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Crotonylation of PRKACA enhances PKA activity and promotes colorectal cancer development via the PKA-FAK-AKT pathway
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作者 Jia-Yi Hou Li-Juan Gao +6 位作者 Jing Shen Lan Zhou Jian-Yun Shi Teng Sun shu-lan hao De-Ping Wang Ji-Min Cao 《Genes & Diseases》 SCIE CSCD 2023年第2期332-335,共4页
Colorectal cancer (CRC) is a common cancer with high morbidity and mortality.1 Post-translational modification (PTM) of protein plays an important role in the pathogenesis of CRC. Lysine crotonylation (Kcr) is an impo... Colorectal cancer (CRC) is a common cancer with high morbidity and mortality.1 Post-translational modification (PTM) of protein plays an important role in the pathogenesis of CRC. Lysine crotonylation (Kcr) is an important type of PTM and has been proved evolutionarily conserved in eukaryotic cells from a wide range of species.2 However, the role of protein Kcr in the progression of CRC is unclear. 展开更多
关键词 cancer MORTALITY COLORECTAL
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