Research progress on venous thrombosis development in patients with malignant tumors

The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this population.Over recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related aspects.Furthermore,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer subtypes.We conducted an extensive review encompassing pivotal historical and ongoing studies on CAT.This review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.

Anisotropic s-Wave Gap in the Vicinity of a Quantum Critical Point in Superconducting BaFe_(2)(As_(1-x)P_(x))_(2) Single Crystals:A Study of Point-Contact Spectroscopy

We report on soft c-axis point-contact Andreev reflection(PCAR)spectroscopy combining with resistivity measurements on BaFe_(2)(As_(0.7)P_(0.3))_(2),to elucidate the superconducting gap structure in the vicinity of the quantum critical point.A double peak at the gap edge plus a dip feature at zero-bias has been observed on the PCAR spectra,indicative of the presence of a nodeless gap in BaFe_(2)(As_(0.7)P_(0.3))_(2).Detailed analysis within a sophisticated theoretical model reveals an anisotropic gap with deep gap minima.The PCARs also feature additional structures related to the electron-bosonic coupling mode.Using the extracted superconducting energy gap value,a characteristic bosonic energy Ω_(b) and its temperature dependence are obtained,comparable with the spin-resonance energy observed in neutron scattering experiment.These results indicate a magnetism-driven quantum critical point in the BaFe_(2)(As_(1-x)P_(x))_(2) system.

Carotid-subclavian bypass and endovascular aortic repair of Kommerell’s diverticulum with aberrant left subclavian artery:A case report

BACKGROUND Kommerell’s diverticulum(KD)with aberrant left subclavian artery is a rare congenital deformity and also has very little research literature about it(35%of case study).There are three types of aortic arch diverticulum.Even literature concerning the treatment options are limited.CASE SUMMARY We present a case report of a 50-year-old male with KD in the right aortic arch with aberrant left subclavian artery.We conducted a total endovascular repair procedure,which is innovative and will spread more light in the medical world.Our patient has no past medical history and is a non-smoker and non-alcoholic.Patient presented with shortness of breath,chest pain and dizziness for six months.Blood tests were done and computerized tomography(CT)angiogram of the chest confirmed the diagnosis,illustrating showed a 3.9 cm KD.On Day 1,the CT angiogram showed mild dilatation of the thoracic aorta,adjacent esophagus,trachea was compressed and displaced.Surgery was planned as the treatment modality.Carotid-Subclavian artery bypass and endovascular aortic repair was conducted.We used prolene 5-0 C1 sutures to precisely anastomose a 6-mm Dacron graft to the left subclavian artery.Haemostasis was secured and wounds were closed.Protamine was administered and patient was shifted to intensive care unit.Post-operative,patient responded favorably and was discharged.Regular follow-up is done.CONCLUSION The procedure we performed is novel.This will help the cardio-thoracic surgeons a better insight about the full procedures we conducted,thereby bringing more light and better treatment options in managing KD with aberrant subclavian artery.

Growth and characterization of superconducting Ca_(1-x)Na_(x)Fe_(2)As_(2) single crystals by NaAs-flux method

High-quality superconducting Ca_(1-x)Na_(x)Fe_(2)As_(2)single crystals have been successfully grown by the NaAs-flux method,with sodium doping level x=0.4–0.64.The typical sizes of these crystals are more than 10 mm in ab-plane and~0.1 mm along c-axis in thickness.X-ray diffraction,resistance and magnetization measurements are carried out to characterize the quality of these crystals.While no signature of magnetic phase transitions is detected in the normal state,bulk superconductivity is found for these samples,with a sharp transition at T_(c) ranging from 19.8 K(x=0.4)to 34.8 K(x=0.64).The doping dependences of the c-axis parameter and T_(c) are consistent with previous reports,suggesting a possible connection between the lattice parameters and superconductivity.

Evolution of incommensurate superstructure and electronic structure with Pb substitution in(Bi2-xPbx)Sr2CaCu2O8+δ superconductors

High-quality Bi2-xPbxSr2 CaCu2O8+δ(Bi2212) single crystals have been successfully grown by the traveling solvent floating zone technique with a wide range of Pb substitution(x = 0–0.8).The samples are characterized by transmission electron microscope(TEM) and measured by high resolution laser-based angle-resolved photoemission spectroscopy(ARPES) with different photon energies.A systematic evolution of the electronic structure and superstructure with Pb substitution has been revealed for the first time.The superstructure shows a significant change with Pb substitution and the incommensurate modulation vector(Q) decreases with increasing Pb substitution.In the meantime, the superstructure intensity from ARPES measurements also decreases dramatically with increasing Pb concentration.The superstructure in Bi2212 can be effectively suppressed by Pb substitution and it nearly disappears with a Pb substitution of x = 0.8.We also find that the superstructure bands in ARPES measurements depend sensitively on the photon energy of lasers used;they can become even stronger than the main band when using a laser photon energy of 10.897 eV.These results provide important information on the origin of the incommensurate superstructure and its control and suppression in bismuth-based high temperature superconductors.

