Triple-negative breast cancer(TNBC)is an aggressive subtype characterized by extensive tumor heterogeneity,with limited treatment options and a poor prognosis.1 We used cell type annotation and trajectory analysis to ...Triple-negative breast cancer(TNBC)is an aggressive subtype characterized by extensive tumor heterogeneity,with limited treatment options and a poor prognosis.1 We used cell type annotation and trajectory analysis to identify two distinct differentiation states of epithelial cells,while tumor cells predominantly resided on one of these branches.Inferring the malignant state of epithelial cells based on copy number variation,280 tumor cells were eventually identified from epithelial cells.Differential genes between tumor cells and non-tumor cells were mainly enriched in immune-related functions and pathways.展开更多
基金supported by the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province,China(No.UNPYSCT-2020174)Excellent Youth Project of Provincial Scientific Research Institute(Heilongjiang,China)(No.CZKYF2022-1-C006)the Hei Long Jiang Postdoctoral Special Foundation(China)(No.LBH-TZ1018).
文摘Triple-negative breast cancer(TNBC)is an aggressive subtype characterized by extensive tumor heterogeneity,with limited treatment options and a poor prognosis.1 We used cell type annotation and trajectory analysis to identify two distinct differentiation states of epithelial cells,while tumor cells predominantly resided on one of these branches.Inferring the malignant state of epithelial cells based on copy number variation,280 tumor cells were eventually identified from epithelial cells.Differential genes between tumor cells and non-tumor cells were mainly enriched in immune-related functions and pathways.
