In molecular modeling of electrical double layers(EDLs),the constant charge method(CCM)is prized for its computational efficiency but cannot maintain electrode equipotentiality like the more resourceintensive constant...In molecular modeling of electrical double layers(EDLs),the constant charge method(CCM)is prized for its computational efficiency but cannot maintain electrode equipotentiality like the more resourceintensive constant potential method(CPM),potentially leading to inaccuracies.In certain scenarios,CCM can yield results identical to CPM.However,there are no clear guidelines to determine when CCM is sufficient and when CPM is required.Here,we conduct a series of molecular simulations across various electrodes and electrolytes to present a comprehensive comparison between CCM and CPM under different charging modes.Results reveal that CCM approximates CPM effectively in capturing equilibrium EDL and current-driven dynamics in open electrode systems featuring ionic liquids or regular concentration aqueous electrolytes,while CPM is indispensable in scenarios involving organic and highly concentrated aqueous electrolytes,nanoconfinement effects,and voltage-driven dynamics.This work helps to select appropriate methods for modeling EDL systems,prioritizing accuracy while considering computationalefficiency.展开更多
Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellul...Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch.展开更多
Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the cl...Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods: 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results: Among the 15 cases (10 males and 5 females), the age ranged from 22 to 74 years old (the mean age was 50.67-year old). The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions: Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients.展开更多
Background To solve the problem of visualization in augmented reality(AR),for assembly process information,we report here on our study into the composition of AR assembly process information.Methods Our work led us to...Background To solve the problem of visualization in augmented reality(AR),for assembly process information,we report here on our study into the composition of AR assembly process information.Methods Our work led us to classify the visual elements of assembly processes into six categories,and after looking further into visual element expression characteristics used in assembly process information in the AR environment,standard assembly process elements have been identified and visual element layout principles studied.Conclusion Typical visualization elements have been presented,using an AR-based assembly instruction system.展开更多
Inspired by the successful synthesis of h Hv-graphane[Nano Lett.15903(2015)],a new two-dimensional(2D)Janus material Cu-graphane is proposed based on the first-principles calculations.Without the spin-orbit coupling(S...Inspired by the successful synthesis of h Hv-graphane[Nano Lett.15903(2015)],a new two-dimensional(2D)Janus material Cu-graphane is proposed based on the first-principles calculations.Without the spin-orbit coupling(SOC)effect,Cu-graphane is a Dirac semimetal with a highly anisotropic Dirac cone,whose Fermi velocity ranges from 0.12×10^(5)m/s to2.9×10^(5)m/s.The Dirac cone near the Fermi level can be well described with an extended 2D Dirac model Hamiltonian.In the presence of the SOC effect,band splitting is observed around the Fermi level,and a large intrinsic spin Hall conductivity(ISHC)with a maximum value of 346(h/e)S/cm is predicted.Moreover,the spin Hall transport can be regulated by slightly adjusting the Fermi energy,e.g.,grid voltage or chemical doping.Our work not only proposes a new 2D Janus material with a highly anisotropic Dirac cone and a large ISHC,but also reveals that a large ISHC may exist in some Dirac systems.展开更多
In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vap...In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vapor enucleation and resection of the prostate(TVERP),transurethral vapor enucleation of the prostate(TVEP),and ultrasound-navigated TVEP(US-TVEP)are new,innovative endoscopic enucleation procedures.These procedures are named Xie’s Prostate Enucleations(Xie’s Procedures for short).Current clinical data indicate that Xie’s Procedures are safe and effective treatment options for patients with BPH,especially for patients with larger prostates.Further prospective,randomized clinical trials compared with traditional transurethral resection of prostate(TURP)are still needed.展开更多
Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has al...Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has also been shown to promote an immunosuppressive tumor microenvironment.Previous studies demonstrated that focal adhesion kinase inhibitors(FAKi)in clinical development inhibit the infiltration of suppressive myeloid cells and T regulatory(T regs)cells,and subsequently enhance effector T cell infiltration.FAK inhibitors in clinical development have not been investigated in combination with RT in preclinical murine models or clinical studies.Thus,we investigated the impact of FAK inhibition on RT,its potential as an RT sensitizer and immunomodulator in a murine model of PDAC.Methods:We used a syngeneic orthotopic murine model to study the effect of FAKi on hypofractionated RT.Results:In this study we showed that IN10018,a small molecular FAKi,enhanced antitumor response to RT.Antitumor activity of the combination of FAKi and RT is T cell dependent.FAKi in combination with RT enhanced CD8+T cell infiltration significantly in comparison to the radiation or FAKi treatment alone(P<0.05).FAKi in combination with radiation inhibited the infiltration of granulocytes but enhanced the infiltration of macrophages and T regs in comparison with the radiation or FAKi treatment alone(P<0.01).Conclusions:These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy.展开更多
Vaporization behavior (1163-1463 K) of lead in the slag system of FeO-CaO-SiO2-Al2O3 with CaC% was examined. A thermodynamic estimation with the principle of Gibbs free energy minimization showed that the major vapo...Vaporization behavior (1163-1463 K) of lead in the slag system of FeO-CaO-SiO2-Al2O3 with CaC% was examined. A thermodynamic estimation with the principle of Gibbs free energy minimization showed that the major vapor species from the sample of the FeO-CaO-SiO2-Al2O3 system+PbO+CaCl2 were metallic Pb, PbCl, PbCl2, and FeCl2, at the experimental temperature range. The experimental results show that the mole ratio of vaporized Cl in lead chlorides to vaporized Pb, simply expressed as Cl/Pb decreases with increasing temperature. The larger Cl/Pb means a larger ratio of gaseous PbCl2, since metallic Pb and PbCl vapors are formed in a similar reduction atmosphere. The evaporation is initially rapid and becomes steady after holding for 10 min. Gaseous PbCl2 is mainly formed during the heating period, and at the holding stage, it reacts with FeO to produce gaseous FeCl2 With regard to slag composition, FeO content and basicity significantly affect the evaporation of lead. High FeO content and high basicity promotes the formation of metallic Pb and PbCI, whereas, it prohibits PbCl2 evaporation.展开更多
To improve the efficiency of cathodic oxygen reduction reaction(ORR)in zinc-air batteries(ZABs),an adsorption-complexation-calcination method was proposed to generate cobalt-based multicomponent nanoparticles comprisi...To improve the efficiency of cathodic oxygen reduction reaction(ORR)in zinc-air batteries(ZABs),an adsorption-complexation-calcination method was proposed to generate cobalt-based multicomponent nanoparticles comprising Co,Co_(3)O_(4)and CoN,as well as numerous N heteroatoms,on graphene nanosheets(Co/Co_(3)O_(4)/CoN/NG).The Co/Co_(3)O_(4)/CoN nanoparticles with the size of less than 50 nm are homogeneously dispersed on N-doped graphene(NG)substrate,which greatly improve the catalytic behaviors for ORR.The results show that the half-wave potential is as high as 0.80 V vs.RHE and the limiting current density is 4.60 mA·cm^(−2),which are close to those of commercially available platinum/carbon(Pt/C)catalysts.Applying as cathodic catalyst for ZABs,the battery shows large specific capacity and open circuit voltage of 843.0 mAh∙g^(−1) and 1.41 V,respectively.The excellent performance is attributed to the efficient two-dimensional structure with high accessible surface area and the numerous multiple active sites provided by highly scattered Co/Co_(3)O_(4)/CoN particles and doped nitrogen on the carbon matrix.展开更多
In order to develop super-board and super-thick slabs, the flow and temperatur fields were studied in slab continuous casting molds under different practical conditions, such as slab dimensions, with-drawing slab spee...In order to develop super-board and super-thick slabs, the flow and temperatur fields were studied in slab continuous casting molds under different practical conditions, such as slab dimensions, with-drawing slab speed, design of nozzles, and superheat tempera-ture. The results showed that it is preferred to incline nozzle bores downwards and the submerged depth of the nozzles is best kept be-tween 250-300 mm. In addition, the solidified shell is thicker at the wide face than that at the narrow face, while the thin points alongthe wide face ekist both in the center and in the some area toward each respective end.展开更多
Globally,infertility is a serious health problem affecting about 15%of reproductive age couples according to the data reported by the World Health Organization.Non-obstructive azoospermia(NOA)is acknowledged as one of...Globally,infertility is a serious health problem affecting about 15%of reproductive age couples according to the data reported by the World Health Organization.Non-obstructive azoospermia(NOA)is acknowledged as one of the most serious phenotypes of male infertility.Approximately 1%of the male population and 10%of infertile men were affected by NOA(Xie et al.,2022).As reported,meiotic arrest is one of the major etiologies leading to the NOA.展开更多
The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells enginee...The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor(CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.展开更多
