The underground thermal fluid is one of the significant factors controlling the formation and quality of reservoirs.The Huangliu Formation(N_(1)h)in YF1 area of the central depression belt in the Yinggehai Basin,South...The underground thermal fluid is one of the significant factors controlling the formation and quality of reservoirs.The Huangliu Formation(N_(1)h)in YF1 area of the central depression belt in the Yinggehai Basin,South China Sea,is characterized by intense thermal fluid activities related to mud diapir and large-scale shallow-water gravity flow deposits.The multi-episodic invasion of high-temperature and CO_(2)-rich thermal fluid into the formation induces complex water-rock reaction during diagenetic pro-cess,providing a preferable investigation opportunity for revealing how thermal fluid affects reservoir quality.This study characterizes the reservoirs in the formation through core and thin section analyses as well as physical property test.The reservoirs are dominated by fine-grained sandstone characterized by medium porosity(15.2-21.3%)and lower permeability(0.56-15.75mD).Based on an analysis of casting thin section,cathode luminescence(CL),scanning electron microscope(SEM),carbon and oxygen isotope,inclusion test,and electron-probe microanalysis(EPMA),we systematically investigate the diagenetic patterns and pore evolution process for the reservoirs in the formation.The episodic invasion of thermal fluid occurred approximately 0.4 Ma ago plays an important role in controlling reservoir development:The CO_(2)-rich formation water induces massive late-stage dissolution,resulting in a higher proportion of dissolved pores(38.7-46.4%),which improves the porosity of reservoirs at a depth of 2600-3100 m.Nevertheless,the late dissolution together with carbonate cementation occurred in closed diagenetic system blocks most seepage channels.Furthermore,the relatively high level clay mineral transformation in the YF1 area leads to a higher content of authigenic illite(44-62%)in the formation.Massive authigenic illite severely blocks the pore throats in fine sandstone,reducing permeability.This study offers an insight to the understanding of mud diapir-derived thermal fluid affecting and controlling the quality of reservoirs in some areas of the Yinggehai Basin.展开更多
Alzheimer’s disease(AD)is a typical neurodegenerative disease that leads to irreversible neuronal degeneration,and effective treatment remains elusive due to the unclear mechanism.We utilized biocompatible mesenchyma...Alzheimer’s disease(AD)is a typical neurodegenerative disease that leads to irreversible neuronal degeneration,and effective treatment remains elusive due to the unclear mechanism.We utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with the CB2 target medicine AM1241(EVs-AM1241)to protect against neurodegenerative progression and neuronal function in AD model mice.According to the results,EVs-AM1241 were successfully constructed and exhibited better bioavailability and therapeutic effects than bare AM1241.The Morris water maze(MWM)and fear conditioning tests revealed that the learning and memory of EVs-AM1241-treated model mice were significantly improved.In vivo electrophysiological recording of CA1 neurons indicated enhanced response to an auditory conditioned stimulus following fear learning.Immunostaining and Western blot analysis showed that amyloid plaque deposition and amyloidβ(Aβ)-induced neuronal apoptosis were significantly suppressed by EVs-AM1241.Moreover,EVs-AM1241 increased the number of neurons and restored the neuronal cytoskeleton,indicating that they enhanced neuronal regeneration.RNA sequencing revealed that EVs-AM1241 facilitated Aβphagocytosis,promoted neurogenesis and ultimately improved learning and memory through the calcium-Erk signaling pathway.Our study showed that EVs-AM1241 efficiently reversed neurodegenerative pathology and enhanced neurogenesis in modelmice,indicating that they are very promising particles for treating AD.展开更多
We explore the imaginary-time relaxation dynamics near quantum critical points with semi-ordered initial states.Different from the case with homogeneous ordered initial states,in which the order parameter M decays hom...We explore the imaginary-time relaxation dynamics near quantum critical points with semi-ordered initial states.Different from the case with homogeneous ordered initial states,in which the order parameter M decays homogeneously as M∝τ^(-β/vz),here M depends on the location x,showing rich scaling behaviors.Similar to the classical relaxation dynamics with an initial domain wall in model A,which describes the purely dissipative dynamics,here as the imaginary time evolves,the domain wall expands into an interfacial region with growing size.In the interfacial region,the local order parameter decays as M∝τ^(-β1/vz),withβ_(1)being an additional dynamic critical exponent.Far away from the interfacial region the local order parameter decays as M∝τ-β/vz in the short-time stage,then crosses over to the scaling behavior of M∝τ^(-β1/vz)when the location x is absorbed in the interfacial region.A full scaling form characterizing these scaling properties is developed.The quantum Ising model in both one and two dimensions are taken as examples to verify the scaling theory.In addition,we find that for the quantum Ising model the scaling function is an analytical function andβ_(1)is not an independent exponent.展开更多
Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlyin...Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging. A total of 105 patients with functional dyspepsia will be allocated into 3 groups: the low-He point group(puncturing at Zusanli(ST36)), Mu point group(puncturing at Zhongwan(CV12)), and He-Mu point combination group(puncturing at ST36 and CV12). Every participant will receive 20 sessions of manual acupuncture for 4 weeks. The needles will be inserted perpendicularly to a depth of 1 to 2 cun. The angle of rotation and twisting will range from 90 to 180 degrees, while lifting and thrusting will range from 0.3 to 0.5 cm. The various manipulations will be performed 60 to 90 times per minute. The needles will remain in place for 30 minutes, during which manipulation will be applied every 10 minutes. Magnetic resonance imaging will be performed before and after 20 sessions of acupuncture. The primary outcome is symptom improvement according to the Chinese version of the Nepean Dyspepsia Index. Secondary outcomes include the Leeds dyspepsia questionnaire, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Beck Anxiety Inventory, Beck Depression Inventory, and visual analogue scale scores before and after 10 and 20 sessions of acupuncture. Needle sensation and adverse events will be used to assess the therapeutic effects. This study will promote more widespread awareness of the benefits of acupoint combination in the clinical setting and provide a further explanation of the neuromechanism by which acupuncture at the He-Mu point combination for functional dyspepsia. Registration: Chinese Clinical Trial Registry, Chi CTR-IOR-15006402.展开更多
Background: The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack of randomized control studies. This study aimed to investigate the possible benefit of postoperative a...Background: The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack of randomized control studies. This study aimed to investigate the possible benefit of postoperative adjuvant chemotherapy for resectable cholangiocarcinoma. Data sources: Relevant research articles published before 1 st March 2018 in Pub Med, Embase and the Cochrane library databases were retrieved. Published data were extracted and analyzed by RevMan 5.3, and the results were presented as hazard ratios(HRs) [95% confidence intervals(CI)] and forest plots. Results: One prospective and eighteen retrospective studies were included, with a total number of 11,458 patients, 4696 of whom received postoperative chemotherapy. There was a significant improvement of the overall survival(OS) for patients who underwent operation + adjuvant chemotherapy compared to those who underwent operation alone(HR = 0.61; P < 0.001). Subgroup analyses show that the postoperative chemotherapy group compared with operation alone group are indicated as follows: hilar cholangiocarcinoma group(HR = 0.60; P < 0.001), intrahepatic cholangiocarcinoma group(HR = 0.60; P < 0.001), R1 resection group(HR = 0.71; P = 0.04), LN-positive diagnosis group(HR = 0.58; P < 0.001), gemcitabine-based chemotherapy group(HR = 0.42; P < 0.001), distal cholangiocarcinoma group(HR = 0.48; P = 0.17), R0 resection group(HR = 0.69; P = 0.43), and 5-flurouracil-based chemotherapy group(HR = 0.90; P = 0.66), respectively. Conclusions: Postoperative adjuvant chemotherapy can improve the OS in intrahepatic and hilar cholangiocarcinoma patients. However, distal cholangiocarcinoma patients gain no benefit from postoperative adjuvant chemotherapy. Prospective randomized trials are warranted in order to define the standard chemotherapy regimen.展开更多
[Objective]The study aimed at evaluating the ability to save energy and reduce CO 2 emission in China's cement industry.[Method] Based on long-term energy alternative planning system software(LEAP)," LEAP of ...[Objective]The study aimed at evaluating the ability to save energy and reduce CO 2 emission in China's cement industry.[Method] Based on long-term energy alternative planning system software(LEAP)," LEAP of China's cement industry" model was established to simulate energy conservation and emission reduction in China's cement industry from 2010 to 2040 in different technologic situations.[Result]To save energy and reduce CO 2 emissions,new dry process kiln has priority over other technologies or measures,followed by equipment enlargement,mechanical shaft kiln,power generation system based on waste heat,as well as high-efficiency and energy-saving grinding technology,and new preparation technology.If all the advanced technologies and measures are adopted,energy consumption and CO 2 emissions can be reduced by about 40.76% and 42.97% respectively.[Conclusion]LEAP of model is suitable for analyzing energy saving and emission reducing in China's cement industry and other industrial fields.展开更多
In recent years,the discovery of the Jurassic oil reservoirs in the Western Thrust Belt of the Ordos Basin reveals that the Jurassic formation in this area has huge oil and gas potential.The pre-Jurassic paleo-geomorp...In recent years,the discovery of the Jurassic oil reservoirs in the Western Thrust Belt of the Ordos Basin reveals that the Jurassic formation in this area has huge oil and gas potential.The pre-Jurassic paleo-geomorphology plays a vital role in the formation of the Jurassic oil reservoirs.In this paper,the impression method is applied to restore the pre-Jurassic paleogeomorphology of the Hongde area in the western Ordos Basin,using a large number of drilling,logging,well testing and the latest 3D seismic data.The pre-Jurassic paleogeomorphological units in the study area can be categorized into five groups,including ancient channel valley,ancient terrace,slope,interchannel mound,and low residual mound facies.The oil reservoirs are mainly distributed in highland areas such as slope belts and low residual mounds,the main areas where hydrocarbons accumulate.In addition,the branch ditches in the study area are developed to the southeast and merged into the Ganshan ancient channel.The sandstone in the confluence area of the branch gully is well sorted and connected under frequent scouring by the river.The sand bodies of good connectivity therefore form a drainage system for long-term hydrocarbon migration.The formation of the Jurassic reservoirs in the study area is mainly affected by sedimentary facies,deposition location,and hydrocarbon migration pathway(or fault)of pre-Jurassic paleo-morphology.The results from this study can be useful for the prediction of the Jurassic sweet spots in the western margin of the Ordos Basin.展开更多
