Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(...Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear.展开更多
基金supported by the National Natural Science Foundation of China(32070739,31771528,and 91754107)Zhejiang Provincial Natural Science Foundation of China(LR21C070001)+3 种基金the National Basic Research Program of China(2017YFA0503402)to C.YiNatural Science Foundation for Young Scientists of China(81800085)Natural Science Foundation of Hubei Province,China(ZRMS2020002147)to J.TongZhejiang Key R&D Program of China(2019C02030)to L.Zhang。
文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear.