Starch is the predominant compound in bulb scales,and previous studies have shown that bulblet development is closely associated with starch enrichment.However,how starch synthesis affects bulbification at the molecul...Starch is the predominant compound in bulb scales,and previous studies have shown that bulblet development is closely associated with starch enrichment.However,how starch synthesis affects bulbification at the molecular level is unclear.In this study,we demonstrate that Lilium brownii var.giganteum,a wild lily with a giant bulb in nature,and L.brownii,the native species,have different starch levels and characteristics according to cytological and ultra-structural observations.We cloned the complete sequence of three key gene-encoding enzymes(LbgAGPS,LbgGBSS,and LbgSSⅢ)during starch synthesis by rapid amplification of 5’and 3’complementary DNA(cDNA)ends(RACE)technology.Bioinformatics analysis revealed that the proteins deduced by these genes contain the canonical conserved domains.Constructed phylogenetic trees confirmed the evolutionary relationships with proteins from other species,including monocotyledons and dicotyledons.The transcript levels of various tissues and time course samples obtained during bulblet development uncovered relatively high expression levels in bulblets and gradual increase expression accompanying bulblet growth.Moreover,a set of single nucleotide polymorphisms(SNPs)was discovered in the AGPS genes of four lily genotypes,and a purifying selection fashion was predicted according to the non-synonymous/synonymous(Ka/Ks)values.Taken together,our results suggested that key starch-synthesizing genes might play important roles in bulblet development and lead to distinctive phenotypes in bulblet size.展开更多
Polysulfide shuttle effect,causing extremely low Coulombic efficiency and cycling stability,is one of the toughest challenges hindering the development of practical lithium sulfur batteries(LSBs).Introducing catalytic...Polysulfide shuttle effect,causing extremely low Coulombic efficiency and cycling stability,is one of the toughest challenges hindering the development of practical lithium sulfur batteries(LSBs).Introducing catalytic nanostructures to stabilize the otherwise soluble polysulfides and promote their conversion to solids has been proved to be an effective strategy in attacking this problem,but the heavy mass of catalysts often results in a low specific energy of the whole electrode.Herein,by designing and synthesizing a free-standing edge-oriented NiCo_(2)S_(4)/vertical graphene functionalized carbon nanofiber(NCS/EOG/CNF)thin film as a catalytic overlayer incorporated in the sulfur cathode,the polysulfide shuttle effect is largely alleviated,revealed by the enhanced electrochemical performance measurements and the catalytic function demonstration.Different from other reports,the NiCo_(2)S_(4)nanosheets synthesized here have a 3-D edge-oriented structure with fully exposed edges and easily accessible in-plane surfaces,thus providing a high density of active sites even with a small mass.The EOG/CNF scaffold further renders the high conductivity in the catalytic structure.Combined,this novel structure,with high sulfur loading and high sulfur fraction,leads to high-performance sulfur cathodes toward a practical LSB technology.展开更多
With the large scale adoption of Internet of Things(IoT)applications in people’s lives and industrial manufacturing processes,IoT security has become an important problem today.IoT security significantly relies on th...With the large scale adoption of Internet of Things(IoT)applications in people’s lives and industrial manufacturing processes,IoT security has become an important problem today.IoT security significantly relies on the security of the underlying hardware chip,which often contains critical information,such as encryption key.To understand existing IoT chip security,this study analyzes the security of an IoT security chip that has obtained an Arm Platform Security Architecture(PSA)Level 2 certification.Our analysis shows that the chip leaks part of the encryption key and presents a considerable security risk.Specifically,we use commodity equipment to collect electromagnetic traces of the chip.Using a statistical T-test,we find that the target chip has physical leakage during the AES encryption process.We further use correlation analysis to locate the detailed encryption interval in the collected electromagnetic trace for the Advanced Encryption Standard(AES)encryption operation.On the basis of the intermediate value correlation analysis,we recover half of the 16-byte AES encryption key.We repeat the process for three different tests;in all the tests,we obtain the same result,and we recover around 8 bytes of the 16-byte AES encryption key.Therefore,experimental results indicate that despite the Arm PSA Level 2 certification,the target security chip still suffers from physical leakage.Upper layer application developers should impose strong security mechanisms in addition to those of the chip itself to ensure IoT application security.展开更多
基金the funding support from the National Natural Science Foundation of China(T2325012 and 52161135104)the Program for HUST Academic Frontier Youth Team.
