Systematic Review and Meta-analysis of Efficacy of Banxia Xiexin Decoction for Treatment of Bile Reflux Gastritis

[Objectives]The purpose was to study the clinical efficacy and safety of Banxia Xiexin decoction in treating bile reflux gastritis(BRG).[Methods]Randomized controlled trial was adopted to conduct scientific and standardized assessment on the risk of bias in the included articles.With overall effect and epigastric pain relief as indices,meta-analysis was performed,and sensitivity and safety analysis was conducted on the included literature.[Results]A total of 13 articles were included,involving a total of 1478 patients.The results of meta-analysis show that the efficacy of Banxia Xiexin decoction alone and Banxia Xiexin decoction-Western medicine combination is better than that of Western medicine alone.[Conclusions]Banxia Xiexin decoction is safe and effective in treating bile reflux gastritis.However,as the 13 articles included are all low in quality and there is a certain degree of publication bias,the objectivity of the results is affected to some extent.

Systematic Review and Meta-analysis of Tanshinone Capsule in the Treatment of Polycystic Ovary Syndrome

[Objectives]To study the efficacy and safety of tanshinone capsule in the treatment of polycystic ovary syndrome(PCOS).[Methods]A randomized controlled trial or semi-randomized controlled trial of tanshinone capsule in the treatment of polycystic ovary syndrome was included.Two researchers screened the retrieved literature,extracted the data,assessed the risk of bias of the included literature,and then carried out meta-analysis.[Results]A total of 5 articles were included,involving 350 patients.The results of meta-analysis showed that compared with the control group,tanshinone capsule could reduce total cholesterol[MD=-0.73,95%CI(-0.86,-0.60),P<0.00001],triglyceride[MD=-0.40,95%CI(-0.57,-0.23),P<0.00001],low density lipoprotein cholesterol[MD=-0.47,95%CI(-0.73,-0.53),P<0.00001],follicle stimulating hormone[MD=-0.63,95%CI(-0.73,-0.53),P<0.00001],increase high density lipoprotein cholesterol[MD=0.28,95%CI(0.20,0.35),P<0.00001],the effective rate(P=0.06)and luteinizing hormone(P=0.07)in the treatment of polycystic ovary syndrome.[Conclusions]Tanshinone capsule could effectively improve the level of lipid metabolism and follicle stimulating hormone in patients with polycystic ovary syndrome.

Advances in Research of Resources and Cultivation Techniques of Chinese Medicinal Material Radix Bupleuri

At present,with the vigorous development of traditional Chinese medicines,wild Bupleurum chinense resources become increasingly depleted,and its cultivars have become the mainstream of the market.However,due to factors such as a large number of original plants,irregular planting techniques,and poor growth environment,the quality of cultivated B.chinense is uneven and it is difficult to achieve the expected efficacy.In order to protect the wild resources of B.chinense and expand the source of medicinal materials,this paper summarized the research advances of the main resource producing areas and cultivation techniques of B.chinense in combination with relevant documents published at home and abroad,and discussed the future development of B.chinense,to provide a reference for research and sustainable development of B.chinense resources.

Systematic Review and Meta-analysis of Biyuanshu Oral Liquid in the Treatment of Chronic Rhinosinusitis

[Objectives]The objective was to study the clinical efficacy and safety of Biyuanshu oral liquid in the treatment of chronic rhinosinusitis(CRS).[Methods]Randomized controlled trial was adopted to conduct scientific and standardized assessment on the risk of bias in the included papers.With overall effect and incidence of adverse reactions as indices,meta-analysis was performed,and sensitivity and safety analysis was conducted on the included literature.[Results]A total of 15 papers were included,involving 1489 patients.The efficiency of Biyuanshu oral liquid combined with Western medicine was better than that of Western medicine alone.[Conclusions]Biyuanshu oral liquid is safe and effective in treating chronic rhinosinusitis,and is suitable for patients who are not convenient for surgery.However,as the 15 papers included are all low in quality and there is a certain degree of publication bias,the objectivity of the results is affected to some extent.

Effects of Quercetin on Blood Pressure in Animals:A Systematic Review and Meta-analysis

[Objectives] To make a systematic evaluation of the efficacy and safety of quercetin on animal blood pressure.[Methods] The CNKI,Wan Fang,VIP,CBM,Pubmed,and Cochrane Library databases were searched for the literature about the effects of quercetin on blood pressure in the period from the creation of databases to April 2018.Two researchers separately screened literature and extracted data.Meta-analysis was carried out with the aid of Rev Men 5.3 software.[Results]A total of 10 articles were included,involving 288 animals.All animals were rodents.Meta-analysis results showed that there was a statistically significant difference in Systolic Blood Pressure(SBP) between the quercetin group and the control group.MD =-21.43,95% CI(-28.99,-13.86),P < 0.000 01;subgroup analysis,hypertensive animal group,MD =-29.52,95% CI(-36.05,-22.98),P < 0.000 01;the ability of quercetin group in lowering blood pressure was better than that of the control group,and the difference was statistically significant;in the normal blood pressure group,MD =-0.49,95% CI(-3.74,2.77),P = 0.77,the quercetin group was basically the same as the control group,the difference was not statistically significant.[Conclusions] Compared with the blank control group,quercetin can effectively reduce the blood pressure of hypertensive animals,but it has little effect on the blood pressure of normal animals.Besides,further study is needed on the safety of quercetin.

Systematic Evaluation and Meta-analysis of Modified Baitouweng Decoction in the Treatment of Ulcerative Colitis

[Objectives]To evaluate the clinical efficacy and safety of Modified Baitouweng Decoction in the treatment of ulcerative colitis(UC).[Methods]A randomized controlled trial of Modified Baitouweng Decoction in the treatment of ulcerative colitis was conducted,and the biased risk was evaluated in the included literature using a standardized method.A meta-analysis of the total effective rate and recurrence rate of the included literature was carried out.Sensitivity and safety analysis was carried out on the included literature.[Results]A total of 19 articles were included,involving a total of 1613 patients.The results of meta-analysis showed that the treatment of Modified Baitouweng Decoction alone or in combination with the western medicine is better than the treatment with the western medicine alone.[Conclusions]Modified Baitouweng Decoction is safe and effective in the treatment of ulcerative colitis.However,since the 19 articles included in this study are not high in quality,they have certain influence on the objectivity of the results.