Research shows that the mortality rate among people with schizophrenia is up to four times higher than that in the general population. The subsequent high comorbidities and societal cost of schizophrenia necessitate f...Research shows that the mortality rate among people with schizophrenia is up to four times higher than that in the general population. The subsequent high comorbidities and societal cost of schizophrenia necessitate finding better,more effective treatments and strategies for prevention. One of the current obstacles are the complicated gene etiologies that are involved in the pathophyslology of schizophrenia. So far, an increasing number of clinical and experimental studies show links between schizophrenia treatment and genetic conditions. Here, we analyze the literature on schizophrenia genetics, with a particular focus on the brain, the mind and environmental insults. An overlap of schlzophrenla with other psychotic disorders has also been taken into accunt with an attempt to find a parallel relationship between genetics and treatment. Finally, we summarize all the present-day treatment options for schizophrenia like clozapine and electroconvulslve therapy and also take into consideration the relatively unexplored role of traditional Chinese medicine.展开更多
This article highlights the fact that anorexia and bulimia nervosa aren't simply psychiatric disturbances, but recent identification of genetic linkages show that they are also physical disease, with higher incide...This article highlights the fact that anorexia and bulimia nervosa aren't simply psychiatric disturbances, but recent identification of genetic linkages show that they are also physical disease, with higher incidences seen in children who have a parent with an eating disorder. Even having a relative with an eating disorder has become a predisposing factor. However, more research still needs to be carried out on this to establish clear patterns of inheritance. This paper also touches on the greater impact that eating disorders have on society as a whole. Past studies undertaken primarily in female patients have reflected a gradual increase in mortality rates which have been significant enough to be of epidemiological and statistical importance. We then focused on some new treatment approaches and observe an universal pattern of improvement among patients who were also treated with music therapy as compared to standard traditional treatment measures. Finally, we summarized the importance of awareness and education among young adults in preventing mental health disorders and eliminating the stigma around seeking therapy.展开更多
This review aims to summarize how Tau pathology, in particular, brings about Alzheimer’s disease (AD). Various studies from the past decade have been analyzed with the purpose of providing a compact descrip-tion on h...This review aims to summarize how Tau pathology, in particular, brings about Alzheimer’s disease (AD). Various studies from the past decade have been analyzed with the purpose of providing a compact descrip-tion on how Tau protein infl uences AD. The pathologies associated with the accumulation of Amyloid and Tau have always been at the forefront of all research on Alzheimer’s disease, which have usually centered around a deeper understanding of the pathophysiological mechanisms, or on developing therapeutics targeting these proteins. Recent data has also continuously been challenging the ubiquitous acceptance of amyloid being the driving force for Alzheimer’s disease as anamyloid therapies continue to fail. Tau protein shows an independent ability to accumulate within nerve cells, and its propagation shows a continuous seeding and spreading patiern. The purpose of this review is thus to enforce the importance of Tau pathology and tailor future developments in AD treatment accordingly. By the end of this review, we thus infer how regional accumulations of Tau aff ect AD, how and why the amyloid cascade hypothesis needs to change, and we end by looking at fi ndings from the recent “Beyond Amyloid” symposium where factors like a loss in DNA integrity, cell cycle disorders and microtubular dysregulation have been proposed as potential mediators of AD.展开更多
文摘Research shows that the mortality rate among people with schizophrenia is up to four times higher than that in the general population. The subsequent high comorbidities and societal cost of schizophrenia necessitate finding better,more effective treatments and strategies for prevention. One of the current obstacles are the complicated gene etiologies that are involved in the pathophyslology of schizophrenia. So far, an increasing number of clinical and experimental studies show links between schizophrenia treatment and genetic conditions. Here, we analyze the literature on schizophrenia genetics, with a particular focus on the brain, the mind and environmental insults. An overlap of schlzophrenla with other psychotic disorders has also been taken into accunt with an attempt to find a parallel relationship between genetics and treatment. Finally, we summarize all the present-day treatment options for schizophrenia like clozapine and electroconvulslve therapy and also take into consideration the relatively unexplored role of traditional Chinese medicine.
文摘This article highlights the fact that anorexia and bulimia nervosa aren't simply psychiatric disturbances, but recent identification of genetic linkages show that they are also physical disease, with higher incidences seen in children who have a parent with an eating disorder. Even having a relative with an eating disorder has become a predisposing factor. However, more research still needs to be carried out on this to establish clear patterns of inheritance. This paper also touches on the greater impact that eating disorders have on society as a whole. Past studies undertaken primarily in female patients have reflected a gradual increase in mortality rates which have been significant enough to be of epidemiological and statistical importance. We then focused on some new treatment approaches and observe an universal pattern of improvement among patients who were also treated with music therapy as compared to standard traditional treatment measures. Finally, we summarized the importance of awareness and education among young adults in preventing mental health disorders and eliminating the stigma around seeking therapy.
文摘This review aims to summarize how Tau pathology, in particular, brings about Alzheimer’s disease (AD). Various studies from the past decade have been analyzed with the purpose of providing a compact descrip-tion on how Tau protein infl uences AD. The pathologies associated with the accumulation of Amyloid and Tau have always been at the forefront of all research on Alzheimer’s disease, which have usually centered around a deeper understanding of the pathophysiological mechanisms, or on developing therapeutics targeting these proteins. Recent data has also continuously been challenging the ubiquitous acceptance of amyloid being the driving force for Alzheimer’s disease as anamyloid therapies continue to fail. Tau protein shows an independent ability to accumulate within nerve cells, and its propagation shows a continuous seeding and spreading patiern. The purpose of this review is thus to enforce the importance of Tau pathology and tailor future developments in AD treatment accordingly. By the end of this review, we thus infer how regional accumulations of Tau aff ect AD, how and why the amyloid cascade hypothesis needs to change, and we end by looking at fi ndings from the recent “Beyond Amyloid” symposium where factors like a loss in DNA integrity, cell cycle disorders and microtubular dysregulation have been proposed as potential mediators of AD.
