AIM:To systematically evaluate the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer.METHODS:A comprehensive electronic search was conducted for articles published up until ...AIM:To systematically evaluate the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer.METHODS:A comprehensive electronic search was conducted for articles published up until January 27,2014 in Medline(PubMed),Excerpta Medica Database(Embase),the Cochrane Library and Google Scholar.Only case-control studies published in English that evaluated the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer were included.Furthermore,only studies with sufficient data allowing for calculation of odds ratio(OR) and corresponding 95% confidence interval(CI) were included.These values were used in the quantitative synthesis to assess the strength of the association between the miR-146 a rs2910164 polymorphism and risk of gastric cancer.RESULTS:The database search identified 1002 eligible studies,of which seven(comprising 4112 cases and 5811 controls) were included for the meta-analysis.The results indicate that miR-146 a rs2910164 polymorphism is more likely to be associated with gastric cancer risk.In the overall analysis,a significantly increased cancer risk was found in the heterozygote(GG vs GC) comparison(OR = 1.14,95%CI:1.03-1.27; P = 0.01 for pooled OR).In the ethnicity subgroup analysis,a similar result was found among Caucasians(OR = 1.36,95%CI:1.01-1.85; P = 0.04 for pooled OR).In the stratified analysis by quality of studies,a significantly increased cancer risk was found in the heterozygote comparison among high quality studies(OR = 1.12,95%CI:1.01-1.26; P = 0.04 for pooled OR).When stratified on the basis of sample size,a significantly increased cancer risk was found among small sample size subgroups for the allelic(G vs C:OR = 1.16,95%CI:1.03-1.30; P = 0.01),homozygote(GG vs CC:OR = 1.33,95%CI:1.03-1.73; P = 0.03) and recessive model(GG vs GC + CC:OR = 0.05,95%CI:0.00-0.10; P = 0.03) comparisons.CONCLUSION:The miR-146 a rs2910164 polymorphism is associated with increased gastric cancer risk,particularly evident in high quality studies with small sample sized Caucasian populations.展开更多
Gastric intramural hematoma is a rare injury of the stomach,and is most often seen in patients with underlying disease.Such injury following endoscopic therapy is even rarer,and there are no universally accepted guide...Gastric intramural hematoma is a rare injury of the stomach,and is most often seen in patients with underlying disease.Such injury following endoscopic therapy is even rarer,and there are no universally accepted guidelines for its treatment.In this case report,we describe a gastric intramural hematoma which occurred within 6 h of endoscopic mucosal resection(EMR).Past medical history of this patient was negative,and laboratory examinations revealed normal coagulation profiles and platelet count.Following EMR,the patient experienced severe epigastric pain and vomited 150 mL of gastric contents which were bright red in color.Subsequent emergency endoscopy showed a 4 cm × 5 cm diverticulum-like defect in the anterior gastric antrum wall and a 4 cm × 8 cm intramural hematoma adjacent to the endoscopic submucosal dissection lesion.Following unsatisfactory temporary conservative management,the patient was treated surgically and made a complete recovery.Retrospectively,one possible reason for the patient's condition is that the arterioles in the submucosa or muscularis may have been damaged during deep and massive submucosal injection.Thus,endoscopists should be aware of this potential complication and improve the level of surgery,especially the skills required for submucosal injection.展开更多
Objective:The objective of this study is to investigate the current status of comfort with touch among nursing staff in the rehabilitation department and analyze its influencing factors.Materials and Methods:The conve...Objective:The objective of this study is to investigate the current status of comfort with touch among nursing staff in the rehabilitation department and analyze its influencing factors.Materials and Methods:The convenience sampling method was used to select 131 nursing staff in the rehabilitation department of 3A-level hospitals in Yunnan Province,China,from March to June 2020 to conduct a questionnaire survey.Results:The nurses’comfort with touch score of 131 clinical nurses in the rehabilitation department was 58.82±4.85.Multivariate regression analysis showed that compassion fatigue(t=‒2.968,P<0.01)and occupational social support(t=2.767,P<0.01)were the influencing factors of the physical comfort of nursing staff;average monthly income(t=‒2.160,P<0.05),occupational cognitive evaluation(t=4.924,P<0.01),and secondary traumatic stress(t=2.833,P<0.01)were the influencing factors of task-oriented contact among nursing staff;marital status(t=2.656,P<0.01)and occupational social support(t=2.078,P<0.05)were the influencing factors for private nursing comfort of nurses.Conclusion:The comfort with touch among nurses in the rehabilitation department is at a medium level.Nursing managers should pay attention to their comfort with touch.In order to promote the development of medical service,hospitals should constantly improve the security and social support of nursing practitioners from the aspects of system,management,and salary performance.展开更多
To the Editor：Early primary gastrointestinal non-Hodgkin＆#39;s lymphoma represents a diagnostic challenge and may be easily misdiagnosed as Crohn＆#39;s disease or intestinal tuberculosis.[1] Here,we describe a 58-y...To the Editor：Early primary gastrointestinal non-Hodgkin＆#39;s lymphoma represents a diagnostic challenge and may be easily misdiagnosed as Crohn＆#39;s disease or intestinal tuberculosis.[1] Here,we describe a 58-year-old man who was admitted due to recurrent colic in the middle and upper abdomen with intermittent vomiting for l 0 months.The colic was paroxysmal lasting from a few minutes to several hours without obvious triggers.His medical history was otherwise unremarkable.In November 2013,gastrointestinal endoscopy revealed gastroenteritis,and abdominal computed tomography （CT） showed jejunal wall edema and thickening.His symptoms did not improve after 1-month treatment for suspected gastroenteritis.展开更多
