Analysis of microblog public opinion characteristics on traditional Chinese medicine against COVID-19 based on deep learning

The opinion research on traditional Chinese medicine during the coronavirus disease 2019(COVID-19)pandemic on microblog,a social network,took into account the national people’s fight against COVID-19—the research background—the strength of traditional Chinese medicine during the pandemic—the research topic—and the public opinion—the research object.The timeline was divided into three stages according to the overall heat change.In order to explore and compare people’s emotion and topics of concern on traditional Chinese medicine during the different stages of the pandemic,deep learning analysis methods such as emotional analysis and Latent Dirichlet Allocation analysis were used.This study found that the public’s positive“emotional composition”on traditional Chinese medicine significantly improved within the timeline,while the public’s autonomy was enhanced and the overall public opinion started to show an increased trend.

On the present and future of medical humanistic care in the era of artificial intelligence

With the arrival of the fourth industrial revolution,the combination of artificial intelligence and medical treatment has become an inevitable trend.As a people-centered discipline,the importance of humanistic care is self-evident.Based on the development status of humanistic care,this paper discusses that when artificial intelligence is applied to medicine,it will help patients improve the treatment process,protect their right to know and expression,help medical personnel deal with repetitive work,improve work efficiency,provide doctors with psychological medical time and enhance doctor-patient trust.At the same time,it will inevitably lead to the lack of emotion in the way of diagnosis and treatment,the threat to the authority of doctors,and the disclosure of patients'personal information.Therefore,in the era of artificial intelligence,doctors should return to the service foundation of humanistic care,"master"the"art of medicine"of artificial intelligence technology,and improve the practical road of laws and regulations.

The mechanism of hepatotoxicity of Nux Vomica:a network-pharmacology-based study

Objective:To explore the potential mechanism of hepatotoxicity induced by Nux Vomica through network toxicology.Methods:The active components and targets of Nux Vomica were identified and screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform Database(TCMSP),literature research,PubChem Database,Swiss Target Prediction database,etc.Genecards,pharmGKB and OMIM databases were used to collect hepatotoxicity related targets,then,cross them with active component targets to obtain potential targets of hepatotoxicity caused by Nux Vomica.A"Nux Vomica-Potential active components-Potential targets-Hepatotoxicity"network was constructed with Cytoscape 3.8.0 software.The String 11.0 database was used to construct the protein-protein interaction(PPI)network of the targets and to screen out the core targets.In addition,Gene Ontology(GO)function enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were conducted by R software,and then the obtained pathways directly related to hepatotoxicity were integrated.Results:In this study,37 active components were screened via TCMSP and literature research,468 targets for the active components of Nux Vomica were obtained.There were 533 hepatotoxicity-related targets,73 potential targets for hepatotoxicity caused by Nux Vomica,and 26 potential active components,among which Ferulic acid,Novacine,Icajine,Simiarenol were the key active components for hepatotoxicity caused by Nux Vomica,and JUN,RELA,and STAT3 were the core target proteins of hepatotoxicity caused by Nux Vomica.There were 1859 GO entries(P-value<0.05),including 1709 entries of Biological Process(BP),39 entries of Cellular Component(CC),and 111 entries of Molecular Function(MF).KEGG enrichment analysis revealed 145 pathways(value<0.05),of which PI3K/AKT signaling pathway,HIF-1 signaling pathway,EGFR tyrosine kinase inhibitor resistance were strongly correlated with the hepatotoxicity caused by Nux Vomica.Conclusion:Through network toxicology analysis,it was found that lots of potential components in Nux Vomica may be involved in the activation of the excessive inflammatory response,oxidative stress,and the LPS response through multiple targets and multiple pathways,resulting in the generation of hepatotoxicity.

Meta-analysis of the comparison between reduning injection and ribavirin injection for acute upper respiratory tract infection in children

Objective:To systematically evaluate the effectiveness and safety of reduning injection in acute upper respiratory tract infection of children.Methods:Use computer to search PubMed,the Cochrane Library,EMBASE,Web of Science,China National Knowledge Infrastructure(CNKI),Wanfang Database,Weipu database(VIP)and China Biomedical studies Service System(CBM)for randomized controlled trials(RCT)of acute upper respiratory tract infection in children,and the retrieval time is from their establishment to May,2022.After two researchers independently screened the studies,extracted data and evaluated the risk bias of studies,RevMan5.3 software was used to perform meta-analysis.Results:10 studies in total were included,involving 1466 patients.Results of the meta-analysis:total effective rate[RR=1.12,95%CI(1.07,1.16),P<0.00001],cure time[MD=-1.51,95%CI(-1.71,-1.32),P<0.00001],antipyretic time[MD=-1.32,95%CI(-1.72,-0.92),P<0.00001],disappearing time of nasal obstruction and nose running[MD=-1.04,95%CI(-1.45,-0.62),P<0.00001],disappearing time of cough[MD=-1.35,95%CI(-1.58,-1.13),P<0.00001],disappearing time of throat congestion[MD=-1.36,95%CI(-1.68,-1.03),P<0.00001],disappearing time of sore throat[MD=-1.55,95%CI(-1.74,-1.35),P<0.00001],the incidence of adverse reactions[RR=0.34,95%CI(0.20,0.57),P<0.0001].The differences between two groups in total effective rate,cure time,antipyretic time,disappearing time of nasal obstruction and nose running,disappearing time of cough,disappearing time of throat congestion,disappearing time of sore throat and the incidence of adverse reactions are all statistically significant(P<0.05).The sensitivity analysis demonstrates that three outcomes(total effective rate,cure time and disappearing time of sore throat)have unstable results,while others having stable results.Conclusion:Reduning injection is more effective than ribavirin injection in clinical,and it is better than ribavirin injection at relieving fever,nasal obstruction and nose running,cough and throat congestion.In addition,it’s safer in clinical than ribavirin injection.

To explore acupuncture therapy for post-stroke gastrointestinal dysfunction based on gut microbiota

The occurrence of post-stroke gastrointestinal disorder(PSGD)is closely related to gut microbiota.Acupuncture has a positive effect on PSGD.However,it is not completely clear how acupuncture can mediate the regulation of gut microbiota in the treatment of PSGD.In this paper,the relationship between PSGD risk factors and gut microbiota,the relationship between gut microbiota and PSGD,the regulation of gut microbiota and metabolites by acupuncture,and the application research progress of acupuncture in regulating PSGD were reviewed to explore the mechanism of gut microbiota in the treatment of PSGD.We found that acupuncture can improve intestinal mucosal permeability,increase the number of beneficial bacteria such as Bifidobacterium and Lactobacillus,and increase serum 5-hydroxytryptamine(5-HT)and short chain fatty acids(SCFAs)to relieve gastrointestinal symptoms and improve PSGD.