Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC...Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC patients are greatly needed.The dysregulation of epigenetic control is one of the common features in cancer.JMJD3 is a histone demethylase specific for H3K27me3/me2 that switches a gene from its repressive state to an active form.1 The dysregulation of JMJD3 is reported to play key roles in many cancer progressions.Recently,JMJD3 was reported to be overexpressed in ESCC,2 but the potential mechanism of JMJD3 in ESCC remains poorly understood.展开更多
文摘Dear Editor,Esophageal squamous cell carcinoma(ESCC)is a common cancer worldwide with a 5-year survival rate less than 25%.Reliable molecular markers that could serve as predictors for diagnosis and treatment for ESCC patients are greatly needed.The dysregulation of epigenetic control is one of the common features in cancer.JMJD3 is a histone demethylase specific for H3K27me3/me2 that switches a gene from its repressive state to an active form.1 The dysregulation of JMJD3 is reported to play key roles in many cancer progressions.Recently,JMJD3 was reported to be overexpressed in ESCC,2 but the potential mechanism of JMJD3 in ESCC remains poorly understood.
