Eosinophilia complicated with venous thromboembolism:A case report

BACKGROUND Eosinophilia is an increase of more than 0.5×109/L in the number of eosinophils;it is a systemic condition with an unknown etiology and is often accompanied by multiple impaired organ functions.The clinical manifestations of the disease are highly variable and diverse,rendering identification of the diagnosis challenging;hence,diagnosis and treatment are often delayed.Very few reports of this disease exist globally,especially with rare manifestations of cerebral venous sinus thrombosis and hemorrhage.CASE SUMMARY A 32-year-old woman with eosinophilia presented to the hospital with bilateral lower-limb edema as the first clinical manifestation,followed by an extensive maculopapular rash throughout the body.She subsequently developed cerebral venous sinus thrombosis along with bilateral lower-limb deep vein thrombosis.Two weeks earlier,she had received a single course of antibiotics from a local hospital for a low-grade fever and sore throat.After various treatments were administered for anticoagulation,maintaining blood circulation,and relieving blood stasis,the lower extremity edema improved significantly;however,the patient’s eosinophil count gradually increased.She experienced cerebral venous sinus thrombosis,cerebral hemorrhage,and deep vein thrombosis of the lower limbs before being declared brain dead.In this case report,we have elaborated the diagnosis and management of deep vein thrombosis manifested as eosinophilia,thrombocytopenia,and elevated D-dimer levels.CONCLUSION Because proper diagnosis is challenging,clinical vigilance is required for patients with eosinophilia,as it can lead to thrombus formation.

Professor Jia Chunsheng's instruction on clinical application of"elements for acupuncture effect orientation"in the Song to Elucidate Mysteries

Professor Jia Chunsheng is one of the sixth of old traditional Chinese medicine experts,and often instructs students in ordinary clinics to attach importance to learning and clinical practices of classic works.Now Professor Jia Chunsheng selects a poet-Song to Elucidate Mysteries in the Guidelines of Acupuncture Classic by Dou Hanqing in the Jin and Yuan Dynasties,and requires the students to read carefully,investigate deeply,and apply at times;Moreover,Professor Jia Chunsheng discusses the"important factors to achieve good clinical therapeutic effects by acupuncture"contained in the Song to Elucidate Mysteries,in many aspects of understanding acupoint characteristics,defining clearly acupoint compatibility,selecting appropriate needling manipulation,how to determine needling depth,how to determine needling direction,how to determine needle retention time,and how to select acupuncture&moxibustion method,etc.Now they are discussed as follows,to discover and spread Dou's acupuncture technique and to increase clinical therapeutic effects.

Fungal diversity notes 1277-1386:taxonomic and phylogenetic contributions to fungal taxa

This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and strain culture,combined with DNA sequence analyses.110 taxa are described and illustrated,including five new genera,92 new species,eight new combinations and other taxonomic contributions(one new sequenced species,one new host and three new records)which are accommodated in 40 families and 1 incertae sedis in Dothideomycetes.The new genera are Amyloceraceomyces,Catenuliconidia,Hansenopezia,Ionopezia and Magnopulchromyces.The new species are Amyloceraceomyces angustisporus,Amylocorticium ellipsosporum,Arthrinium sorghi,Catenuliconidia uniseptata,Clavulina sphaeropedunculata,Colletotrichum parthenocissicola,Coniothyrium triseptatum,Cortinarius indorusseus,C.paurigarhwalensis,C.sinensis,C.subsanguineus,C.xiaojinensis,Diaporthe pimpinel-lae,Dictyosporella guizhouensis,Diplodia torilicola,Fuscoporia marquesiana,F.semiarida,Hansenopezia decora,Helicoarcta-tus thailandicus,Hirsutella hongheensis,Humidicutis brunneovinacea,Lentaria gossypina,L.variabilis,Lycoperdon lahorense,L.pseudocurtisii,Magnopulchromyces scorpiophorus,Moelleriella gracilispora,Neodevriesia manglicola,Neodidymelliopsis salvia,N.urticae,Neoroussoella magnoliae,Neottiella gigaspora,Ophiosphaerella chiangraiensis,Phaeotremella yunnanensis,Podosphaera yulii,Rigidoporus juniperinus,Rhodofomitopsis pseudofeei,Russula benghalensis,Scleroramularia vermispora,Scytinopogon minisporus,Sporormurispora paulsenii,Thaxteriellopsis obliqus,Tomentella asiae-orientalis,T.atrobadia,T.atrocastanea,T.aureomarginata,T.brevis,T.brunneoflava,T.brunneogrisea,T.capitatocystidiata,T.changbaiensis,T.citri-nocystidiata,T.coffeae,T.conclusa,T.cystidiata,T.dimidiata,T.duplexa,T.efibulata,T.efibulis,T.farinosa,T.flavidobadia,T.fuscocrustosa,T.fuscofarinosa,T.fuscogranulosa,T.fuscopelliculosa,T.globospora,T.gloeocystidiata,T.griseocastanea,T.griseofusca,T.griseomarginata,T.inconspicua,T.incrustata,T.interrupta,T.liaoningensis,T.longiaculeifera,T.longiechinuli,T.megaspora,T.olivacea,T.olivaceobrunnea,T.pallidobrunnea,T.pallidomarginata,T.parvispora,T.pertenuis,T.qingyuanensis,T.segregata,T.separata,T.stipitata,T.storea,Trichoderma ceratophylletum,Tyromyces minutulus,Umbelopsis heterosporus and Xylolentia reniformis.The new combinations are Antrodiella descendena,Chloridium macrocladum,Hansenopezia retrocurvata,Rhodofomitopsis monomitica,Rh.oleracea,Fuscoporia licnoides,F.scruposa and Ionopezia gerardii.A new sequenced species(Graphis supracola),one new host(Aplosporella prunicola)and three new geographical records(Golovinomyces monardae,Paradictyoarthrinium diffractum and Prosthemium betulinum),are reported.