The corrosion behaviors of 304SS, 316LSS, and Q235A in LiCl-KCl melts were investigated at 450℃ by Tafel curves and elec- trochemical impedance spectroscopy (EIS). 316LSS shows the best corrosion resistance behavio...The corrosion behaviors of 304SS, 316LSS, and Q235A in LiCl-KCl melts were investigated at 450℃ by Tafel curves and elec- trochemical impedance spectroscopy (EIS). 316LSS shows the best corrosion resistance behaviors among the three materials, including the most positive corrosion potential and the smallest corrosion current from the Tafel curves and the largest electron transfer resistance from the Nyquist plots. The results are in good agreement with the weight losses in the static corrosion experiments for 45 h. This may be attributed to the better corrosion resistance of Mo and Ni existing as alloy elements in 316LSS, which exhibit the lower corrosion current densities and more positive corrosion potentials than 316LSS in the same melts.展开更多
BACKGROUND Polyacrylamide hydrogel(PAAG)injections were once common in breast augmentation and have been prohibited for augmentation mammaplasty in China since a large number of patients who underwent breast augmentat...BACKGROUND Polyacrylamide hydrogel(PAAG)injections were once common in breast augmentation and have been prohibited for augmentation mammaplasty in China since a large number of patients who underwent breast augmentation with PAAG injections have continued to seek medical advice as a result of related complications.Among all these complications,distant migration is relatively rare.CASE SUMMARY A 49-year-old female presented at the hospital with a one-year history of a vulvar lump.The sonography of the lump showed several subcutaneous fluid-filled regions from the left vulva to the pubic symphysis,which suggested possible fat liquefaction.An enhanced magnetic resonance imaging(MRI)revealed a cystic area,which was considered a benign lesion.Intraoperative observations showed that the mass did not have an obvious capsule,the subcutaneous tissue presented as a cavity,and some yellow material came out of this cavity.A culture of the drainage did not show bacterial contamination.Histopathology revealed a foreign body granuloma.After resection and closed drainage,lumps were successively observed in the left lower abdomen and the bilateral hypochondriac region with infections.Sonography found that the hypoechoic areas in the bilateral hypochondriac region seemed continuous with deep in the breasts.The patient reported that she had undergone surgery with PAAG injections 20 years ago after she was repeatedly asked about her past history.Finally,a diagnosis of distant migration of PAAG was made.CONCLUSION PAAG gel can migrate after long periods of time.A diagnosis should not be limited to the area where the symptom develops.展开更多
We performed ultra-low temperature thermal conductivity measurements on the single crystal of a new gold-based quasi-two-dimensional superconductor Au Te2Se(4/3), which has a superconducting transition temperature T...We performed ultra-low temperature thermal conductivity measurements on the single crystal of a new gold-based quasi-two-dimensional superconductor Au Te2Se(4/3), which has a superconducting transition temperature Tc = 2.70 K. A negligible residual linear term κ0/T in zero magnetic field is observed, which suggests fully gapped superconducting state.Furthermore, the field dependence of κ0/T is similar to that of the multi-band s-wave superconductor Ba Fe1.9 Ni0.1 As2 at low field. These results reveal multiple nodeless superconducting gaps in this interesting quasi-two-dimensional superconductor with Berezinsky–Kosterlitz–Thouless topological transition.展开更多
Urokinase-targeted recombinant bacterial protein toxins are a sort of rationally designed and engineered anticancer recombinant fusion proteins representing a novel class of agents for cancer therapy.Bacterial protein...Urokinase-targeted recombinant bacterial protein toxins are a sort of rationally designed and engineered anticancer recombinant fusion proteins representing a novel class of agents for cancer therapy.Bacterial protein toxins have long been known as the primary virulence factor(s)for a variety of pathogenic bacteria and are the most powerful human poisons.On the other hand,it has been well documented that urokinase-type plasminogen activator(uPA)and urokinase plasminogen activator receptor(uPAR),making up the uPA system,are overexpressed in a variety of human tumors and tumor cell lines.The expression of uPA system is highly correlated with tumor invasion and metastasis.To exploit these characteristics in the design of tumor cell-selective cytotoxins,two prominent bacterial protein toxins,i.e.,the diphtheria toxin and anthrax toxin are deliberately engineered through placing a sequence targeted specifically by the uPA system to form anticancer recombinant fusion proteins.These uPA system-targeted bacterial protein toxins are activated selectively on the surface of uPA systemexpressing tumor cells,thereby killing these cells.This article provides a review on the latest progress in the exploitation of these recombinant fusion proteins as potent tumoricidal agents.It is perceptible that the strategies for cancer therapy are being innovated by this novel therapeutic approach.展开更多
基金financially supported by the National High-Tech Research and Development Program of China(No.2009AA06Z102)the National Natural Science Foundation of China(Nos.50934001 and 51054004)
文摘The corrosion behaviors of 304SS, 316LSS, and Q235A in LiCl-KCl melts were investigated at 450℃ by Tafel curves and elec- trochemical impedance spectroscopy (EIS). 316LSS shows the best corrosion resistance behaviors among the three materials, including the most positive corrosion potential and the smallest corrosion current from the Tafel curves and the largest electron transfer resistance from the Nyquist plots. The results are in good agreement with the weight losses in the static corrosion experiments for 45 h. This may be attributed to the better corrosion resistance of Mo and Ni existing as alloy elements in 316LSS, which exhibit the lower corrosion current densities and more positive corrosion potentials than 316LSS in the same melts.
