Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary an...Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary and secondary injuries.Hematoma,as the primary pathology of ICH,undergoes metabolism and triggers biochemical and biomechanical alterations in the brain,leading to the secondary injury.Past endeavors mainly aimed at biochemical-initiated mechanisms for causing secondary injury,which have made limited progress in recent years,although ICH itself is also highly biomechanics-related.The discovery of the mechanically-activated cation channel Piezo1 provides a new avenue to further explore the mechanisms underlying the secondary injury.The current article reviews the structure and gating mechanisms of Piezo1,its roles in the physiology/pathophysiology of neurons,astrocytes,microglia,and bone-marrow-derived macrophages,and especially its roles in erythrocytic turnover and iron metabolism,revealing a potential interplay between the biomechanics and biochemistry of hematoma in ICH.Collectively,these advances provide deeper insights into the secondary injury of ICH and lay the foundations for future research.展开更多
The rubber industry in Shanwei Reclamation Area has grown into a leading industry in the reclamation area,but there are some problems in rubber plantations such as wind damage,neglect of supporting construction for sh...The rubber industry in Shanwei Reclamation Area has grown into a leading industry in the reclamation area,but there are some problems in rubber plantations such as wind damage,neglect of supporting construction for shelter forest in the planting plan,and lack of rubber tappers. For the sustainable development of rubber farming,it is necessary to select the appropriate plot to plant rubber based on the habitat requirements of rubber trees; plan the supporting construction shelter forest network in cultivation of rubber trees; build organic rubber plantations,produce high-quality natural rubber and increase the output value of rubber plantations; use new tapping system to reduce tapping labor,improve tapping benefits and increase income of rubber tappers.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.82271426).
文摘Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary and secondary injuries.Hematoma,as the primary pathology of ICH,undergoes metabolism and triggers biochemical and biomechanical alterations in the brain,leading to the secondary injury.Past endeavors mainly aimed at biochemical-initiated mechanisms for causing secondary injury,which have made limited progress in recent years,although ICH itself is also highly biomechanics-related.The discovery of the mechanically-activated cation channel Piezo1 provides a new avenue to further explore the mechanisms underlying the secondary injury.The current article reviews the structure and gating mechanisms of Piezo1,its roles in the physiology/pathophysiology of neurons,astrocytes,microglia,and bone-marrow-derived macrophages,and especially its roles in erythrocytic turnover and iron metabolism,revealing a potential interplay between the biomechanics and biochemistry of hematoma in ICH.Collectively,these advances provide deeper insights into the secondary injury of ICH and lay the foundations for future research.
基金Supported by Special Funds for Fundamental Research in Chinese Academy of Tropical Agricultural Sciences"Study on the Adjustment and Development of Main Tropical Crops in the Supply Side Context".(1630072016013)
文摘The rubber industry in Shanwei Reclamation Area has grown into a leading industry in the reclamation area,but there are some problems in rubber plantations such as wind damage,neglect of supporting construction for shelter forest in the planting plan,and lack of rubber tappers. For the sustainable development of rubber farming,it is necessary to select the appropriate plot to plant rubber based on the habitat requirements of rubber trees; plan the supporting construction shelter forest network in cultivation of rubber trees; build organic rubber plantations,produce high-quality natural rubber and increase the output value of rubber plantations; use new tapping system to reduce tapping labor,improve tapping benefits and increase income of rubber tappers.
