What is already known about this topic?Bacterial resistance surveillance is crucial for monitoring and understanding the trends and spread of drug-resistant bacteria.What is added by this report?The number of strains ...What is already known about this topic?Bacterial resistance surveillance is crucial for monitoring and understanding the trends and spread of drug-resistant bacteria.What is added by this report?The number of strains collected in 2022 increased compared to 2021.The top five bacteria,including Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Pseudomonas aeruginosa,and Acinetobacter baumannii,remained largely unchanged.The detection rate of methicillin-resistant strains continued to decrease.Among clinical Enterobacterales isolates,the resistance rate to carbapenems was generally below 13%,except for Klebsiella spp.,which had a resistance range of 20.4%to 21.9%.Most clinical Enterobacterales isolates were highly susceptible to tigecycline,colistin,and polymyxin B,with resistance rates ranging from 0.1%to 12.6%.The detection rate of meropenem-resistant P.aeruginosa and meropenemresistant Acinetobacter baumannii showed a decreasing trend for the fourth consecutive year.What are the implications for public health practice?Multidrug-resistant bacteria remain a significant public health challenge in clinical antimicrobial treatment.To effectively address bacterial resistance,it is essential to enhance both bacterial resistance surveillance and the prudent use of antimicrobial agents.展开更多
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the...This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients （70.41%）. The susceptibility to triple antibiotic ointment （neomycin/bacitracin/polymyxin B） and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.展开更多
基金This research was supported by the National Key Research and Development Program of China(2021YFC2701800 and 2021YFC2701803)the China Antimicrobial Surveillance Network(funding from Pfizer,2023QD020)the Shanghai Antimicrobial Surveillance Network(3030231003).
文摘What is already known about this topic?Bacterial resistance surveillance is crucial for monitoring and understanding the trends and spread of drug-resistant bacteria.What is added by this report?The number of strains collected in 2022 increased compared to 2021.The top five bacteria,including Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Pseudomonas aeruginosa,and Acinetobacter baumannii,remained largely unchanged.The detection rate of methicillin-resistant strains continued to decrease.Among clinical Enterobacterales isolates,the resistance rate to carbapenems was generally below 13%,except for Klebsiella spp.,which had a resistance range of 20.4%to 21.9%.Most clinical Enterobacterales isolates were highly susceptible to tigecycline,colistin,and polymyxin B,with resistance rates ranging from 0.1%to 12.6%.The detection rate of meropenem-resistant P.aeruginosa and meropenemresistant Acinetobacter baumannii showed a decreasing trend for the fourth consecutive year.What are the implications for public health practice?Multidrug-resistant bacteria remain a significant public health challenge in clinical antimicrobial treatment.To effectively address bacterial resistance,it is essential to enhance both bacterial resistance surveillance and the prudent use of antimicrobial agents.
基金The paper was supervised by Dr. Kefei Kang. This work was supported by the Scientific Research Project of Huashan Hospital, Fudan University （No. 2013QD07） and the National Natural Science Foundation of China （No. 81402615）.
文摘This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients （70.41%）. The susceptibility to triple antibiotic ointment （neomycin/bacitracin/polymyxin B） and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.