文摘In molecular modeling of electrical double layers(EDLs),the constant charge method(CCM)is prized for its computational efficiency but cannot maintain electrode equipotentiality like the more resourceintensive constant potential method(CPM),potentially leading to inaccuracies.In certain scenarios,CCM can yield results identical to CPM.However,there are no clear guidelines to determine when CCM is sufficient and when CPM is required.Here,we conduct a series of molecular simulations across various electrodes and electrolytes to present a comprehensive comparison between CCM and CPM under different charging modes.Results reveal that CCM approximates CPM effectively in capturing equilibrium EDL and current-driven dynamics in open electrode systems featuring ionic liquids or regular concentration aqueous electrolytes,while CPM is indispensable in scenarios involving organic and highly concentrated aqueous electrolytes,nanoconfinement effects,and voltage-driven dynamics.This work helps to select appropriate methods for modeling EDL systems,prioritizing accuracy while considering computationalefficiency.
基金financially supported by the National Natural Science Foundation of China (Grant Nos.32101571,32002071)the Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding (Grant No.2021C02071-6)。
文摘Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch.
基金supported by National Natural Science Foundation of China(81200936,30872675,30901549)Shanghai Committee of Science and Technology (12JC1401800)2011 Shanghai Medical College Young Scientist Fund of Fudan University(11L-24)
文摘Objective: Metaplastic meningioma is a rare subtype of benign meningiomas, classified as WHO grade I with well prognosis. Here we presented our experiences on 15 cases of metaplastic meningioma, to investigate the clinicopathological features, therapies and prognosis of these cases. Methods: 15 patients underwent surgical treatment for intracranial metaplastic meningioma between 2001 and 2010 at Neurosurgery Department of Huashan Hospital, Shanghai, China. The clinical data, radiological manifestation, treatment strategy, pathological findings and prognosis of all patients were analyzed retrospectively. Results: Among the 15 cases (10 males and 5 females), the age ranged from 22 to 74 years old (the mean age was 50.67-year old). The clinical manifestations include headache, dizziness, seizure attack, vision decrease, and weakness of bilateral lower limbs. All the patients received surgical treatment, combined with radiotherapy in some cases. In the follow-up period, recurrence occurred in 2 cases, of which 1 patient died of other system complications. Conclusions: Metaplastic meningiomas are characterized by focal or widespread mesenchymal differentiation with formation of bone, cartilage, fat, and xanthomatous tissue elements. Surgical removal is the optimal therapy, and the overall prognosis is well. But recurrence may occur in some cases, thus radiotherapy is necessary for such kind of patients.
基金Industrial Technology Development Program(JCKY2016204A502).
