Hodgkin's lymphoma:2023 update on treatment

Hodgkin's lymphoma(HL)is a common,malignant hematological tumor of the lymph nodes and lymphatic system,accounting for 10%of all lymphomas.HL comprises 2 main subtypes:classical HL(cHL)and nodular lymphocyte predominant HL.

A retrospective analysis of mature T-and NK-cell lymphomas

Mature T-and natural killer(NK)-cell lymphomas are heterogeneous groups of malignant lymphoid neoplasms arising from T and NK cells. The incidence of mature T-and NK-cell lymphomas is 2.1 per 100,000 people, according to a US report~1.

The accessible seismological dataset of a high-density 2D seismic array along Anninghe fault

The scientific goal of the Anninghe seismic array is to investigate the detailed geometry of the Anninghe fault and the velocity structure of the fault zone.This 2D seismic array is composed of 161 stations forming sub-rectangular geometry along the Anninghe fault,which covers 50 km and 150 km in the fault normal and strike directions,respectively,with~5 km intervals.The data were collected between June 2020 and June 2021,with some level of temporal gaps.Two types of instruments,i.e.QS-05A and SmartSolo,are used in this array.Data quality and examples of seismograms are provided in this paper.After the data protection period ends(expected in June 2024),researchers can request a dataset from the National Earthquake Science Data Center.

A high-resolution seismic catalog for the 2021 M_(S)6.4/M_(W)6.1 Yangbi earthquake sequence, Yunnan, China: Application of AI picker and matched filter

We present a high-resolution seismic catalog for the 2021 M_(S)6.4/M_(W)6.1 Yangbi sequence.The catalog has a time range of 2021-05-01 to 2021-05-28,and contains~8,000 well located events.It captures the features of the whole foreshock sequence and the early aftershocks.We designed a detection strategy incorporating both an artificial intelligent(AI)picker and a matched filter algorithm.Here,we adopt a hybrid AI method incorporating convolutional and recurrent neural network(CNN&RNN)for event detection and phase picking respectively(i.e.CERP),a light-weight AI picker that can be trained with small volume of data.CERP is first trained with detections from a STA/LTA and Kurtosis-based method called PAL,and then construct a rather complete template set of~4,000 events.Finally,the matched filter algorithm MESS augments the initial detections and measures differential travel times with cross-correlation,which finally results in precise relocation.This process gives 9,026 detections,among which 7,943 events can be well relocated.The catalog shows as expected power-law distribution of frequency magnitude and reveals detailed pattern of seismicity evolution.The main features are:(1)the foreshock sequence images simple fault geometry with consistent strike,but also show a variable event depth along strike;(2)the mainshock ruptures the same fault of the foreshock sequence and activate conjugate faults further to the southeast;(3)complex seismicity are developed in the post-seismic period,indicating complex triggering mechanisms.Thus,our catalog provides a reliable basis for further investigations,such as b-value studies,rupture process,and triggering relations.

A test on methods for MC estimation based on earthquake catalog

This study tested five methods widely used in estimating the complete magnitudes(M_C) of earthquake catalogs. Using catalogs of observed earthquake properties, we test the performance of these five algorithms under several challenging conditions, such as small volume of events and spatial-temporal heterogeneity, in order to see whether the algorithms are stable and in agreement with known data. We find that the maximum curvature method(MAXC) has perfect stability, but will significantly underestimate M_C unless heterogeneity is absent. M_C estimated by the b-value stability method(MBS) requires many events to reach a stable result. Results from the goodness of fit method(GFT) were unstable when heterogeneity lowered the fitness level. The entire magnitude range method(EMR) is relatively stable in most conditions, and can reflect the change in M_C when heterogeneity exists, but when the incomplete part of the earthquake catalog is dismissed, this method fails. The median-based analysis of the segment slope method(MBASS) can tolerate small sample size, but is incapable of reflecting the missing degree of small events in aftershock sequences. In conditions where M_C changes rapidly, such as in aftershock sequences, observing the time sequence directly can give a precise estimation of the complete sub-catalog, but only when the number of events available for study is large enough can the MAXC, GFT, and MBS methods give a similarly reliable estimation.

