Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue homeostasis.The integrity of their functions heavily relies on the generati...Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue homeostasis.The integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult myelopoiesis.In mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.展开更多
基金supported by grants from the National Natural Science Foundation of China/Research Grants Council Joint Research Scheme(31961160726)the National Key Research and Development Program of China(2018YFA0800200)+1 种基金the Major Program of Shenzhen Bay Laboratory(S201101002)the Research Grants Council of Hong Kong(RGC/NFSC N_HKUST603/19,16102022,16101621,T13-605/18-W,T13-602/21-N).
文摘Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue homeostasis.The integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult myelopoiesis.In mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.
