Cardiovascular protective properties of gastrodin

Cardiovascular diseases cause significant morbidity and mortality worldwide,incurring a major public health burden.Gastrodia elata Blume is a traditional Chinese herbal medicine that has been widely used to treat central nervous system and cardiovascular diseases.Gastrodin,as the major active component in Gastrodia elata Blume,can confer protection against cardiovascular diseases.In this review,we summarize the anti-inflammatory actions,anti-cardiac hypertrophy,anti-hypertension,anti-atherosclerosis,and angiogenic effects of gastrodin,as well as its protective effects on vascular cells and against myocardial ischemia-reperfusion injury.The medical potential of gastrodin in diabetes-related cardiovascular diseases is also discussed.

Effect of compound field on horizontal continuous casting of Al-1wt.%Si alloy

A travel ing magnetic field, a power ultrasonic field, and a compound field were used separately during the horizontal continuous casting process of Al-1wt.%Si al oy. The samples obtained were characterized using an optical microscope, a scanning electron microscope, a tensile testing machine, and an electron probe microscopic analyzer to test the microstructures, properties, and element distribution of the samples. The results show that the application of a single ifeld can enhance the mechanical properties and reduce the segregation of Si element in Al-1wt.%Si alloy to some extent. The application of a compound field can obtain the best reifnement and homogeneity of the Si element in the al oy, leading to the highest increase of tensile strength and elongation among the three applied ifelds. The mechanism of the action of external ifelds on the reifnement of microstructures and homogeneity of the Si element is discussed and the compound ifeld is considered to be an effective method to achieve high quality Al alloys.

Deficiency of Trp53 and Rb1 in myeloid cell lineage spontaneously develops acute myeloid leukemia in a mouse model

Acute myeloid leukemia(AML)is a rapidly lethal blood cancer characterized by aberrant proliferation and differentiation of myeloid progenitors in the hematopoietic tissue.In recent decades,AML patients are significantly increased.In 2019 alone,21,450 new AML cases were diagnosed in the United States,with an estimated 10,920 deaths due to AML.What’s worse,AML occurs with an increasing incidence with advanced age,and the survival rate remains dismal with a median overall survival of only 5e10 months.Notwithstanding great advances in allogenic transplant and chemotherapy,the therapeutic outcomes are unfavorable due to the disease relapse and mortality rates.More importantly,the development of more specific and effective therapies was hampered in part by the lack of proper animal models for AML.Thus,management and elucidation of the pathological mechanism of AML remain an ongoing challenge,and the development of effective AML mouse models and treatment options are urgently needed.

RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment

Dear Editor,Multiple myeloma(MM)is a malignant plasma cancer that grows in the bone marrow and migrates through the bloodstream.Fifty-eight percent of MM patients exhibit the phenotype of hepatomegaly,and 40%have myeloma cell infiltration in the liver[1].The occurrence and migration of MM are highly associated with the bone marrow microenvironment[2].A key in the develop-ment of MM is the evasion and suppression of the host immune system.Monocyte/macrophage-lineage cells are major components of the infiltrating leukocytes in tumors.