Oral squamous cell carcinoma(OSCC)escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors.As a hallmark of cancer,DNA damage...Oral squamous cell carcinoma(OSCC)escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors.As a hallmark of cancer,DNA damage repair is closely related to changes in the immunophenotypes of tumor cells.Although flap endonuclease-1(FEN1),a pivotal DNA-related enzyme is involved in DNA base excision repair to maintain the stability of the cell genome.展开更多
Although temperature extremes have led to more and more disasters, there are as yet few studies on the extremes and many disagreements on temperature changes in Antarctica. Based on daily minimum, maximum, and mean ai...Although temperature extremes have led to more and more disasters, there are as yet few studies on the extremes and many disagreements on temperature changes in Antarctica. Based on daily minimum, maximum, and mean air temperatures(Tmin, Tmax, Tmean) at Great Wall Station(GW) and Zhongshan Station(ZS), we compared the temperature extremes and revealed a strong warming trend in Tmin, a slight warming trend in Tmean, cooling in Tmax, a decreasing trend in the daily temperature range, and the typical characteristic of coreless winter temperature. There are different seasonal variabilities, with the least in summer. The continentality index and seasonality show that the marine air mass has more effect on GW than ZS. Following the terminology of the Fifth Assessment Report of the Intergovernmental Panel on Climate Change(IPCC AR5), we defined nine indices of temperature extremes, based on the Antarctic geographical environment. Extreme-warm days have decreased, while extreme-warm nights have shown a nonsignificant trend. The number of melting days has increased at GW, while little change at ZS. More importantly, we have found inverse variations in temperature patterns between the two stations, which need further investigation into the dynamics of climate change in Antarctica.展开更多
基金supported by the National Natural Science Foundation of China(No.82071124,82002884,82101028,82102854)。
文摘Oral squamous cell carcinoma(OSCC)escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors.As a hallmark of cancer,DNA damage repair is closely related to changes in the immunophenotypes of tumor cells.Although flap endonuclease-1(FEN1),a pivotal DNA-related enzyme is involved in DNA base excision repair to maintain the stability of the cell genome.
基金funded by the National Natural Science Foundation of China (Grant Nos. 41476164, 41671073, 41425003, and 41671063)the State Key Laboratory of Cryospheric Science
文摘Although temperature extremes have led to more and more disasters, there are as yet few studies on the extremes and many disagreements on temperature changes in Antarctica. Based on daily minimum, maximum, and mean air temperatures(Tmin, Tmax, Tmean) at Great Wall Station(GW) and Zhongshan Station(ZS), we compared the temperature extremes and revealed a strong warming trend in Tmin, a slight warming trend in Tmean, cooling in Tmax, a decreasing trend in the daily temperature range, and the typical characteristic of coreless winter temperature. There are different seasonal variabilities, with the least in summer. The continentality index and seasonality show that the marine air mass has more effect on GW than ZS. Following the terminology of the Fifth Assessment Report of the Intergovernmental Panel on Climate Change(IPCC AR5), we defined nine indices of temperature extremes, based on the Antarctic geographical environment. Extreme-warm days have decreased, while extreme-warm nights have shown a nonsignificant trend. The number of melting days has increased at GW, while little change at ZS. More importantly, we have found inverse variations in temperature patterns between the two stations, which need further investigation into the dynamics of climate change in Antarctica.
