Gastric adenocarcinoma is quite rare in children and as a result very little experience has been reported on with regards to clinical presentation,treatment and outcome.We describe the case of a 16-year-old boy presen...Gastric adenocarcinoma is quite rare in children and as a result very little experience has been reported on with regards to clinical presentation,treatment and outcome.We describe the case of a 16-year-old boy presenting with abdominal fullness and poor appetite for 7 d.Sonography showed massive ascites and computed tomography imaging revealed the presence of gastric mucosa thickness with omentum caking.The diagnosis of gastric adenocarcinoma was biopsyproven endoscopically.Despite gastric adenocarcinoma being quite rare in the pediatric patient population,we should not overlook the possibility of gastric adenocarcinoma when a child presents with distended abdomen and massive ascites.展开更多
Allergen-specific immunotherapy(allergen-SIT)is a highly effective treatment for children with allergic asthma(AA),an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in r...Allergen-specific immunotherapy(allergen-SIT)is a highly effective treatment for children with allergic asthma(AA),an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens.T helper cells and secreted cytokines play important roles in the pathogenesis of asthma,and epigenetic modulation controls genes important for T cell development and cytokine expression.This study evaluated T helper cell-secreted cytokines and DNA methylation patterns in children treated with Dermatophagoides pteronyssinus(Der p)allergen-SIT.Our results showed that after Der p challenge,peripheral blood mononuclear cells(PBMCs)from the SIT group,compared with the non-SIT AA group,produced lower levels of IL-4,IL-5 and IL-2.The SIT group,compared with the AA group,exhibited decreased sensitivity to the Der p allergen,concurrent with IL-4 down-modulation due to increased promoter DNA methylation,as estimated in PBMCs.Our results showed that SIT decreased IL-4 and IL-5,and inhibited T cell proliferation,by inhibiting IL-2 production after the specific allergen challenge.These results suggest that decreased IL-2 production and increased IL-4 cytokine promoter methylation is a potential mechanism of Der p-specific allergen desensitization immunotherapy.展开更多
基金Supported by grants from the Research laboratory of pediatrics,Children’s Hospital of China Medical UniversityChina Medical University Hospital,No.DMR-101-042
文摘Gastric adenocarcinoma is quite rare in children and as a result very little experience has been reported on with regards to clinical presentation,treatment and outcome.We describe the case of a 16-year-old boy presenting with abdominal fullness and poor appetite for 7 d.Sonography showed massive ascites and computed tomography imaging revealed the presence of gastric mucosa thickness with omentum caking.The diagnosis of gastric adenocarcinoma was biopsyproven endoscopically.Despite gastric adenocarcinoma being quite rare in the pediatric patient population,we should not overlook the possibility of gastric adenocarcinoma when a child presents with distended abdomen and massive ascites.
基金This study was supported by a grant from the Ditmanson Medical Foundation Chia-Yi Christian Hospital Research Program(R104-06)in part by the Ministry of Science and Technology(MOST-104-2320-B-194-006,Taiwan)。
文摘Allergen-specific immunotherapy(allergen-SIT)is a highly effective treatment for children with allergic asthma(AA),an immune-mediated chronic disease leading to bronchial muscle hypertrophy and airway obstruction in response to specific allergens.T helper cells and secreted cytokines play important roles in the pathogenesis of asthma,and epigenetic modulation controls genes important for T cell development and cytokine expression.This study evaluated T helper cell-secreted cytokines and DNA methylation patterns in children treated with Dermatophagoides pteronyssinus(Der p)allergen-SIT.Our results showed that after Der p challenge,peripheral blood mononuclear cells(PBMCs)from the SIT group,compared with the non-SIT AA group,produced lower levels of IL-4,IL-5 and IL-2.The SIT group,compared with the AA group,exhibited decreased sensitivity to the Der p allergen,concurrent with IL-4 down-modulation due to increased promoter DNA methylation,as estimated in PBMCs.Our results showed that SIT decreased IL-4 and IL-5,and inhibited T cell proliferation,by inhibiting IL-2 production after the specific allergen challenge.These results suggest that decreased IL-2 production and increased IL-4 cytokine promoter methylation is a potential mechanism of Der p-specific allergen desensitization immunotherapy.
