A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequenti...A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequential trifluoroacetylation and double carbonyl-ene reaction followed by elimination reaction.This methodology exhibits good functional group tolerance,and derivatization of the 2-trifluoromethyl chromene product resulted in other valuable scaffolds.展开更多
基金This work was supported by the National Natural Science Foundation of China(21772022),Minjiang University,and Fuzhou University.
文摘A new protocol for the synthesis of diversely substituted 2-trifluoromethyl chromenes from the cyclization reaction of o-isopropenylphenols with trifluoroacetic anhydride has been developed,which proceeds via sequential trifluoroacetylation and double carbonyl-ene reaction followed by elimination reaction.This methodology exhibits good functional group tolerance,and derivatization of the 2-trifluoromethyl chromene product resulted in other valuable scaffolds.
