Treatment of superficial corneal opacities with corneal stromal lenticule obtained through SMILE surgery

AIM:To evaluate the clinical efficacy and feasibility of superficial corneal opacities treated by excimer laser phototherapeutic keratectomy(PTK)combined with small incision lenticule extraction(SMILE)-derived corneal stromal lenticule transplantation.METHODS:A retrospective interventional case series of nine patients aged 12-59y with superficial corneal opacity caused by different pathologies who underwent standardized PTK combined with SMILE-derived corneal stromal lenticule transplantation was examined.Lenticule patches were fixed with fibrin glue.All patients underwent pre-and post-operative clinical assessments at different times for up to 12mo.Slit lamp microscopy,corneal density,uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),and anterior segment optical coherence tomography(AS-OCT)were examined.RESULTS:The patients’mean age was 36.00±5.80(12-59)y.Seven eyes(77.8%)gained UDVA and CDVA at the last measurement compared to their preoperative levels.The densities of the total cornea,the total anterior corneal layer,and the anterior corneal layers of 0-2 and 2-6 mm decreased significantly by 12.4%,27.5%,46.7%,and 32.8%,respectively.After human allogeneic transplantation,the implanted lenticules of all eyes were clearly visible by AS-OCT and remained transparent without displacement or graft rejection.The thickness of the central cornea and corneal lenticule transplants were stable throughout the entire postoperative period.One case experienced the postoperative complication of delayed corneal epithelial healing.CONCLUSION:PTK combined with SMILE-derived corneal lenticule transplantation improves long-term visual acuity.Therefore,it is a new,safe,and effective method for treating superficial corneal opacity.

屈光参差儿童单眼配戴角膜塑形镜后调节功能的变化

目的:观察屈光参差儿童单眼配戴角膜塑形镜后双眼调节功能的变化,探讨调节在角膜塑形镜控制近视进展中的机制。方法:前瞻性自身对照研究,对2016-09/2018-09在我院门诊就诊的屈光参差儿童单眼配戴角膜塑形镜的青少年22例44眼,将配戴角膜塑形镜的眼作为戴镜组,未作处理的另一眼作为未戴镜组。戴镜眼组22眼,等效球镜度-2.75±1.16D;未戴镜眼组22眼,等效球镜度-0.10±0.32D。观察戴镜前和戴镜12mo后双眼屈光度差值、单眼调节幅度、调节灵敏度和调节反应的变化情况。结果:戴镜组戴镜前的调节幅度和调节灵敏度低于未戴镜组(P<0.01),调节滞后高于未戴镜组(P<0.05)。戴镜组配戴12mo后的单眼调节幅度15.63±1.66D高于戴镜前11.25±3.15D(t=3.63,P<0.01),与未戴镜组无差异(t=0.75,P=0.46)。戴镜组配戴12mo后的单眼调节灵敏度14.63±1.58cyc/min高于戴镜前9.25±3.38cyc/min(t=2.83,P=0.01),与未戴镜组无差异(t=0.38,P=0.71)。戴镜组配戴12mo后的调节滞后0.62±0.29D较戴镜前1.35±0.26D减少(t=2.57,P=0.02),与未戴镜组无差异(t=0.61,P=0.55)。戴镜12mo后,未戴镜组的平均屈光度为-0.75±0.35D,戴镜组屈光度增长了-0.15±0.22D(t=2.90,P<0.01),未戴镜组屈光度增长了-0.65±0.39D(t=4.24,P<0.01),两组间屈光度的变化差值有差异(t=5.30,P<0.01)。未戴镜组12mo前后调节功能的变化无差异(P>0.05)。结论:屈光参差儿童单眼配戴角膜塑形镜后戴镜眼的调节功能较戴镜前明显改善,且与对侧眼一致,戴镜眼的屈光状态更稳定,未戴镜眼逐渐呈现轻度近视屈光状态,但调节功能未出现明显变化。