The in vitro metabolism o. butylphthalide (HBP) by rat liver microsomes was studied in this paper. Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six m...The in vitro metabolism o. butylphthalide (HBP) by rat liver microsomes was studied in this paper. Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six metabolites. 3-Hydroxylation and r-hydroxylation have been proved to be the main metabolism pathways of HBP by rat liver microsomes.展开更多
文摘The in vitro metabolism o. butylphthalide (HBP) by rat liver microsomes was studied in this paper. Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six metabolites. 3-Hydroxylation and r-hydroxylation have been proved to be the main metabolism pathways of HBP by rat liver microsomes.
