Objective: To study the change of homeobox protein 7 (HOXB7) gene expression in colon cancer lesions and its correlation with the pathological characteristics of tumor. Methods: The patients with colon cancer who unde...Objective: To study the change of homeobox protein 7 (HOXB7) gene expression in colon cancer lesions and its correlation with the pathological characteristics of tumor. Methods: The patients with colon cancer who underwent radical resection in Tangshan Hospital of Traditional Chinese Medicine between March 2015 and February 2018 were selected as the research subjects, and right amount of colon cancer lesions and lesions adjacent to carcinoma were collected to measure the expression of HOXB7 gene, cell proliferation-related genes Notch1, Hes1, P53, ASPP2 and WTX as well as invasion-related genes CAT-D, TMEM16a, CBX7, ZEB1, E-cadherin and N-cadherin. Results: HOXB7, Notch1, Hes1, CAT-D, TMEM16a, CBX7, ZEB1 and N-cadherin mRNA expression in colon cancer lesions were higher than those in adjacent lesions whereas P53, ASPP2, WTX and E-cadherin mRNA expression were lower than those in adjacent lesions;the mRNA of HOXB7 gene in colon cancer was positively correlated with the mRNA expression of Notch1, Hes1, CAT-D, TMEM16a, CBX7, ZEB1 and N-cadherin, and negatively correlated with the mRNA expression of P53, ASPP2, WTX and E-cadherin. Conclusion: The high expression of HOXB7 gene in the colon cancer lesions can enhance the pathological characteristics of tumor proliferation and invasion.展开更多
文摘Objective: To study the change of homeobox protein 7 (HOXB7) gene expression in colon cancer lesions and its correlation with the pathological characteristics of tumor. Methods: The patients with colon cancer who underwent radical resection in Tangshan Hospital of Traditional Chinese Medicine between March 2015 and February 2018 were selected as the research subjects, and right amount of colon cancer lesions and lesions adjacent to carcinoma were collected to measure the expression of HOXB7 gene, cell proliferation-related genes Notch1, Hes1, P53, ASPP2 and WTX as well as invasion-related genes CAT-D, TMEM16a, CBX7, ZEB1, E-cadherin and N-cadherin. Results: HOXB7, Notch1, Hes1, CAT-D, TMEM16a, CBX7, ZEB1 and N-cadherin mRNA expression in colon cancer lesions were higher than those in adjacent lesions whereas P53, ASPP2, WTX and E-cadherin mRNA expression were lower than those in adjacent lesions;the mRNA of HOXB7 gene in colon cancer was positively correlated with the mRNA expression of Notch1, Hes1, CAT-D, TMEM16a, CBX7, ZEB1 and N-cadherin, and negatively correlated with the mRNA expression of P53, ASPP2, WTX and E-cadherin. Conclusion: The high expression of HOXB7 gene in the colon cancer lesions can enhance the pathological characteristics of tumor proliferation and invasion.