基金Supported by The Natural Science Foundation of Hubei Province,No.2013CFA076
文摘AIM:To systematically evaluate the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer.METHODS:A comprehensive electronic search was conducted for articles published up until January 27,2014 in Medline(PubMed),Excerpta Medica Database(Embase),the Cochrane Library and Google Scholar.Only case-control studies published in English that evaluated the association between the miR-146 a rs2910164 polymorphism and susceptibility to gastric cancer were included.Furthermore,only studies with sufficient data allowing for calculation of odds ratio(OR) and corresponding 95% confidence interval(CI) were included.These values were used in the quantitative synthesis to assess the strength of the association between the miR-146 a rs2910164 polymorphism and risk of gastric cancer.RESULTS:The database search identified 1002 eligible studies,of which seven(comprising 4112 cases and 5811 controls) were included for the meta-analysis.The results indicate that miR-146 a rs2910164 polymorphism is more likely to be associated with gastric cancer risk.In the overall analysis,a significantly increased cancer risk was found in the heterozygote(GG vs GC) comparison(OR = 1.14,95%CI:1.03-1.27; P = 0.01 for pooled OR).In the ethnicity subgroup analysis,a similar result was found among Caucasians(OR = 1.36,95%CI:1.01-1.85; P = 0.04 for pooled OR).In the stratified analysis by quality of studies,a significantly increased cancer risk was found in the heterozygote comparison among high quality studies(OR = 1.12,95%CI:1.01-1.26; P = 0.04 for pooled OR).When stratified on the basis of sample size,a significantly increased cancer risk was found among small sample size subgroups for the allelic(G vs C:OR = 1.16,95%CI:1.03-1.30; P = 0.01),homozygote(GG vs CC:OR = 1.33,95%CI:1.03-1.73; P = 0.03) and recessive model(GG vs GC + CC:OR = 0.05,95%CI:0.00-0.10; P = 0.03) comparisons.CONCLUSION:The miR-146 a rs2910164 polymorphism is associated with increased gastric cancer risk,particularly evident in high quality studies with small sample sized Caucasian populations.
文摘Gastric intramural hematoma is a rare injury of the stomach,and is most often seen in patients with underlying disease.Such injury following endoscopic therapy is even rarer,and there are no universally accepted guidelines for its treatment.In this case report,we describe a gastric intramural hematoma which occurred within 6 h of endoscopic mucosal resection(EMR).Past medical history of this patient was negative,and laboratory examinations revealed normal coagulation profiles and platelet count.Following EMR,the patient experienced severe epigastric pain and vomited 150 mL of gastric contents which were bright red in color.Subsequent emergency endoscopy showed a 4 cm × 5 cm diverticulum-like defect in the anterior gastric antrum wall and a 4 cm × 8 cm intramural hematoma adjacent to the endoscopic submucosal dissection lesion.Following unsatisfactory temporary conservative management,the patient was treated surgically and made a complete recovery.Retrospectively,one possible reason for the patient's condition is that the arterioles in the submucosa or muscularis may have been damaged during deep and massive submucosal injection.Thus,endoscopists should be aware of this potential complication and improve the level of surgery,especially the skills required for submucosal injection.
文摘Objective:The objective of this study is to investigate the current status of comfort with touch among nursing staff in the rehabilitation department and analyze its influencing factors.Materials and Methods:The convenience sampling method was used to select 131 nursing staff in the rehabilitation department of 3A-level hospitals in Yunnan Province,China,from March to June 2020 to conduct a questionnaire survey.Results:The nurses’comfort with touch score of 131 clinical nurses in the rehabilitation department was 58.82±4.85.Multivariate regression analysis showed that compassion fatigue(t=‒2.968,P<0.01)and occupational social support(t=2.767,P<0.01)were the influencing factors of the physical comfort of nursing staff;average monthly income(t=‒2.160,P<0.05),occupational cognitive evaluation(t=4.924,P<0.01),and secondary traumatic stress(t=2.833,P<0.01)were the influencing factors of task-oriented contact among nursing staff;marital status(t=2.656,P<0.01)and occupational social support(t=2.078,P<0.05)were the influencing factors for private nursing comfort of nurses.Conclusion:The comfort with touch among nurses in the rehabilitation department is at a medium level.Nursing managers should pay attention to their comfort with touch.In order to promote the development of medical service,hospitals should constantly improve the security and social support of nursing practitioners from the aspects of system,management,and salary performance.
文摘To the Editor：Early primary gastrointestinal non-Hodgkin＆#39;s lymphoma represents a diagnostic challenge and may be easily misdiagnosed as Crohn＆#39;s disease or intestinal tuberculosis.[1] Here,we describe a 58-year-old man who was admitted due to recurrent colic in the middle and upper abdomen with intermittent vomiting for l 0 months.The colic was paroxysmal lasting from a few minutes to several hours without obvious triggers.His medical history was otherwise unremarkable.In November 2013,gastrointestinal endoscopy revealed gastroenteritis,and abdominal computed tomography （CT） showed jejunal wall edema and thickening.His symptoms did not improve after 1-month treatment for suspected gastroenteritis.
