目的评价静脉输注右美托咪定对甲状腺手术患者术后恢复质量的影响。方法选取2020年8月-2021年4月我院择期行甲状腺手术患者80例,按照随机数字表法分为右美托咪定组(D组)和对照组(C组),每组40例。D组于麻醉诱导前静脉输注右美托咪定负荷...目的评价静脉输注右美托咪定对甲状腺手术患者术后恢复质量的影响。方法选取2020年8月-2021年4月我院择期行甲状腺手术患者80例,按照随机数字表法分为右美托咪定组(D组)和对照组(C组),每组40例。D组于麻醉诱导前静脉输注右美托咪定负荷量1μg/kg,时间为10 min,继以0.4μg/(kg·h)的速度持续输注至手术结束前30 min;C组则输注等容量生理盐水。比较两组手术时间、麻醉时间、瑞芬太尼用量、QoR-15评分、VAS评分、术后镇痛补救和恶心呕吐发生情况。结果两组手术时间和麻醉时间比较,差异无统计学意义(P>0.05);D组瑞芬太尼用量少于C组,差异有统计学意义(P<0.05);D组术后第1天身体舒适度、情绪状态、疼痛和QoR-15总评分均高于C组,差异有统计学意义(P<0.05),两组心理支持和身体独立性评分比较,差异无统计学意义(P>0.05);D组术后2、4、8、12 h VAS评分低于C组,差异有统计学意义(P<0.05);两组术后24 h VAS评分比较,差异无统计学意义(P>0.05);D组术后第1次需要镇痛补救的时间长于C组,需要镇痛补救的人数、术后曲马多总用量以及恶心呕吐发生率低于C组,差异有统计学意义(P<0.05)。结论静脉输注右美托咪定可以改善甲状腺手术患者的术后恢复质量,提供良好的术后镇痛,降低术后恶心呕吐发生率。展开更多
Background:Hand-foot-and-mouth disease(HFMD)is a common pediatric infectious disease caused by a variety of intestinal viruses.Enterovirus 71(EV71)is the primary pathogen that might cause severe symptoms and even deat...Background:Hand-foot-and-mouth disease(HFMD)is a common pediatric infectious disease caused by a variety of intestinal viruses.Enterovirus 71(EV71)is the primary pathogen that might cause severe symptoms and even death in children with HFMD.This study aimed to investigate the intestinal detoxification time of HFMD children with EV71 infection and its related factors.Methods:Sixty-five HFMD children with EV71 infection were followed up.Their stool samples were collected once every 4 to 7 days.Viral nucleic acids were detected byfl uorescent polymerase chain reaction until the results became negative.The positive rates of viral nucleic acids were analyzed by the Kaplan-Meier method.The Log-rank test and Cox-Mantel test were used to analyze factors affecting the HFMD children with EV71 infection.Results:On the 2nd,4th,6th and 10th week,the positive rates of viral nucleic acids in stool samples of the 65 children were 94.6%,48.1%,17.2%and 0,respectively.Univariate analysis showed that the intestinal detoxification time of the children were related to gender,pre-admission disease course,severity of disease,and use of steroids or gamma globulin(P<0.05).Multivariate analysis showed that the severity of disease was an independent factor affecting the intestinal detoxification time(P<0.05),with a relative risk of 2.418.Conclusions:The longest intestinal detoxification time of HFMD children with EV71 infection was 10 weeks.The severity of disease was an important factor affecting the intestinal detoxification time of HFMD children with EV71 infection.Severe HFMD children with EV71 infection had a longer intestinal detoxification time.展开更多
文摘目的评价静脉输注右美托咪定对甲状腺手术患者术后恢复质量的影响。方法选取2020年8月-2021年4月我院择期行甲状腺手术患者80例,按照随机数字表法分为右美托咪定组(D组)和对照组(C组),每组40例。D组于麻醉诱导前静脉输注右美托咪定负荷量1μg/kg,时间为10 min,继以0.4μg/(kg·h)的速度持续输注至手术结束前30 min;C组则输注等容量生理盐水。比较两组手术时间、麻醉时间、瑞芬太尼用量、QoR-15评分、VAS评分、术后镇痛补救和恶心呕吐发生情况。结果两组手术时间和麻醉时间比较,差异无统计学意义(P>0.05);D组瑞芬太尼用量少于C组,差异有统计学意义(P<0.05);D组术后第1天身体舒适度、情绪状态、疼痛和QoR-15总评分均高于C组,差异有统计学意义(P<0.05),两组心理支持和身体独立性评分比较,差异无统计学意义(P>0.05);D组术后2、4、8、12 h VAS评分低于C组,差异有统计学意义(P<0.05);两组术后24 h VAS评分比较,差异无统计学意义(P>0.05);D组术后第1次需要镇痛补救的时间长于C组,需要镇痛补救的人数、术后曲马多总用量以及恶心呕吐发生率低于C组,差异有统计学意义(P<0.05)。结论静脉输注右美托咪定可以改善甲状腺手术患者的术后恢复质量,提供良好的术后镇痛,降低术后恶心呕吐发生率。
基金supported by grants from the Health Science and Technology Program of Hangzhou(No.2011A039)the Medical Science and Technology Program of Zhejiang Province(No.2012KYB159).
文摘Background:Hand-foot-and-mouth disease(HFMD)is a common pediatric infectious disease caused by a variety of intestinal viruses.Enterovirus 71(EV71)is the primary pathogen that might cause severe symptoms and even death in children with HFMD.This study aimed to investigate the intestinal detoxification time of HFMD children with EV71 infection and its related factors.Methods:Sixty-five HFMD children with EV71 infection were followed up.Their stool samples were collected once every 4 to 7 days.Viral nucleic acids were detected byfl uorescent polymerase chain reaction until the results became negative.The positive rates of viral nucleic acids were analyzed by the Kaplan-Meier method.The Log-rank test and Cox-Mantel test were used to analyze factors affecting the HFMD children with EV71 infection.Results:On the 2nd,4th,6th and 10th week,the positive rates of viral nucleic acids in stool samples of the 65 children were 94.6%,48.1%,17.2%and 0,respectively.Univariate analysis showed that the intestinal detoxification time of the children were related to gender,pre-admission disease course,severity of disease,and use of steroids or gamma globulin(P<0.05).Multivariate analysis showed that the severity of disease was an independent factor affecting the intestinal detoxification time(P<0.05),with a relative risk of 2.418.Conclusions:The longest intestinal detoxification time of HFMD children with EV71 infection was 10 weeks.The severity of disease was an important factor affecting the intestinal detoxification time of HFMD children with EV71 infection.Severe HFMD children with EV71 infection had a longer intestinal detoxification time.