文摘Background To solve the problem of visualization in augmented reality(AR),for assembly process information,we report here on our study into the composition of AR assembly process information.Methods Our work led us to classify the visual elements of assembly processes into six categories,and after looking further into visual element expression characteristics used in assembly process information in the AR environment,standard assembly process elements have been identified and visual element layout principles studied.Conclusion Typical visualization elements have been presented,using an AR-based assembly instruction system.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12074150,12174157,12174158,and 11874314)the Innovation and Entrepreneurship Talent Project of Jiangsu Province of China+1 种基金the Scientific Research Startup of Jiangsu University(Grant No.5501710001)the College Students’Innovation Training Program of Jiangsu Province of China(Grant No.202110299123Y)。
文摘Inspired by the successful synthesis of h Hv-graphane[Nano Lett.15903(2015)],a new two-dimensional(2D)Janus material Cu-graphane is proposed based on the first-principles calculations.Without the spin-orbit coupling(SOC)effect,Cu-graphane is a Dirac semimetal with a highly anisotropic Dirac cone,whose Fermi velocity ranges from 0.12×10^(5)m/s to2.9×10^(5)m/s.The Dirac cone near the Fermi level can be well described with an extended 2D Dirac model Hamiltonian.In the presence of the SOC effect,band splitting is observed around the Fermi level,and a large intrinsic spin Hall conductivity(ISHC)with a maximum value of 346(h/e)S/cm is predicted.Moreover,the spin Hall transport can be regulated by slightly adjusting the Fermi energy,e.g.,grid voltage or chemical doping.Our work not only proposes a new 2D Janus material with a highly anisotropic Dirac cone and a large ISHC,but also reveals that a large ISHC may exist in some Dirac systems.
文摘In the past 2 decades,endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia(BPH),with comparable outcomes to traditional surgeries.Transurethral vapor enucleation and resection of the prostate(TVERP),transurethral vapor enucleation of the prostate(TVEP),and ultrasound-navigated TVEP(US-TVEP)are new,innovative endoscopic enucleation procedures.These procedures are named Xie’s Prostate Enucleations(Xie’s Procedures for short).Current clinical data indicate that Xie’s Procedures are safe and effective treatment options for patients with BPH,especially for patients with larger prostates.Further prospective,randomized clinical trials compared with traditional transurethral resection of prostate(TURP)are still needed.
文摘Objective:Pancreatic ductal adenocarcinoma(PDAC)is a deadly malignancy,due in large part to its resistance to conventional therapies,including radiotherapy(RT).Despite RT exerting a modest antitumor response,it has also been shown to promote an immunosuppressive tumor microenvironment.Previous studies demonstrated that focal adhesion kinase inhibitors(FAKi)in clinical development inhibit the infiltration of suppressive myeloid cells and T regulatory(T regs)cells,and subsequently enhance effector T cell infiltration.FAK inhibitors in clinical development have not been investigated in combination with RT in preclinical murine models or clinical studies.Thus,we investigated the impact of FAK inhibition on RT,its potential as an RT sensitizer and immunomodulator in a murine model of PDAC.Methods:We used a syngeneic orthotopic murine model to study the effect of FAKi on hypofractionated RT.Results:In this study we showed that IN10018,a small molecular FAKi,enhanced antitumor response to RT.Antitumor activity of the combination of FAKi and RT is T cell dependent.FAKi in combination with RT enhanced CD8+T cell infiltration significantly in comparison to the radiation or FAKi treatment alone(P<0.05).FAKi in combination with radiation inhibited the infiltration of granulocytes but enhanced the infiltration of macrophages and T regs in comparison with the radiation or FAKi treatment alone(P<0.01).Conclusions:These results support the clinical development of FAKi as a radiosensitizer for PDAC and combining FAKi with RT to prime the tumor microenvironment of PDAC for immunotherapy.
基金supported by the National Natural Science Foundation of China (No.50704004)
文摘Vaporization behavior (1163-1463 K) of lead in the slag system of FeO-CaO-SiO2-Al2O3 with CaC% was examined. A thermodynamic estimation with the principle of Gibbs free energy minimization showed that the major vapor species from the sample of the FeO-CaO-SiO2-Al2O3 system+PbO+CaCl2 were metallic Pb, PbCl, PbCl2, and FeCl2, at the experimental temperature range. The experimental results show that the mole ratio of vaporized Cl in lead chlorides to vaporized Pb, simply expressed as Cl/Pb decreases with increasing temperature. The larger Cl/Pb means a larger ratio of gaseous PbCl2, since metallic Pb and PbCl vapors are formed in a similar reduction atmosphere. The evaporation is initially rapid and becomes steady after holding for 10 min. Gaseous PbCl2 is mainly formed during the heating period, and at the holding stage, it reacts with FeO to produce gaseous FeCl2 With regard to slag composition, FeO content and basicity significantly affect the evaporation of lead. High FeO content and high basicity promotes the formation of metallic Pb and PbCI, whereas, it prohibits PbCl2 evaporation.