The spatiotemporal variation of the b-value and its tectonic implications in North China

In this study, we adopt an improved Bayesian approach based on free-knot B-spline bases to study the spatial and temporal distribution of the b-value. Synthetic tests show that the improved Bayesian approach has a superior performance compared to the Bayesian approach as well as the widely used maximum likelihood estimation （MLE） method in fitting the real variation of b-values. We then apply the improved Bayesian approach to North China and find that the b-value has a clear relevance to seismicity. Temporal changes of b-values are also investigated in two specific areas of North China. We interpret sharp decreases in the b-values as useful messages in earthquake hazard analysis.

Doppler effect of the rupture process of the great M_W7.9 Wenchuan earthquake

In this study we performed a classical spectrum analysis of seismic waveforms recorded at far field stations of the great MW7.9 Wenchuan earthquake to observe the shifts of the corner frequency with azimuth due to the Doppler effect.Our results show that this damaging great earthquake had a dominating rupture propagation direction of 64.0°.The equivalent radius of the fault rupture surface was estimated to be 33 km,yielding the rupture area of about 3 500 km2.Thus the length of the rupture fault surface is about 230 km if the depth（or width） extent is 15 km.The computer program developed in this study can quickly provide the information about the source of a future large（damaging） earthquake,which could be very useful for predicting aftershocks and planning the rescue operations.

Mantle anisotropy across the southwestern boundary of the Ordos block,North China

Located at the northeastern margin of the Tibetan plateau,the Ordos block is a stable tectonic unit in North China.With its active boundary fault zones,the Ordos block played an important role in the eastward extrusion mechanism of the Tibetan plateau.Peking University deployed a linear array of 15 portable broadband seismometers across the western Weihe graben during September 2005 to August 2006 and later a 2-D seismic array（Southwest Ordos Array） of 14 portable broadband seismometers during 2007-2008 at its southwestern boundary.Analyses of shear wave splitting of SKS and SKKS phases at these stations show that the fast directions trend ～110° with an average delay time of 0.9 s in the southwestern margin of the Ordos block.The agreement between the lithosphere deformation indicated by GPS data and Quaternary fault slip-rate observations and the mantle flow represented by shear wave splitting implies that accordant deformation patterns from lithosphere to asthenosphere in relation to the eastward extrusion of the Tibetan plateau could extend at least to 200 km depth.Spatial distribution of splitting polarization directions indicates that the mantle flow driven by the Tibetan plateau is blocked by the Ordos block and locally restricted in a narrow channel along the Qinling-Dabie fault zones between the Ordos block and Sichuan basin.

基于肿瘤浸润免疫细胞的弥漫性大B细胞淋巴瘤预后模型的构建及初步评价

目的:探索免疫化疗时代基于多种肿瘤浸润免疫细胞建立弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)预后模型并进行初步评价。方法:采用ImmuCellAI算法计算DLBCL肿瘤微环境中24种免疫细胞的丰度,通过(least absolute shrinkage and selection operator,LASSO)回归和Cox回归筛选预测变量并构建基于免疫细胞的风险评分模型(immune cells-based risk scores,IRS)模型。同时将IRS模型与患者临床因素相结合,构建IRSC模型。采用Kaplan-Meier法和ROC曲线评估该模型,采用列线图计算不同时间点的生存率。结果:IRS模型高风险组患者总生存时间(OS)明显低于低风险组[P=1e-15,HR=0.298(0.2176~0.4082)],基于患者1、3、5年生存情况的ROC曲线AUC值分别为0.728、0.711和0.615,且该模型风险评分与免疫检查点抑制剂(immune checkpoint inhibitors,ICPIs)疗效呈负相关。IRSC模型较IRS模型预测效果更佳:高风险组预后显著差于低风险组P<2e-16,HR=0.170(0.1143~0.253)],基于患者1、3、5年生存情况的ROC曲线AUC值分别为0.797、0.809和0.792。结论:IRS模型能很好的预测DLBCL患者的预后及对ICPIs的疗效,而IRSC模型预后价值更高。

Discussion on 'Was the 2008 Wenchuan earthquake triggered by Zipingpu Reservoir?'

Some recent publications presented a result suggesting that Zipingpu reservoir hastened the occurrence of the 2008 Ms8.0 Wenchuan earthquake by tens to hundreds of years. Their researches calculated the Coulomb stress change induced by Zipingpu reservoir on the rupturing fault of Wenchuan earthquake. Their results, however, are critically dependent upon the 3-D event location, reservoir location, and the fault plane orientation. We repeated Ge et al.＇s work in this paper and found that an improper dip angle parameter of their 2-D fault model might lead to a wrong conclusion. Both the modeling results based on the 2-D model and 3-D model with proper fault parameters will show Coulomb stress changes alone were neither large enough nor had the correct orientation to affect the occurrence of Wenchuan earthquake, which supports our recent argument based on the local seismicity analysis and the induced Coulomb stress change calculation with a 3-D model.

