To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A gene...To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A genetic study recently revealed that ASGR1 haploinsufficiency resulted from loss-of-function(LOF)variants was strongly associated with the pronounced reductions in serum total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels,[2,3]suggesting that ASGR1 may play a key role in cholesterol metabolism.However,the function of ASGR1 remains largely unclear.This study was focused on the association of ASGR1 gene expression in monocytes and plasma cholesterol level.展开更多
基金This work was supported by grants from the Natural Science Foundation of Hunan Province in China(Nos.2017JJ3250 and 2019JJ40230)the Science and Technology Plan Project of the Health commission of Hunan Province in China(Nos.B2019034 and B2019035).
文摘To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A genetic study recently revealed that ASGR1 haploinsufficiency resulted from loss-of-function(LOF)variants was strongly associated with the pronounced reductions in serum total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels,[2,3]suggesting that ASGR1 may play a key role in cholesterol metabolism.However,the function of ASGR1 remains largely unclear.This study was focused on the association of ASGR1 gene expression in monocytes and plasma cholesterol level.