Neutron Powder Diffraction Study on the Non-Superconducting Phases of ThFeAsN1-xOx（x=0.15,0.6）Iron Pnictide

We use neutron powder diffraction to study the non-superconducting phases of ThFeAsN1-xOx with x = 0.15,0.6.In our previous results of the superconducting phase ThFeAsN with Tc = 30 K,no magnetic transition is observed by cooling down to 6 K,and possible oxygen occupancy at the nitrogen site is shown in the refinement[Europhys.Lett.117(2017)57005].Here in the oxygen doped system ThFeAsN1-xOx,two superconducting regions(0≤x≤0.1 and 0.25≤x≤0.55)are identified by transport experiments[J.Phys.:Condens.Matter30(2018)255602].However,within the resolution of our neutron powder diffraction experiment,neither the intermediate doping x= 0.15 nor the heavily overdoped compound x = 0.6 shows any magnetic order from 300 K to 4 K.Therefore,while it shares the common phenomenon of two superconducting domes as most 1111-type iron-based superconductors,the magneticall.y ordered parent compound may not exist in this nitride family.

19F NMR Study of the Bilayer Iron-Based Superconductor KCa2Fe4As4F2

We report a^19F nuclear magnetic resonance(NMR)study on single-crystal KCa2 Fe4As4F2(Tc^33.3 K).The 19F NMR spectral shape of KCa2Fe4As4F2 is weakly dependent on temperature and the Knight shift is small,which implies weak coupling between the Ca F layer and the Fe As layer.The temperature dependence of 1/^19T1 shows a hump below Tc,however the 1/^75T1 decreases just below Tc,which implies that there are strong in-plane magnetic fluctuations in the Ca F layers than in the Fe As layers.This may be caused by the motion of vortices.The absence of the coherence peak suggests unconventional superconductivity in KCa2Fe4As4F2.

Dispersion of neutron spin resonance mode in Ba_(0.67)K_(0.33)Fe_(2)As_(2)

We report an inelastic neutron scattering investigation on the spin resonance mode in the optimally hole-doped ironbased superconductor Ba_(0.67)K_(0.33)Fe_(2)As_(2)with T_c=38.2 K.Although the resonance is nearly two-dimensional with peak energy ER≈14 meV,it splits into two incommensurate peaks along the longitudinal direction([H,0,0])and shows an upward dispersion persisting to 26 meV.Such dispersion breaks through the limit of total superconducting gaps△_(tot)=|△k|+|△k+Q|(about 11-17 meV)on nested Fermi surfaces measured by high resolution angle resolved photoemission spectroscopy(ARPES).These results cannot be fully understood by the magnetic exciton scenario under s^(±)-pairing symmetry of superconductivity,and suggest that the spin resonance may not be restricted by the superconducting gaps in the multi-band systems.

Incommensurate Magnetic Order in Sm_(3)BWO_(9)with Distorted Kagome Lattice

We investigate the magnetic ground state of Sm_(3)BWO_(9)with a distorted kagome lattice.A magnetic phase transition is identified at T_(N)=0.75 K from the temperature dependence of specific heat.From 11B nuclear magnetic resonance measurements,an incommensurate magnetic order is shown by the double-horn type spectra under a c-axis magnetic field,and absence of line splitting is observed for field oriented within the ab-plane,indicating the incommensurate modulation of the internal field strictly along𝑐c-axis.From the spin dynamics,the critical slowing-down behavior is observed in the temperature dependence of 1/T_(1)with𝜇_(μ0)H⊥c-axis,which is completely absent in the case with𝜇_(μ0)H||c-axis.Based on the local symmetry of 11B sites,we analyze the hyperfine coupling tensors and propose two constraints on the possible magnetic structure.The single ion anisotropy should play an important role in determination of contrasting ground states of Sm_(3)BWO_(9) and Pr_(3)BWO_(9).

Ultrasound guided acupotomy in treating rhomboid muscle and serratus posterior superior muscle injury:a case report

Objective:The study intended to show us the effect and safety associated with ultrasound-guidance during acupotomy treatment by a case report.Methods:The research presented a case study using ultrasound-guided acupotomy in back pain.The study took place in the Department of Acupuncture and Moxibustion,China-Japan Friendship Hospital.A 56-year-old woman with paroxysmal right upper back pain for more than 10 years,who was diagnosed as the rhomboid muscle and serratus posterior superior muscle injury.Results:After two acupotomy treatments,the Visual Analogue Score(VAS)of the patient declined from7 to 2.One month later,the pain disappeared and the patient was satisfied with it.Conclusion:Ultrasound guidance can be used to observe the anatomical structures clearly to improve the safety of acupotomy treatment.

Exploring the Pathways and Targets of Shexiang Baoxin Pill for Coronary Heart Disease through a Network Pharmacology Approach

Objective: To investigate the network pharmacology of Shexiang Baoxin pill(SBP) and systematically analyze the mechanisms of SBP.Methods: In this study, we excavated all the targets of 26 constituents of SBP which were identified in rat plasma though literature mining and target calculation(reverse docking and similarity search) and analyzed the multiple pharmacology actions of SBP comprehensively through a network pharmacology approach.Results: In the end, a total of 330 Homo sapiens targets were identified for 26 blood constituents of SBP.Moreover, the pathway enrichment analysis found that these targets mapped into 171 KEGG pathways and 31 of which were more enriched.Among these identified pathways, 3 pathways were selected for analyzing the mechanisms of SBP for treating coronary heart disease.Conclusion: This study systematically illustrated the mechanisms of the SBP by analyzing the corresponding "drug-target-pathway-disease" interaction network.