Effect of aerobic exercise on insulin resistance and centra1 adiposity disappeared after the discontinuation of intervention in overweight women

Purpose： This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance （HOMA-IR） are maintained after discontinuation of intervention in the overweight/obese （OWOB） women. Methods： The study subjects were from 2 independent studies with similar aerobic exercise （AE） intervention programs. In study I, I50WOB postmenopausal women with pre-diabetes （body mass index, BMI = 24-33 kg/m2, aged 52-65 years） completed an 8-month exercise intervention and were followed for 2 years after the intervention. In study lI, 12 OWOB （BM1 = 25-35 kg/m2, aged 30-50 years） premenopausal women participated in a 6-week AE and were followed for 4 years after the intervention. The exercise program consisted of progressive AE with intensity of 60%-75% of initial fitness level, 30-60 min/time and 3-5 times/week. Fat mass （FM） was assessed by Dual Energy X-ray Absorptiometry （DXA Prodigy; study I） or bioelectrical impedance device （Inbody 720; study II）. Plasma glucose and insulin were assessed by chemiluminescent immunoassay and HOMA-IR was calculated. Results： Both 8-month and 6-week moderate AE were effective in reducing HOMA-IR （-18.9%, p = 0.012 and -26.7%, p = 0.046, respectively）, and 8-month AE reduced FM at upper abdominal region （-6.2%, p = 0.021）. However, these improvements were not maintained in either study at the follow-up. Conclusion： The AE program used in these studies was effective to reduce insulin resistance and/or FM in central body region among overweight and obese women. However, when exercise intervention was discontinued, the beneficial effects following both short- and long-term intervention disappeared. Thus maintaining exercise seems to be required if one wants to reap the benefits of exercise in the long-term.

Assessment of sleep disturbances with the athlete sleep screening questionnaire in Chinese athletes

This study investigated the factors that are associated with sleep disturbances among Chinese athletes.Sleep quality and associated factors were assessed by the Athlete Sleep Screening Questionnaire(ASSQ,n?394,aged 18–32 years,47.6%female).Sleep difficulty score(SDS)and level of sleep problem(none,mild,moderate,or severe)were used to classify participants'sleep quality.Categorical variables were analyzed by Chi-square or fisher's exact tests.An ordinal logistic regression analysis was used to explore factors with poor sleep(SDS8).Approximately 14.2%of participants had moderate to severe sleep problem(SDS8).Fifty-nine percent of the athletes reported sleep disturbance during travel,while 43.3%experienced daytime dysfunction when travelling for competition.No significant difference was found in the SDS category between gender,sports level and events.Athletes with evening chronotype were more likely to report worse sleep than athletes with morning and intermediate chronotype(OR,2.25;95%CI,1.44–3.52;p<0.001).For each additional year of age,there was an increase of odds ratio for poor sleep quality(OR,1.15;95%CI,1.04–1.26;p?0.004),while each additional year of training reduced the odds ratio(OR,0.95;95%CI,0.91–0.99;p?0.044).To improve sleep health in athletes,chronotype,travel-related issues,age and years of training should be taken into consideration.

Effects of exercise and dietary interventions on serum metabolites in men with insomnia symptoms:A 6-month randomized controlled trial

Accumulating evidence show that exercise and diet interventions are associated with improved sleep quality.Studies investigating the effects of exercise and dieting on circulating metabolomics in people with sleep disorders,particularly insomnia,are scarce.This 6-month randomized study aimed to assess the effects of exercise and dietary interventions on serum metabolites in men with insomnia symptoms.Seventy-two Finnish men(age:51.6±10.1 years)with chronic insomnia symptoms who were assigned to different intervention groups completed this study(exercise,n=24;diet,n=27;and control,n=21).The Shapiro-Wilk W-test,Levene test,Spearman correlation analysis,and analysis of variance were used for data analysis.We found that exercise and diet intervention were associated with improved sleep quality and with a number of metabolites across different biochemical pathways.Although we could not show causality,our findings provide new insight into the biological mechanisms underlying the health effects of physical activity,diet,and sleep quality.Further investigation is needed to better understand the link among lifestyle,sleep quality,and metabolic health.

Exercise precision medicine for type 2 diabetes:Targeted benefit or risk?

Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metformin and exercise treatment may have neither additive effect nor even cause adverse effects in T2D patients.This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment.A 67-years old woman was followed-up for five months,including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin.The findings were four-fold:1)During a high-intensity interval training bout,blood glucose systematically decreased,while blood lactate concentrations fluctuated randomly;2)Basal blood lactate levels were well above 2 mmol/L on days with medication only;3)Combined exercise and metformin administration induced additive effects on the normalization of glucose and 4)high levels of physical activity had a positive impact on the continuous glucose fluctuations,while decreased levels of physical activity induced a large fluctuation of glucose due to home confinement of an infectious disease caused by the SARS-CoV-2 virus.Our findings showed that when combined with exercise and metformin treatment for T2D patients,exercise may contribute to improving glycemic control while metformin may elevate lactate levels in the long term.The observed results underline the need to prescribe exercise and monitor lactate levels for reducing possible risks associated with metformin treatment and reinforce the importance of tailoring exercise therapy.