Efficacy and Safety of Adding and Subtracting Decoction of Rehmanniae Combined with Western Medicine in the Treatment of Hypertension:A Systematic Review and Meta-analysis

Objective:Systematically evaluating the efficacy and safety of adding and subtracting decoction of rehmanniae combined with Western medicine in the treatment of hypertension.Methods:PubMed,The Cochrane Library,EMBASE,Web of Science,CNKI,Wanfang Database,VIP database and China Biomedical Literature Service System(CBM)were searched.All randomized controlled studies(RCTs)on adding and subtracting decoction ofrehmanniae combined with Western medicine in the treatment of hypertension were retrieved.The retrieval period is from the database construction to November 2021.Two investigators independently screened the literature,collected baseline data of patients and data on related indicators,and evaluated the risk of bias in the included randomized controlled trials.Meta-analysis was performed by RevMan5.3 software.Results:Five randomized controlled trials including 380 patients were obtained after screening by inclusing and exclusing criteria.Meta-analysis results showed that:In the experimental group,TCM syndrome score(MD=-4.08,95%CI:-5.32 to-2.84,P<0.00001),systolic blood pressure(SBP)(MD=-7.77,95%CI:-12.03 to-3.51,P=0.0003),diastolic blood pressure(DBP)(MD=-6.76,95%CI:-9.59 to-3.93,P<0.00001)were better than the control group,and the differences were statistically significant.Conclusion:The current evidence shows that compared with the simple use of Western medicine,adding and subtracting decoction of rehmanniae combined with Western medicine in the treatment of hypertension has more advantages in improving TCM syndromes and reducing systolic and diastolic blood pressure,and the conclusion is reliable.However,due to the limited number and low quality of included randomized controlled trials,more randomized,double-blind,large-sample clinical studies are needed to confirm the above conclusions.

Efficacy and safety of Guipi Decoction combined with conventional Western medicine in the treatment of insomnia with deficiency of heart and spleen:a meta-analysis

Objective:To systematically evaluate the efficacy and safety of Guipi Decoction combined with Western medicine in the treatment of insomnia with deficiency of heart and spleen.Methods:English databases(PubMed,Web of Science,The Cochrane Library,EMBASE)and Chinese databases(CNKI,Wanfang database,China Biomedical Literature Service System,VIP database)were searched by computer.Randomized controlled trials of Guipi Decoction on insomnia with deficiency of heart and spleen were searched from the database construction to November 2021.After the first and second authors independently screened the literature,extracted the data and evaluated the risk of bias in the included studies,meta-analysis was performed using RevMan5.3 software.Results:A total of 9 RCTS were included after screening,including 914 patients.Meta-analysis results showed that:Total effective rate[RR=1.22,95%CI(1.16,1.30),P<0.00001],total PSQI score[MD=-3.05,95%CI(-3.96,-2.14),P=0.008],number of night awakening times[[MD=-1.18,95%CI(-1.42,-0.94),P<0.00001],adverse reaction rate[RR=0.32,95%CI(0.21,0.51),P<0.00001]were better than the control group,and the differences were statistically significant.Conclusion:The current evidence shows that,compared with pure using conventional western medicine,belongs to the spleen decoction combined western medicine therapy,cases both deficiency type of insomnia in the total effective rate,reducing the total PSQI score(improve sleep quality,sleep efficiency,sleep disorder,daytime function,etc.),reducing frequency of nighttime awakening,security,have more advantages.However,due to the limitation of the quality and quantity of articles included in the study,more randomized,double-blind,large-sample clinical studies are needed to confirm the above conclusions.

Effect of modified Wendan Decoction on enteric glia cells in depression model rats

Background:To explore the effect of modified Wendan Decoction on expression of enteric glial cells in depression model rats.Methods:Eighteen rats were randomly divided into the Blank group,Model group,and modified Wendan Decoction group(Decoction group).Depression was induced by isolation combined with chronic unpredictable mild stress in rats of all groups except for the Blank group.Changes of protein and mRNA expressions of the specific markers of enteric glial cells,glial fibrillary acidic protein,and S100 calcium-binding proteinβsubunit(S100β)in the stomach and colon tissues of rats in each group were detected respectively using immunohistochemistry and reverse transcription-polymerase chain reaction(RT-PCR).Results:Compared with the Blank group,the percentage of positive cells and the mRNA expression of GFAP and S100βwere increased in the Model group,and the difference was statistically significant(P<0.05);compared with the Model group,the percentage of positive cells and the mRNA expression of GFAP and S100βin gastrointestinal tissues of rats were decreased in the Decoction group,and the difference was statistically significant(P<0.05).Conclusion:The depression model rats developed hyperplasia,and enteric glial cells(EGCs)was activated.The mechanism of action of the Wendan Decoction on improving depression and promoting gastrointestinal motility may be achieved by inhibiting the hyperplasia and activation of EGCs in rats with depression.