Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative Staphylococcus comprising the normal skin microbiota,primarily colonizing the lower abdomen and extremities.[1]S.lugdunensis has attracted substantial a...Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative Staphylococcus comprising the normal skin microbiota,primarily colonizing the lower abdomen and extremities.[1]S.lugdunensis has attracted substantial attention in recent years since the discovery of lugdunin by Zipperer et al[2]in 2016.Lugdunin is a secondary metabolite synthesized by non-ribosomal peptide synthetase(NRPS)that inhibits the growth of various grampositive bacteria,including methicillin-resistant S.aureus(MRSA),[2]suggesting its potential as an antibiotic.展开更多
基金National Science and Technology Major Project of China(No.2017ZX10103004-006)National Key Research and Development Programme of China(No.2016YFC0903800)
文摘Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative Staphylococcus comprising the normal skin microbiota,primarily colonizing the lower abdomen and extremities.[1]S.lugdunensis has attracted substantial attention in recent years since the discovery of lugdunin by Zipperer et al[2]in 2016.Lugdunin is a secondary metabolite synthesized by non-ribosomal peptide synthetase(NRPS)that inhibits the growth of various grampositive bacteria,including methicillin-resistant S.aureus(MRSA),[2]suggesting its potential as an antibiotic.
