Objective To investigate the diagnostic and predictive value of enhanced CT Hounsfield unit value for central lymph node metastasis(CLNM)in patients with Hashimoto’s thyroiditis(HT)complicated with papillary thyroid ...Objective To investigate the diagnostic and predictive value of enhanced CT Hounsfield unit value for central lymph node metastasis(CLNM)in patients with Hashimoto’s thyroiditis(HT)complicated with papillary thyroid carcinoma(PTC).Methods The CT images of HTs with PTC confirmed by operation and pathology from 88 patients were analyzed retrospectively.Among them,50 cases of CLNM were all negative and 38 cases of CLNM were all positive.One lymph node was selected as the study subject in each case.The average HU values(AHUVs)and maximum HU values(MHUVs)were measured on the enhanced CT.The diagnostic efficacy of the two parameters for diagnosing CLNM was analyzed by the receiver operating specificity curve(ROC),and the best cut-off values were obtained,which were used to predict 103 HT with PTC CLNM in the validation group.Results The AHUVs of negative group and positive group were(63.79±15.34)HU and(90.92±18.04)HU(t=8.828,P<0.001).The MHUVs of negative group and positive group were(77.08±15.30)HU and(108.79±18.37)HU,respectively(t=7.615,P<0.001).The AUCs for AHUVs and MHUVs for the diagnosis of CLNM-positive was 0.870 and 0.906,and the cut-off values were 84.0 HU and 96.5 HU,respectively.The sensitivity,specificity,and accuracy of predicting CLNM positivity in the validation group using AHUVs≥84.0 HU were 35.7%,95.1%,and 70.9%,respectively,and MHUVs≥96.5 HU were 38.1%,93.4%,and 70.9%,respectively.Conclusion AHUVs≥84.0 HU and MHUVs≥96.5 HU have high specificity for the diagnosis of HT with PTC CLNM,which can provide an important basis for clinical treatment decision.展开更多
目的探讨单发PTC同侧中央组淋巴结转移(ipsilateral central lymph node metastasis,ICLNM)的各种CT征象,通过多因素回归分析明确其诊断价值。方法回顾分析经手术及病理证实的302例直径〉1.0 cm单发PTC的CT资料,通过受试者操作特性曲线(...目的探讨单发PTC同侧中央组淋巴结转移(ipsilateral central lymph node metastasis,ICLNM)的各种CT征象,通过多因素回归分析明确其诊断价值。方法回顾分析经手术及病理证实的302例直径〉1.0 cm单发PTC的CT资料,通过受试者操作特性曲线(receiver operating characteristic,ROC)获得淋巴结转移直径的最佳阈值,并采用多因素回归分析淋巴结大小、强化程度、钙化或囊变、中央区浑浊和侧颈部淋巴结阳性与ICLNM阳性的关系’结果302例PTC中,病理证实ICLNM阳性和阴性比例分别为63.6%(192/302)和36.4%(110/302)。根据ROC曲线,随着淋巴结直径的增大,诊断淋巴结转移的敏感度降低而特异度增髙,当阈值为0.4 cm时,约登指数最大(0.358),此时敏感度和特异度分别为50.5%和80.3%。多因素分析显示直径≥0.4cm、高强化、中央区浑浊和侧颈部淋巴结阳性是1CLNM阳性的独立风险因子,OR值分别为4.189(95% CI 2.037~8.617),3.875 (95% CI 1.561~9.617),4.054(95% CI 2.230~7.371)和8.735 (95% CI 1.093~69.831);钙化或囊变在ICLNM中差异无统计学意义。结论直径≥0.4cm、高强化冲央区浑浊和侧颈部淋巴结阳性是PTC时ICLNM阳性的独立风险因子,钙化或囊变虽不是独立风险因子,对ICLNM阳性却具有高度准确度,准确识别这些征象,对于外科医生采取更彻底的手术治疗方案及降低术后复发具有重要意义。展开更多
基金Zhejiang Provincial Medical and Health Technology Project(2020RC091,2021RC024)。
文摘Objective To investigate the diagnostic and predictive value of enhanced CT Hounsfield unit value for central lymph node metastasis(CLNM)in patients with Hashimoto’s thyroiditis(HT)complicated with papillary thyroid carcinoma(PTC).Methods The CT images of HTs with PTC confirmed by operation and pathology from 88 patients were analyzed retrospectively.Among them,50 cases of CLNM were all negative and 38 cases of CLNM were all positive.One lymph node was selected as the study subject in each case.The average HU values(AHUVs)and maximum HU values(MHUVs)were measured on the enhanced CT.The diagnostic efficacy of the two parameters for diagnosing CLNM was analyzed by the receiver operating specificity curve(ROC),and the best cut-off values were obtained,which were used to predict 103 HT with PTC CLNM in the validation group.Results The AHUVs of negative group and positive group were(63.79±15.34)HU and(90.92±18.04)HU(t=8.828,P<0.001).The MHUVs of negative group and positive group were(77.08±15.30)HU and(108.79±18.37)HU,respectively(t=7.615,P<0.001).The AUCs for AHUVs and MHUVs for the diagnosis of CLNM-positive was 0.870 and 0.906,and the cut-off values were 84.0 HU and 96.5 HU,respectively.The sensitivity,specificity,and accuracy of predicting CLNM positivity in the validation group using AHUVs≥84.0 HU were 35.7%,95.1%,and 70.9%,respectively,and MHUVs≥96.5 HU were 38.1%,93.4%,and 70.9%,respectively.Conclusion AHUVs≥84.0 HU and MHUVs≥96.5 HU have high specificity for the diagnosis of HT with PTC CLNM,which can provide an important basis for clinical treatment decision.
文摘目的探讨单发PTC同侧中央组淋巴结转移(ipsilateral central lymph node metastasis,ICLNM)的各种CT征象,通过多因素回归分析明确其诊断价值。方法回顾分析经手术及病理证实的302例直径〉1.0 cm单发PTC的CT资料,通过受试者操作特性曲线(receiver operating characteristic,ROC)获得淋巴结转移直径的最佳阈值,并采用多因素回归分析淋巴结大小、强化程度、钙化或囊变、中央区浑浊和侧颈部淋巴结阳性与ICLNM阳性的关系’结果302例PTC中,病理证实ICLNM阳性和阴性比例分别为63.6%(192/302)和36.4%(110/302)。根据ROC曲线,随着淋巴结直径的增大,诊断淋巴结转移的敏感度降低而特异度增髙,当阈值为0.4 cm时,约登指数最大(0.358),此时敏感度和特异度分别为50.5%和80.3%。多因素分析显示直径≥0.4cm、高强化、中央区浑浊和侧颈部淋巴结阳性是1CLNM阳性的独立风险因子,OR值分别为4.189(95% CI 2.037~8.617),3.875 (95% CI 1.561~9.617),4.054(95% CI 2.230~7.371)和8.735 (95% CI 1.093~69.831);钙化或囊变在ICLNM中差异无统计学意义。结论直径≥0.4cm、高强化冲央区浑浊和侧颈部淋巴结阳性是PTC时ICLNM阳性的独立风险因子,钙化或囊变虽不是独立风险因子,对ICLNM阳性却具有高度准确度,准确识别这些征象,对于外科医生采取更彻底的手术治疗方案及降低术后复发具有重要意义。
