A simple metal and additive-free approach for the assembly of 5-trifluoromethyl-1,2,4-triazoles via only heatinginduced decarboxylative cyclization of readily available trifluoroacetimidohydrazides andα-oxocarboxylic...A simple metal and additive-free approach for the assembly of 5-trifluoromethyl-1,2,4-triazoles via only heatinginduced decarboxylative cyclization of readily available trifluoroacetimidohydrazides andα-oxocarboxylic acids has been developed.In this protocol,the rarely reported tetrahedral carboxylic acids intermediate could be in-situ generated and undergo subsequent decarboxylation to afford the target heterocycle products.展开更多
基金support from the Natural Science Foundation of Zhejiang Province(No.LY19B020016)the K.C.Wong Education Foundation(No.GJTD-2020-08).
文摘A simple metal and additive-free approach for the assembly of 5-trifluoromethyl-1,2,4-triazoles via only heatinginduced decarboxylative cyclization of readily available trifluoroacetimidohydrazides andα-oxocarboxylic acids has been developed.In this protocol,the rarely reported tetrahedral carboxylic acids intermediate could be in-situ generated and undergo subsequent decarboxylation to afford the target heterocycle products.
