The importance of genetic factors in substance addiction has long been established.The rationale for this work is that understanding of the function of addiction genes and delineation of the key molecular pathways of ...The importance of genetic factors in substance addiction has long been established.The rationale for this work is that understanding of the function of addiction genes and delineation of the key molecular pathways of these genes would enhance the development of novel therapeutic targets and biomarkers that could be used in the prevention and management of substance abuse.Over the past few years,there has been a substantial increase in the number of genetic studies conducted on addiction in China;these studies have primarily focused on heroin,alcohol,and nicotine dependence.Most studies of candidate genes have concentrated on the dopamine,opioid,and serotonin systems.A number of genes associated with substance abuse in Caucasians are also risk factors in Chinese,but several novel genes and genetic risk factors associated with substance abuse in Chinese subjects have also been identified.This paper reviews the genetic studies of substance abuse performed by Chinese researchers.Genotypes and alleles related to addictive behavior in Chinese individuals are discussed and the contributions of Chinese researchers to the international corpus of knowledge about the genetic understanding of substance abuse are described.展开更多
With the advent of improved tools to examine the astrocytes,which have been believed to play a supportive role in the central nervous system(CNS)for years,their participation in the operation of the CNS and drug addic...With the advent of improved tools to examine the astrocytes,which have been believed to play a supportive role in the central nervous system(CNS)for years,their participation in the operation of the CNS and drug addiction was unveiled.Assisting the formation and function of the CNS,astrocytes are involved in physiological and pathological brain activities.Drug addiction is a pervasive psychiatric disorder,characterized by compulsive drug-taking behavior and high rate of relapse,impacting individual health and society stability and safety.When exposed to drugs of abuse,astrocytes go through a series of alterations,contributing to the development of addiction.Here we review how astrocytes contribute to the CNS and drug addiction.We hope that understanding the interaction between addictive drugs and astrocytes may help discover new mechanisms underlying the addiction and produce novel therapeutic treatments.展开更多
基金provided by the National Research Program of China(No.2009CB522007)the Natural Science Foundation of China(No.91132719)
文摘The importance of genetic factors in substance addiction has long been established.The rationale for this work is that understanding of the function of addiction genes and delineation of the key molecular pathways of these genes would enhance the development of novel therapeutic targets and biomarkers that could be used in the prevention and management of substance abuse.Over the past few years,there has been a substantial increase in the number of genetic studies conducted on addiction in China;these studies have primarily focused on heroin,alcohol,and nicotine dependence.Most studies of candidate genes have concentrated on the dopamine,opioid,and serotonin systems.A number of genes associated with substance abuse in Caucasians are also risk factors in Chinese,but several novel genes and genetic risk factors associated with substance abuse in Chinese subjects have also been identified.This paper reviews the genetic studies of substance abuse performed by Chinese researchers.Genotypes and alleles related to addictive behavior in Chinese individuals are discussed and the contributions of Chinese researchers to the international corpus of knowledge about the genetic understanding of substance abuse are described.
基金funded by the Ministry of Science and Technology of China(2021ZD0202100,2021ZD0201900)National Natural Science Foundation of China(U1802283,82130040,81901352)Beijing Municipal Science&Technology Commission(Z181100001518005).
文摘With the advent of improved tools to examine the astrocytes,which have been believed to play a supportive role in the central nervous system(CNS)for years,their participation in the operation of the CNS and drug addiction was unveiled.Assisting the formation and function of the CNS,astrocytes are involved in physiological and pathological brain activities.Drug addiction is a pervasive psychiatric disorder,characterized by compulsive drug-taking behavior and high rate of relapse,impacting individual health and society stability and safety.When exposed to drugs of abuse,astrocytes go through a series of alterations,contributing to the development of addiction.Here we review how astrocytes contribute to the CNS and drug addiction.We hope that understanding the interaction between addictive drugs and astrocytes may help discover new mechanisms underlying the addiction and produce novel therapeutic treatments.
