期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Quorum sensing inhibition of hordenine analogs on Pseudomonas aeruginosa and Serratia marcescens
1
作者 Yue Liu Jun-Jian Li +2 位作者 Hong-Yuan Li shi-ming deng Ai-Qun Jia 《Synthetic and Systems Biotechnology》 SCIE 2021年第4期360-368,共9页
Quorum sensing(QS)plays an essential role in virulence factor production,biofilm formation,and antimicrobial resistance.As a potent QS inhibitor,hordenine can inhibit both QS and biofilm formation in Pseudomonas aerug... Quorum sensing(QS)plays an essential role in virulence factor production,biofilm formation,and antimicrobial resistance.As a potent QS inhibitor,hordenine can inhibit both QS and biofilm formation in Pseudomonas aeruginosa and Serratia marcescens.In this work,we tested the QS inhibitory potential of 27 hordenine analogs against QS and biofilm formation in P.aeruginosa and S.marcescens.Among the tested analogs,seven(12,28,27,26,2,23,and 7)exhibited strong QS inhibitory activity against P.aeruginosa,five of which(12,28,27,26,and 2)showed better inhibitory activity than hordenine.In addition,seven analogs(28,12,23,7,26,2,and 27)exhibited better biofilm inhibition against P.aeruginosa than hordenine.Four analogs(7,28,2,and 12)showed QS inhibitory activity against S.marcescens,two of which(7 and 28)demonstrated better inhibitory activity than hordenine.Furthermore,analog 7 showed similar biofilm inhibition against S.marcescens as hordenine.Structure-activity relationship(SAR)analysis indicated that the inhibitory activities of the analogs were related to four factors,i.e.,carbon chain length,presence or absence of anα,β-C=C bond,amino group with/without lipophilic group,such as methyl group,and hydroxyl group in benzene ring. 展开更多
关键词 Hordenine analogs Pseudomonas aeruginosa Serratia marcescens Quorum sensing inhibition QSAR BIOFILM
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部