基金Supported by Zhejiang Provincial Medical and Health Platform Project,No.2018275889
文摘BACKGROUND Polyacrylamide hydrogel(PAAG)injections were once common in breast augmentation and have been prohibited for augmentation mammaplasty in China since a large number of patients who underwent breast augmentation with PAAG injections have continued to seek medical advice as a result of related complications.Among all these complications,distant migration is relatively rare.CASE SUMMARY A 49-year-old female presented at the hospital with a one-year history of a vulvar lump.The sonography of the lump showed several subcutaneous fluid-filled regions from the left vulva to the pubic symphysis,which suggested possible fat liquefaction.An enhanced magnetic resonance imaging(MRI)revealed a cystic area,which was considered a benign lesion.Intraoperative observations showed that the mass did not have an obvious capsule,the subcutaneous tissue presented as a cavity,and some yellow material came out of this cavity.A culture of the drainage did not show bacterial contamination.Histopathology revealed a foreign body granuloma.After resection and closed drainage,lumps were successively observed in the left lower abdomen and the bilateral hypochondriac region with infections.Sonography found that the hypoechoic areas in the bilateral hypochondriac region seemed continuous with deep in the breasts.The patient reported that she had undergone surgery with PAAG injections 20 years ago after she was repeatedly asked about her past history.Finally,a diagnosis of distant migration of PAAG was made.CONCLUSION PAAG gel can migrate after long periods of time.A diagnosis should not be limited to the area where the symptom develops.
基金supported by the Key Basic Research Program of China(Grant Nos.2015CB921401 and 2016YFA0300503)the National Natural Science Foundation of China(Grant Nos.11422429 and 11421404)+2 种基金China Postdoctoral Science Foundation(Grant No.2016T90332)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning,and STCSM of China(Grant No.15XD1500200)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB04040200)
文摘We performed ultra-low temperature thermal conductivity measurements on the single crystal of a new gold-based quasi-two-dimensional superconductor Au Te2Se(4/3), which has a superconducting transition temperature Tc = 2.70 K. A negligible residual linear term κ0/T in zero magnetic field is observed, which suggests fully gapped superconducting state.Furthermore, the field dependence of κ0/T is similar to that of the multi-band s-wave superconductor Ba Fe1.9 Ni0.1 As2 at low field. These results reveal multiple nodeless superconducting gaps in this interesting quasi-two-dimensional superconductor with Berezinsky–Kosterlitz–Thouless topological transition.
文摘Urokinase-targeted recombinant bacterial protein toxins are a sort of rationally designed and engineered anticancer recombinant fusion proteins representing a novel class of agents for cancer therapy.Bacterial protein toxins have long been known as the primary virulence factor(s)for a variety of pathogenic bacteria and are the most powerful human poisons.On the other hand,it has been well documented that urokinase-type plasminogen activator(uPA)and urokinase plasminogen activator receptor(uPAR),making up the uPA system,are overexpressed in a variety of human tumors and tumor cell lines.The expression of uPA system is highly correlated with tumor invasion and metastasis.To exploit these characteristics in the design of tumor cell-selective cytotoxins,two prominent bacterial protein toxins,i.e.,the diphtheria toxin and anthrax toxin are deliberately engineered through placing a sequence targeted specifically by the uPA system to form anticancer recombinant fusion proteins.These uPA system-targeted bacterial protein toxins are activated selectively on the surface of uPA systemexpressing tumor cells,thereby killing these cells.This article provides a review on the latest progress in the exploitation of these recombinant fusion proteins as potent tumoricidal agents.It is perceptible that the strategies for cancer therapy are being innovated by this novel therapeutic approach.