RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed ...RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40,respectively. In this study,we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication.展开更多
In the framework of nonlinear wave optics,we report the evolution process of a dipole breathing wave in lossy nonlocal nonlinear media based on the nonlocal nonlinear Schrödinger equation.The analytical expressio...In the framework of nonlinear wave optics,we report the evolution process of a dipole breathing wave in lossy nonlocal nonlinear media based on the nonlocal nonlinear Schrödinger equation.The analytical expression of the dipole breathing wave in such a nonlinear system is obtained by using the variational method.Taking advantage of the analytical expression,we analyze the influences of various physical parameters on the breathing wave propagation,including the propagation loss and the input power on the beam width,the beam intensity,and the wavefront curvature.Also,the corresponding analytical solutions are obtained.The validity of the analysis results is verified by numerical simulation.This study provides some new insights for investigating beam propagation in lossy nonlinear media.展开更多
基金The Nation "863" Program of China(2006AA02A226)The Joint Funds of National Science Foundation of China (U0632010)+2 种基金The State KeyLaboratory of Phytochemistry and Plant Resources in West ChinaChinese Academy of Sciences (O807B11211, O807E21211)"211 grant of MOE"
文摘RNA interference (RNAi) is a process by which introduced small interfering RNA (siRNA) can cause the specific degradation of mRNA with identical sequences. The human herpes simplex virus type 1 (HSV-1) RR is composed of two distinct homodimeric subunits encoded by UL39 and UL40,respectively. In this study,we applied siRNAs targeting the UL39 and UL40 genes of HSV-1. We showed that synthetic siRNA silenced effectively and specifically UL39 and UL40 mRNA expression and inhibited HSV-1 replication. Our work offers new possibilities for RNAi as a genetic tool for inhibition of HSV-1 replication.
基金the National Natural Science Foundation of China(Grant No.12074098)the Natural Science Foundation of Hebei Province of China(Grant Nos.A2020205009 and F2020205016)+2 种基金the Science and Technology Project of Hebei Education Department,China(Grant No.ZD2018081)the Chunhui Plan of Ministry of Education of China(Grant No.Z2017020)the Science Foundation for Distinguished Young Scholars of Hebei Normal University of China(Grant No.L2017J02).
文摘In the framework of nonlinear wave optics,we report the evolution process of a dipole breathing wave in lossy nonlocal nonlinear media based on the nonlocal nonlinear Schrödinger equation.The analytical expression of the dipole breathing wave in such a nonlinear system is obtained by using the variational method.Taking advantage of the analytical expression,we analyze the influences of various physical parameters on the breathing wave propagation,including the propagation loss and the input power on the beam width,the beam intensity,and the wavefront curvature.Also,the corresponding analytical solutions are obtained.The validity of the analysis results is verified by numerical simulation.This study provides some new insights for investigating beam propagation in lossy nonlinear media.