Inferring seismic hazard in Sichuan-Yunnan region of China based on the modern earthquake catalogue (1980-2019)

Based on the modern earthquake catalogue,the incomplete centroidal voronoi tessellation(ICVT)method was used in this study to estimate the seismic hazard in Sichuan-Yunnan region of China.We calculated spatial distributions of the total seismic hazard and background seismic hazard in this area.The Bayesian delaunay tessellation smoothing method put forward by Ogata was used to calculate the spatial distributions of b-value.The results show that seismic hazards in Sichuan-Yunan region are high,and areas with relatively high hazard values are distributed along the main faults,while seismic hazards in Sichuan basin are relatively low.

1976年中国唐山地震序列的应力相互作用

研究了1976年中国唐山MS7·8级地震两个主震事件和两个最大余震之间的静态应力相互作用。断层参数取自前人大地测量和远震波形反演结果。对于序列中的每个事件,我们计算了前面所有事件产生的包括孔隙压力变化的库仑破裂应力(CFS)变化。我们发现,在所有情况下,对于最优的力学参数得到的增加的库仑应力变化几乎涵盖了有关的整个断层。我们认为,应力相互作用在确定主震以外地区中何处可能发生大余震是很重要的。快速确定主震位置和机制,并结合对附近主要断层的认识,对后续事件的危险性评估是有用的。

Distribution of the low velocity bulk in the middle-to-lower crust of southern Tibet: implications for formation of the north–south trending rift zones

We conducted the ambient noise tomography to image the shallow crustal structure of southern Tibet. The2D maps of phase velocity anomalies at the periods of10–16 s show that the low velocities are mainly confined along or near some of the rift zones. While the maps at the periods of 18–25 s show that the coherent patterns that the low velocities expand outside of the rift zones. It means that the low velocities are prevailing in the middle crust of southern Tibet. According to the previous study of surface wave tomography with teleseismic data,we find that the low velocities from the lower crust to the lithospheric mantle are also restricted to the same rift zones. Thus,the integrated knowledge of the distribution of the low velocities in southern Tibet provides some new insight on the formation of the north–south trending rift zones. Compiling the multidiscipline evidences,we conclude that the rifting was an integrated process of the entire lithosphere in the early stage（＊26–10 Ma）,but mainly occurred within the upper crust due to the weakening a decoupling in the low velocity middle crust in the late stage（later than ＊8 Ma）.

Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response

During maturation, murine myeloid dendritic cells （DCs） upregulated the expressions of CDllc, CD25, CD40, CD80, CD86, MHC Ⅱ and programmed death 1 ligands 1 and 2 （PD-L1 and PD-L2）. Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-α. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs, whereas TNF-α stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2, CD40-1igated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation. Cellular ＆ Molecular Immunology.

Application and discussion of statistical seismology in probabilistic seismic hazard assessment studies

Earthquakes are one of the natural disasters that pose a major threat to human lives and property. Earthquake prediction propels the construction and development of modern seismology;however, current deterministic earthquake prediction is limited by numerous difficulties. Identifying the temporal and spatial statistical characteristics of earthquake occurrences and constructing earthquake risk statistical prediction models have become significant;particularly for evaluating earthquake risks and addressing seismic planning requirements such as the design of cities and lifeline projects based on the obtained insight. Since the 21 st century, the occurrence of a series of strong earthquakes represented by the Wenchuan M8 earthquake in 2008 in certain low-risk prediction areas has caused seismologists to reflect on traditional seismic hazard assessment globally. This article briefly reviews the development of statistical seismology, emphatically analyzes the research results and existing problems of statistical seismology in seismic hazard assessment, and discusses the direction of its development. The analysis shows that the seismic hazard assessment based on modern earthquake catalogues in most regions should be effective. Particularly, the application of seismic hazard assessment based on ETAS(epidemic type aftershock sequence)should be the easiest and most effective method for the compilation of seismic hazard maps in large urban agglomeration areas and low seismic hazard areas with thick sedimentary zones.