Engineering a cationic supramolecular charge switch for facile amino acids enantiodiscrimination based on extended-gate field effect transistors

Chiral recognition of essential amino acids(EAAs)is a huge challenge that keeps plaguing analytical scientists due to their cryptochirality and limited steric interaction sites.Inspired by the superior enantioselectivity of functional supramolecular cyclodextrins(CDs)and strong signal amplification ability of field effect transistors(FETs),this work firstly reports a cationic supramolecular charge switch for facile enantiodiscrimination of EAAs based on extended-gate organic FET(EG-OFET).The cationic phenylcarbamoylated-CD single isomer acts as a charge switch via interacting with different enantiomers and the weak stereo-differentiation intermolecular interaction signals between the cationic perphenylcarbamoylated CDs and EAAs on the EG can be strongly and rapidly amplified through an OFET.Efficient chiral differentiation of six EAAs,including phenylalanine,tryptophan,leucine,isoleucine,lysine and valine,are successfully achieved without any derivation process and the detection limit for D-phenylalanine is down to 10^(-13)mol/L.We believe that this study provides a new and facile sensing perspective for natural amino acids and may afford deeper understanding of molecular chirality.