基金financially supported by the National Natural Science Foundation of China (No. 52102100)the Industry-University-Research Cooperation Project of Jiangsu Province, China (No. BY2021525)the Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (No. SJCX22_1944)
文摘To improve the efficiency of cathodic oxygen reduction reaction(ORR)in zinc-air batteries(ZABs),an adsorption-complexation-calcination method was proposed to generate cobalt-based multicomponent nanoparticles comprising Co,Co_(3)O_(4)and CoN,as well as numerous N heteroatoms,on graphene nanosheets(Co/Co_(3)O_(4)/CoN/NG).The Co/Co_(3)O_(4)/CoN nanoparticles with the size of less than 50 nm are homogeneously dispersed on N-doped graphene(NG)substrate,which greatly improve the catalytic behaviors for ORR.The results show that the half-wave potential is as high as 0.80 V vs.RHE and the limiting current density is 4.60 mA·cm^(−2),which are close to those of commercially available platinum/carbon(Pt/C)catalysts.Applying as cathodic catalyst for ZABs,the battery shows large specific capacity and open circuit voltage of 843.0 mAh∙g^(−1) and 1.41 V,respectively.The excellent performance is attributed to the efficient two-dimensional structure with high accessible surface area and the numerous multiple active sites provided by highly scattered Co/Co_(3)O_(4)/CoN particles and doped nitrogen on the carbon matrix.
文摘In order to develop super-board and super-thick slabs, the flow and temperatur fields were studied in slab continuous casting molds under different practical conditions, such as slab dimensions, with-drawing slab speed, design of nozzles, and superheat tempera-ture. The results showed that it is preferred to incline nozzle bores downwards and the submerged depth of the nozzles is best kept be-tween 250-300 mm. In addition, the solidified shell is thicker at the wide face than that at the narrow face, while the thin points alongthe wide face ekist both in the center and in the some area toward each respective end.
基金supported by the National Natural Science Foundation of China(82071700,82101679,and 32288101)The University Synergy Innovation Program of Anhui Province in China(GXXT-2021-071).
文摘Globally,infertility is a serious health problem affecting about 15%of reproductive age couples according to the data reported by the World Health Organization.Non-obstructive azoospermia(NOA)is acknowledged as one of the most serious phenotypes of male infertility.Approximately 1%of the male population and 10%of infertile men were affected by NOA(Xie et al.,2022).As reported,meiotic arrest is one of the major etiologies leading to the NOA.
基金supported by the National Natural Sciences Foundation of China (81330048, 81301959, 81520108025)
文摘The survival of patients with hematological malignancies has been significantly improved due to the development of new therapeutic agents. However, relapse remains a major matter for concern. Recently, T cells engineered with chimeric antigen receptor(CAR) were reported to show unprecedented responses in a range of hematological malignancies. The persistence of the CAR-T cell can last for years and tends toward long-term antitumor memory by which relapses can be effectively prevented. The primary side effects that appear in most clinical trials are cytokine release syndrome and neurotoxicity. However, these symptoms can be treated and reversed. In this review, we describe CAR structure and function and summarize recent advances in CAR-T cell therapy in hematological malignancies.
