急性缺血性脑卒中的血管内介入治疗疗效分析

目的分析血管内介入治疗对急性脑卒中的临床疗效。方法收集我院2017年6月-2019年8月收治的42例急性缺血性脑卒中患者作为实验对象,治疗方案为血管内介入治疗,评定临床疗效和安全性。结果42例患者术后头颅CT复查结果显示,血管再通率达76.2%(32/42);治疗后NIHSS评分同治疗前的NIHSS评分比较,差异有统计学意义(P<0.05);术后出现症状性脑出血2例,大面积脑梗死1例。连续治疗1个月后进行MRI复查,结果显示脑梗死范围减小明显。结论血管内介入治疗能够对急性缺血性脑卒中患者的病情进行良好改善,切实提高治疗效果,促进血管再通具有临床借鉴和推广价值。

Early prediction of growth patterns after pediatric kidney transplantation based on height-related single-nucleotide polymorphisms

Background:Growth retardation is a common complication of chronic kidney disease in children,which can be partially relieved after renal transplantation.This study aimed to develop and validate a predictive model for growth patterns of children with end-stage renal disease(ESRD)after kidney transplantation using machine learning algorithms based on genomic and clinical variables.Methods:A retrospective cohort of 110 children who received kidney transplants between May 2013 and September 2021 at the First Affiliated Hospital of Zhengzhou University were recruited for whole-exome sequencing(WES),and another 39 children who underwent transplant from October 2021 to March 2022 were enrolled for external validation.Based on previous studies,we comprehensively collected 729 height-related single-nucleotide polymorphisms(SNPs)in exon regions.Seven machine learning algorithms and 10-fold cross-validation analysis were employed for model construction.Results:The 110 children were divided into two groups according to change in height-for-age Z-score.After univariate analysis,age and 19 SNPs were incorporated into the model and validated.The random forest model showed the best prediction efficacy with an accuracy of 0.8125 and an area under curve(AUC)of 0.924,and also performed well in the external validation cohort(accuracy,0.7949;AUC,0.796).Conclusions:A model with good performance for predicting post-transplant growth patterns in children based on SNPs and clinical variables was constructed and validated using machine learning algorithms.The model is expected to guide clinicians in the management of children after renal transplantation,including the use of growth hormone,glucocorticoid withdrawal,and nutritional supplementation,to alleviate growth retardation in children with ESRD.

Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope

The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety of small molecule PROTACs have entered the clinical trial.However,as small molecule PROTACs flourish,non-small molecule PROTACs(NSM-PROTACs)such as peptide PROTACs,nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years,exhibiting the unique characters beyond the small molecule PROTACs.Here,we briefly introduce the types of NSM-PROTACs,describe the advantages of NSM-PROTACs,and summarize the development of NSM-PROTACs so far in detail.We hope this article could not only provide useful insights into NSM-PROTACs,but also expand the research interest of NSM-PROTACs.

Effects of support acidity on the reaction mechanisms of selective catalytic reduction of NO by CH_(4) in excess oxygen

The reaction mechanisms of selective catalytic reduction(SCR)of nitric oxide(NO)by methane(CH4)over solid superacid-based catalysts were proposed and testified by DRIFTS studies on transient reaction as well as by kinetic models.Catalysts derived from different supports would lead to different reaction pathways,and the acidity of solid superacid played an important role in determining the reaction mechanisms and the catalytic activities.Higher ratios of BrØnsted acid sites to Lewis acid sites would lead to stronger oxidation of methane and then could facilitate the step of methane activation.Strong BrØnsted acid sites would not necessarily lead to better catalytic performance,however,since the active surface NO_(y) species and the corresponding reaction routes were determined by the overall acidity strength of the support.The reaction routes where NO_(2)moiety was engaged as an important intermediate involved moderate oxidation of methane,the rate of which could determine the overall activity.The reaction involving NO moiety was likely to be determined by the step of reduction of NO.Therefore,to enhance the SCR activity of solid superacid catalysts,reactions between appropriate couples of active NO_(y)species and activated hydrocarbon intermediates should be realized by modification of the support acidity.

Local modulation of exc辻ons and trions in monolayer WS2 by carbon nanotubes

Mixed dimensional van der Waals(VdW)heterostructures constructed by one-dimensional(1D)and two-dimensional(2D)materials exhibit extra degree of freedom to modulate the electronic and optical properties due to the combination of difterent dimensionalities.The charge transfer at the intertace between 1D and 2D materials plays a crucial role in the optoelectronic properties and performance of the heterostructure-based devices.Here,we stacked single-walled carbon nanotubes(SWNTs)on monolayer WS2 for a mixed dimensional vdW heterostructure,and investigated the local modulation of excitions and trions in WS2 by SWNTs.Different directions of charge transfer between SWNTs and WSz are evidenced by the photoluminescence(PL)spectra of WS2.The PL intensity can be either enhanced or weakened by individual SWNTs.In our work,the PL intensity of WS2 is enhanced and the exciton peak position heterostructure is red-shifted about 3 meV due to the charge transfer from WS2 to an individual SWNT(SWNT#1).The change of PL by another SWNT(SWNT#2)can not be well-resolved in far fild,but scanning near field optical microscope(SNOM)measurements show that the PL intensity of WS2 is weakened by the SWNT.The peak position of exciton is blue-shifted by^1 meV while that of trion is redshifted by^1 meV due to the charge transfer from the SWNT to WS2,These results give insight into the charge transfer at the interface of SWNTWS2 heterostructure,and can be useful for design of optoelectronic devices based on mixed dimensional vdW heterostructures.

A parametrized compactness theorem under bounded Ricci curvature

We prove a parametrized compactness theorem on manifolds of bounded Ricci curvature, upper bounded diameter, and lower bounded injectivity radius.