed in this paper. The trap is composed of a pair of disk electrodes and a hexapole. With the help of a finite element software, the spatial distribution of the electrostatic field is calculated. The results indicate that a three-dimensional closed electrostatic trap is formed. Taking NDa molecules as an example, the dynamic process of loading and trapping is simulated. The results show that when the velocity of the molecular beam is 10 m/s and the loading time is 0.9964 ms, the maximum loading efficiency reaches 94.25% and the temperature of the trapped molecules reaches about 30.3 inK. A single well can be split into two wells, which is of significant importance to the precision measurement and interference of matter waves. This scheme, in addition, can be further miniaturized to construct one-dimensional, two-dimensional, and three-dimensional spatial electrostatic lattices. 展开更多
关键词 atomic and molecular physics electrostatic trap cold polar molecules finite elementanalysis
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