The present work deals with preliminary in-vitro studies to validate the traditional claims of medicinal properties in consuming Curcuma flowers to make the person less susceptible to diseases and the estimation of bi...The present work deals with preliminary in-vitro studies to validate the traditional claims of medicinal properties in consuming Curcuma flowers to make the person less susceptible to diseases and the estimation of bioactive compounds responsible for antioxidant activity present. The anti-proliferative activity of aqueous extracts of budding flowers, leaves, full bloomed flowers and mixture of all parts of Curcuma angustifolia was studied using MDCK, Vero and HeLa cell lines. The inhibitory activity in all the three cell lines was found to be dose dependent. The extract of leaves and budding flowers exhibited higher inhibitions in MDCK and Vero cells while the full bloomed flowers extract showed higher inhibitory activities in HeLa cells. The bioactive compounds--total phenolics content ranged from 56.96 mg GAE/100 gm to 86.77 mg GAE/100 gm which was highest in full bloomed flowers, total flavonoids and the free radical scavenging activity content ranged from 84.74 mg CE/100 g to 166.11 mg CE/100 g and 43.91 mg to 64.02 mg AEAC/100 gm respectively, with maximum content in budding flowers. The result showed potential anti-proliferative and antioxidant properties that substantiate the belief of the indigenous people to include the plant in their dietary habits which could be exploited for use in preparation of herbal drugs and supplements.展开更多
文摘The present work deals with preliminary in-vitro studies to validate the traditional claims of medicinal properties in consuming Curcuma flowers to make the person less susceptible to diseases and the estimation of bioactive compounds responsible for antioxidant activity present. The anti-proliferative activity of aqueous extracts of budding flowers, leaves, full bloomed flowers and mixture of all parts of Curcuma angustifolia was studied using MDCK, Vero and HeLa cell lines. The inhibitory activity in all the three cell lines was found to be dose dependent. The extract of leaves and budding flowers exhibited higher inhibitions in MDCK and Vero cells while the full bloomed flowers extract showed higher inhibitory activities in HeLa cells. The bioactive compounds--total phenolics content ranged from 56.96 mg GAE/100 gm to 86.77 mg GAE/100 gm which was highest in full bloomed flowers, total flavonoids and the free radical scavenging activity content ranged from 84.74 mg CE/100 g to 166.11 mg CE/100 g and 43.91 mg to 64.02 mg AEAC/100 gm respectively, with maximum content in budding flowers. The result showed potential anti-proliferative and antioxidant properties that substantiate the belief of the indigenous people to include the plant in their dietary habits which could be exploited for use in preparation of herbal drugs and supplements.