基金the National Natural Science Foundation of China(No.31772337)the Lishui Research Fund(No.2020zdhz03)+1 种基金the China Postdoctoral Science Foundation(No.2017M612005)the National Key Research and Development Program of China(No.2018YFD1000401)。
文摘Starch is the predominant compound in bulb scales,and previous studies have shown that bulblet development is closely associated with starch enrichment.However,how starch synthesis affects bulbification at the molecular level is unclear.In this study,we demonstrate that Lilium brownii var.giganteum,a wild lily with a giant bulb in nature,and L.brownii,the native species,have different starch levels and characteristics according to cytological and ultra-structural observations.We cloned the complete sequence of three key gene-encoding enzymes(LbgAGPS,LbgGBSS,and LbgSSⅢ)during starch synthesis by rapid amplification of 5’and 3’complementary DNA(cDNA)ends(RACE)technology.Bioinformatics analysis revealed that the proteins deduced by these genes contain the canonical conserved domains.Constructed phylogenetic trees confirmed the evolutionary relationships with proteins from other species,including monocotyledons and dicotyledons.The transcript levels of various tissues and time course samples obtained during bulblet development uncovered relatively high expression levels in bulblets and gradual increase expression accompanying bulblet growth.Moreover,a set of single nucleotide polymorphisms(SNPs)was discovered in the AGPS genes of four lily genotypes,and a purifying selection fashion was predicted according to the non-synonymous/synonymous(Ka/Ks)values.Taken together,our results suggested that key starch-synthesizing genes might play important roles in bulblet development and lead to distinctive phenotypes in bulblet size.
基金the National Science Foundation of USA(1931737).
文摘Polysulfide shuttle effect,causing extremely low Coulombic efficiency and cycling stability,is one of the toughest challenges hindering the development of practical lithium sulfur batteries(LSBs).Introducing catalytic nanostructures to stabilize the otherwise soluble polysulfides and promote their conversion to solids has been proved to be an effective strategy in attacking this problem,but the heavy mass of catalysts often results in a low specific energy of the whole electrode.Herein,by designing and synthesizing a free-standing edge-oriented NiCo_(2)S_(4)/vertical graphene functionalized carbon nanofiber(NCS/EOG/CNF)thin film as a catalytic overlayer incorporated in the sulfur cathode,the polysulfide shuttle effect is largely alleviated,revealed by the enhanced electrochemical performance measurements and the catalytic function demonstration.Different from other reports,the NiCo_(2)S_(4)nanosheets synthesized here have a 3-D edge-oriented structure with fully exposed edges and easily accessible in-plane surfaces,thus providing a high density of active sites even with a small mass.The EOG/CNF scaffold further renders the high conductivity in the catalytic structure.Combined,this novel structure,with high sulfur loading and high sulfur fraction,leads to high-performance sulfur cathodes toward a practical LSB technology.
基金This work was partially supported by the National Natural Science Foundation of China(Nos.61872243 and U1713212)Guangdong Basic and Applied Basic Research Foundation(No.2020A1515011489)+1 种基金the Natural Science Foundation of Guangdong Province-Outstanding Youth Program(No.2019B151502018)Shenzhen Science and Technology Innovation Commission(No.R2020A045).
文摘With the large scale adoption of Internet of Things(IoT)applications in people’s lives and industrial manufacturing processes,IoT security has become an important problem today.IoT security significantly relies on the security of the underlying hardware chip,which often contains critical information,such as encryption key.To understand existing IoT chip security,this study analyzes the security of an IoT security chip that has obtained an Arm Platform Security Architecture(PSA)Level 2 certification.Our analysis shows that the chip leaks part of the encryption key and presents a considerable security risk.Specifically,we use commodity equipment to collect electromagnetic traces of the chip.Using a statistical T-test,we find that the target chip has physical leakage during the AES encryption process.We further use correlation analysis to locate the detailed encryption interval in the collected electromagnetic trace for the Advanced Encryption Standard(AES)encryption operation.On the basis of the intermediate value correlation analysis,we recover half of the 16-byte AES encryption key.We repeat the process for three different tests;in all the tests,we obtain the same result,and we recover around 8 bytes of the 16-byte AES encryption key.Therefore,experimental results indicate that despite the Arm PSA Level 2 certification,the target security chip still suffers from physical leakage.Upper layer application developers should impose strong security mechanisms in addition to those of the chip itself to ensure IoT application security.