Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative...Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.展开更多
Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structu...Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 β-hydroxyl olean-12-en-3-O-[β-D-glucopyranosyl (1 →6)- β-D-glucopyranosyl]-28-O-β-D-glucopyranoside(1) and 16 β,21 β,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H2O extracts of this plant were shown to be able to inhibit glucose absorption in rats.展开更多
Two new cyclic diarylheptanoids named ostryopsitrienol(1) and ostryopsitriol(2),together with six known compounds,were isolated from the stems of endemic medicinal plant of Ostryopsis nobilis (Betulaceae).The st...Two new cyclic diarylheptanoids named ostryopsitrienol(1) and ostryopsitriol(2),together with six known compounds,were isolated from the stems of endemic medicinal plant of Ostryopsis nobilis (Betulaceae).The structures of the new compounds were elucidated by means of HRMS,~1D NMR,~2D NMR and X-ray crystallography analysis.展开更多
基金Financial support from the National Natural Science Foundation of China (Nos.21072184,30973634 and 81173536)
文摘Two novel 27-norergostanol steroids, panthogenins A (1) and B (2), possessing unusual rings E and F featuring a ketal moiety at C-25 were isolated from rhizomes ofDioscorea panthaica. Their structures and relative configurations were elucidated by extensive spectroscopic methods including 1D and 2D NMR techniques, and the structure of panthogenin A was further confirmed by X-ray crystallography. Both compounds showed potent in vitro insulin sensitizing activity.
文摘Two new oleanane-type triterpenoid saponins, gymnemoside-W1 and W2, together with seven known compounds were isolated from the leaves of Gymnema sylvestre R. Br. By means of spectral and chemical analysis, the structures of the new compounds were elucidated as 16 β-hydroxyl olean-12-en-3-O-[β-D-glucopyranosyl (1 →6)- β-D-glucopyranosyl]-28-O-β-D-glucopyranoside(1) and 16 β,21 β,28-trihydroxyl-olean-12-ene-3-O-glucoronopyranoside (2). The EtOH/H2O extracts of this plant were shown to be able to inhibit glucose absorption in rats.
基金financially supported by the grants from the National Natural Sciences Foundation of China(No. 30973634)
文摘Two new cyclic diarylheptanoids named ostryopsitrienol(1) and ostryopsitriol(2),together with six known compounds,were isolated from the stems of endemic medicinal plant of Ostryopsis nobilis (Betulaceae).The structures of the new compounds were elucidated by means of HRMS,~1D NMR,~2D NMR and X-ray crystallography analysis.