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病原体逃逸宿主固有免疫的新策略:抑制细胞焦亡 被引量:1
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作者 杨茂艺 崔潇月 +3 位作者 郑诗棋 马诗瑶 郑增长 邓万燕 《遗传》 CAS CSCD 北大核心 2023年第11期986-997,共12页
细胞焦亡是一种由Gasdermin家族蛋白介导的新型程序性细胞死亡。当宿主细胞感应病原体感染或其他危险信号时,Gasdermin家族蛋白被切割活化并诱导细胞焦亡。细胞焦亡过程往往伴随大量炎性细胞因子释放,这些炎性细胞因子在宿主清除病原体... 细胞焦亡是一种由Gasdermin家族蛋白介导的新型程序性细胞死亡。当宿主细胞感应病原体感染或其他危险信号时,Gasdermin家族蛋白被切割活化并诱导细胞焦亡。细胞焦亡过程往往伴随大量炎性细胞因子释放,这些炎性细胞因子在宿主清除病原体过程中发挥着至关重要作用,而病原体在与宿主长期“博弈”过程中也进化出抑制细胞焦亡的策略以实现免疫逃逸。本文介绍了细胞焦亡的发现历程及其在抗感染免疫中的重要功能,并总结了病原体抑制细胞焦亡的多种新策略及其相关研究进展。深入理解细胞焦亡的发生及调控机制,可揭示相关感染性疾病的发病机制并有助于开发有效的抗感染治疗策略。 展开更多
关键词 细胞焦亡 病原体 效应蛋白 免疫逃逸
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Periodic event-triggered secure consensus for networked mechanical systems under Denial-of-Service attacks
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作者 shiqi zheng Zhipeng Li +1 位作者 Chao Zhai Peng Shi 《Control Theory and Technology》 EI CSCD 2024年第1期1-13,共13页
This paper concentrates on the secure consensus problem of networked mechanical/Euler–Lagrange systems.First,a new periodic event-triggered(PET)secure distributed observer is proposed to estimate the leader informati... This paper concentrates on the secure consensus problem of networked mechanical/Euler–Lagrange systems.First,a new periodic event-triggered(PET)secure distributed observer is proposed to estimate the leader information.The proposed distributed observer only relies on the PET data from its neighbors,which can significantly reduce the communication and computational burden.More importantly,it is secure in the sense that it can work normally regardless of the Denial-of-Service(DoS)attacks.Second,based on the proposed distributed observer,an adaptive fuzzy control law is proposed for each Euler–Lagrange system.A PET mechanism is integrated into the controller,which can reduce the control update.This is helpful for both energy saving and fault tolerance of actuators.Moreover,the PET mechanism naturally makes the controller easy to be implemented in digital platform.The property of fuzzy logic systems and Gronwall inequality are skillfully utilized to show the stability of the closed-loop system.Finally,the proposed control scheme is verified on real Euler–Lagrange systems,which contain a robot manipulator and several servo motors. 展开更多
关键词 Output regulation Mechanical/Euler-Lagrange systems Periodic event-triggered mechanism Denial-of-Service attacks
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Obstacle-circumventing adaptive control of a four-wheeled mobile robot subjected to motion uncertainties
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作者 Yiming YAN Shuting WANG +3 位作者 Yuanlong XIE Hao WU shiqi zheng Hu LI 《Frontiers of Mechanical Engineering》 SCIE CSCD 2023年第3期123-143,共21页
To achieve the collision-free trajectory tracking of the four-wheeled mobile robot(FMR),existing methods resolve the tracking control and obstacle avoidance separately.Guaranteeing the synergistic robustness and smoot... To achieve the collision-free trajectory tracking of the four-wheeled mobile robot(FMR),existing methods resolve the tracking control and obstacle avoidance separately.Guaranteeing the synergistic robustness and smooth navigation of mobile robots subjected to motion uncertainties in a dynamic environment using this non-cooperative processing method is difficult.To address this challenge,this paper proposes an obstacle-circumventing adaptive control(OCAC)framework.Specifically,a novel anti-disturbance terminal slide mode control with adaptive gains is formulated,incorporating specified control laws for different stages.This formulation guarantees rapid convergence and simultaneous chattering elimination.By introducing sub-target points,a new sub-target dynamic tracking regression obstacle avoidance strategy is presented to transfer the obstacle avoidance problem into a dynamic tracking one,thereby reducing the burden of local path searching while ensuring system stability during obstacle circumvention.Comparative experiments demonstrate that the proposed OCAC method can strengthen the convergence and obstacle avoidance efficiency of the concerned FMR system. 展开更多
关键词 four-wheeled mobile robot obstacle-circumventing adaptive control adaptive anti-disturbance terminal sliding mode control sub-target dynamic tracking regression obstacle avoidance
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