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结直肠癌术后辅助卡培他滨为基础化疗方案的临床疗效及相关药物基因组学分析 被引量:6
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作者 刘世举 张慧俭 +4 位作者 王金榜 杨会举 张新春 刘翔 刘佃温 《中国肿瘤临床》 CAS CSCD 北大核心 2018年第17期889-893,共5页
目的:本研究旨在探讨结直肠癌(colorectal cancer,CRC)术后辅助卡培他滨为基础化疗方案的疗效及相关药物基因组学分析。方法:回顾性分析2010年1月至2017年6月河南中医药大学第三附属医院收治术后接受辅助化疗的CRC患者215例。收集外周... 目的:本研究旨在探讨结直肠癌(colorectal cancer,CRC)术后辅助卡培他滨为基础化疗方案的疗效及相关药物基因组学分析。方法:回顾性分析2010年1月至2017年6月河南中医药大学第三附属医院收治术后接受辅助化疗的CRC患者215例。收集外周血提取DNA用来进行胞苷脱氨酶(cytidine deaminase,CDD)多态性位点基因分型。另外,收集85例患者的化疗前外周血单核细胞(peripheral blood mononuclear cell,PBMC)提取RNA对CDD的m RNA表达水平进行测定。结果:215例患者具有良好的疗效。药物基因组学分析方面,发现CDD基因启动子区域的多态性位点-451C>A和疗效相关,该位点GA/AA和GG基因型患者的3年无疾病生存率(disease-free survival,DFS)分别为81.03%和62.42%,差异具有统计学意义(P=0.002)。两种基因型患者的5年总生存率(overall survival,OS)分别为72.41%和53.50%,差异具有统计学意义(P=0.016)。在85例患者外周血单核细胞的mRNA表达分析中发现,携带A等位基因的患者相对于GG型患者,外周血单核细胞中CDD的mRNA表达明显较高,差异具有统计学意义(P<0.001)。结论:卡培他滨为基础的化疗方案具有良好的治疗效果。CDD基因-451C>A位点可能通过影响该基因m RNA的表达使CRC患者从卡培他滨的治疗当中获益。 展开更多
关键词 结直肠癌 胞苷脱氨酶 多态性 疗效
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Comparison of Formation Conditions of Source Rocks of Fengcheng and Lucaogou Formations in the Junggar Basin,NW China:Implications for Organic Matter Enrichment and Hydrocarbon Potential 被引量:1
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作者 shiju liu Gang Gao +3 位作者 Wenzhe Gang Baoli Xiang Ming Wang Chengyun Wang 《Journal of Earth Science》 SCIE CAS CSCD 2023年第4期1026-1040,共15页
Shales in the Carboniferous–Permian Fengcheng(FC) and Lucaogou(LCG) formations in Junggar Basin are important organic rich rocks containing significant oil resources.To evaluate the difference in sedimentary environm... Shales in the Carboniferous–Permian Fengcheng(FC) and Lucaogou(LCG) formations in Junggar Basin are important organic rich rocks containing significant oil resources.To evaluate the difference in sedimentary environment conditions and hydrocarbon-generating potential between the FC and LCG formations.Total organic carbon(TOC),Rock-Eval pyrolysis,solvent extraction,column fractionation,stable carbon isotope,gas chromatography-mass spectrometry(GC-MS) of saturated hydrocarbons and organic petrology from the source rocks of FC and LCG formations.were analyzed.The biomarker composition indicates that during the deposition of FC,LCG-1 to LCG-2,the sedimentary environment for the source rock formations changed with gradual decrease of salinity,from anoxic to dyoxic/suboxic in redox conditions,and from strong stratification to weakened stratification of water.The FC Formation source rock,with main telalginite(planktonic green algae),archaebacteria and minor terrestrial organic matter,deposited in the environment characterized by high salinity and strongly reducing condition.Its TOC content is relatively low with a high original hydrocarbongenerating potential of unit organic material.The LCG Formation source rock deposited in the environment with low salinity and large variations,the organic matter is mainly sourced from telalginite(planktonic green algae),lamalginite,bacteria and higher plants,resulting in strong heterogeneity of the source rock.The abundance of TOC is high,but the original hydrocarbon generation potential of unit organic matter is lower than that of FC Formation.The results provide a geochemical basis for further study of saline-brackish water sedimentary environment shales in the Junggar Basin. 展开更多
关键词 geochemistry biogenic precursors depositional conditions Fengcheng Formation LucaogouFormation JunggarBasin.
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