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多西他赛联合PD-1/PD-L1抑制剂二线治疗晚期非小细胞肺癌的临床分析 被引量:15
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作者 陈青 李艳 +4 位作者 张文杰 杨圣杰 王晨 郭其森 史文娜 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第9期605-612,共8页
背景与目的程序性死亡受体1(programmed cell death 1, PD-1)/程序性死亡配体1(programmed cell death ligand 1, PD-L1)抑制剂和多西他赛作为晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的标准二线治疗方案,治疗效果有... 背景与目的程序性死亡受体1(programmed cell death 1, PD-1)/程序性死亡配体1(programmed cell death ligand 1, PD-L1)抑制剂和多西他赛作为晚期非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的标准二线治疗方案,治疗效果有限。多西他赛联合PD-1/PD-L1抑制剂是否能增加疗效并使患者更好地获益少有报道。本研究旨在探索多西他赛联合PD-1/PD-L1抑制剂二线治疗驱动基因阴性的IV期NSCLC的临床疗效和安全性。方法选取2018年10月1日-2020年12月31日在山东省肿瘤医院就诊的IV期NSCLC患者118例,依据治疗方法不同分为观察组(n=69)和对照组(n=49),观察组患者接受多西他赛联合PD-1/PD-L1抑制剂治疗,对照组患者接受PD-1/PD-L1抑制剂治疗,比较两组患者的临床疗效及3级以上不良反应发生情况。结果观察组疾病控制率(disease control rate,DCR)(89.9%)高于对照组(73.5%)(P=0.019),客观缓解率(objective response rate, ORR)(24.6%)与对照组(16.3%)比较差异无统计学意义(P=0.276)。随访至2021年6月22日,观察组中位无进展生存时间(progression-free survival, PFS)(7.17个月)长于对照组(4.43个月)(P=0.027)。观察组1年无进展生存率为15.6%,对照组为7.7%,差异无统计学差异(P=0.205)。治疗期间两组不良反应多为1级-2级,均可耐受,观察组患者骨髓抑制发生率高于对照组(P<0.05),余不良反应与对照组无统计学差异。Cox回归分析结果显示体能状态(performance status, PS)(P=0.020)及年龄(P=0.049)是多西他赛联合PD-1/PD-L1抑制剂治疗效果的独立预后因素。结论驱动基因阴性IV期NSCLC患者应用多西他赛联合PD-1/PD-L1抑制剂二线治疗可提高疾病控制率,延长无进展生存时间,不良反应可耐受。 展开更多
关键词 肺肿瘤 多西他赛 PD1/PD-L1抑制剂 安全性 近期疗效
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Optimization of Load Balancing Algorithm for Virtual Machine Dynamic Migration under Mobile Cloud Computing
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作者 Weijin Jiang Fang Ye +3 位作者 shengjie yang Wei Liu Xiaoliang Liu Sijian Lv 《China Communications》 SCIE CSCD 2020年第6期237-245,共9页
As one of the key technologies of cloud computing,the virtualization technology can virtualize all kinds of resources and integrate them into the unified planning of the cloud computing management platform.The migrati... As one of the key technologies of cloud computing,the virtualization technology can virtualize all kinds of resources and integrate them into the unified planning of the cloud computing management platform.The migration of virtual machines is one of the important technologies of virtual machine applications.However,there are still many deficiencies in the implementation of load balancing by virtual machine dynamic migration in cloud computing.Traditional triggering strategy thresholds are mostly fixed.If there is an instantaneous peak,it will cause migration,which will cause a waste of resources.In order to solve this problem,based on improving the dynamic migration framework,this paper proposes node selection optimization algorithm and node load balancing strategy and designs a prediction module,which uses a one-time smooth prediction to avoid the shortcoming of peak load moment.The simulation experiments and conclusions analysis results show that the fusion algorithm has performance advantages obvious. 展开更多
关键词 cloud computing dynamic migration load balance node selection load value prediction
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Risk Identification and Protection during High-Risk Forensic Autopsy
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作者 Xia Liu Jilong Zheng +2 位作者 shengjie yang Cunrui Wei Xuesong Feng 《Journal of Forensic Science and Medicine》 2020年第2期75-77,共3页
"High-risk"autopsies are those in which the anatomical examination of a corpse entails a substantial risk of contracting a serious infectious disease.Herein,we discuss the risks of infection associated with ... "High-risk"autopsies are those in which the anatomical examination of a corpse entails a substantial risk of contracting a serious infectious disease.Herein,we discuss the risks of infection associated with high-risk autopsies and factors pertaining to risk identification in high-risk autopsies,and we suggest potentially preventative measures focused on anatomy room protection and virtual imaging. 展开更多
关键词 Forensic pathology high-risk autopsy infectious disease preventative measure
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