The decomposition of coarse woody debris(CWD)affects the energy flow and nutrient cycling in forest ecosystems.Previous studies on CWD have focused on the input,decomposition,reserve dynamics,and CWD functions,but coa...The decomposition of coarse woody debris(CWD)affects the energy flow and nutrient cycling in forest ecosystems.Previous studies on CWD have focused on the input,decomposition,reserve dynamics,and CWD functions,but coarse woody debris decomposition is complex and the results from different regions vary considerably.It is not clear which factors affect decay rate(k),especially at different decomposition stages.In this study,a single-exponential decay model was used to analyze the characteristics of CWD decomposition in Larix gmelinii forests over the 33 years following a fire in the Greater Khingan Mountains.The results show that the decay rate of coarse woody debris was positively correlated to decay class.The average decomposition rate was 0.019,and 41 years and 176 years are needed for a 50%and 95%mass loss,respectively.CWD nutrient content,density,and water content could explain the variance in the decay rate(~42%)of the decay factors such as amount of leaching,degree of fragmentation,respiration of the debris,and biotransformation,and varied significantly between different decay classes.Using the space-time substitution method,this study arranged the coarse woody debris of different mortality times to form a 33 year chronosequence which revealed the decomposition process.It was concluded that the decay rate was mainly explained by structural component of the debris and its nitrogen and water contents.This paper quantifies the indicators affecting CWD decay to explain the decomposition process.展开更多
Symmetry breaking plays a pivotal role in modern physics.Although self-similarity is also a symmetry,and appears ubiquitously in nature,a fundamental question arises as to whether self-similarity breaking makes sense ...Symmetry breaking plays a pivotal role in modern physics.Although self-similarity is also a symmetry,and appears ubiquitously in nature,a fundamental question arises as to whether self-similarity breaking makes sense or not.Here,by identifying an important type of critical fluctuation,dubbed‘phases fluctuations’,and comparing the numerical results for those with self-similarity and those lacking self-similarity with respect to phases fluctuations,we show that self-similarity can indeed be broken,with significant consequences,at least in nonequilibrium situations.We find that the breaking of self-similarity results in new critical exponents,giving rise to a violation of the well-known finite-size scaling,or the less well-known finite-time scaling,and different leading exponents in either the ordered or the disordered phases of the paradigmatic Ising model on two-or three-dimensional finite lattices,when subject to the simplest nonequilibrium driving of linear heating or cooling through its critical point.This is in stark contrast to identical exponents and different amplitudes in usual critical phenomena.Our results demonstrate how surprising driven nonequilibrium critical phenomena can be.The application of this theory to other classical and quantum phase transitions is also anticipated.展开更多
Carbon dioxide (CO<sub>2</sub>) is one of the most important greenhouse gases;its concentration and distribution have important implications on climate change. The El Ni?o Southern Oscillation (ENSO) is th...Carbon dioxide (CO<sub>2</sub>) is one of the most important greenhouse gases;its concentration and distribution have important implications on climate change. The El Ni?o Southern Oscillation (ENSO) is the Earth’s strongest climate fluctuation on inter-annual time scales and has global impacts. However, to date, there is no research on how ENSO affects the spatial distribution of CO<sub>2</sub> concentration. In this study, we used spatial CO<sub>2</sub> data from the ENVIronmentSATellite (ENVISAT) and the Greenhouse Gases Observing Satellite (GOSAT), the long duration monthly mean atmospheric CO<sub>2</sub> from Mauna Loa Observatory, Multivariate ENSO Index (MEI) from Earth System Research Laboratory to analyze the way that ENSO affects spatial distribution of CO<sub>2</sub> concentration in South America, which is affected by ENSO seriously. Our research revealed that monthly CO<sub>2</sub> growth rate has a moderate, positive correlation relationship with MEI. We used geostatistics to predict and simulate the spatial distribution of CO<sub>2</sub> and found that in south of 12°S, CO<sub>2</sub> concentration of ENSO warm episode is lower than the one of ENSO cold and neutral episodes. ENSO impacts CO<sub>2</sub> spatial distribution mainly in November, December, January and February;moderate-high concentration zone of ENSO warm episode more concentrates in the northern part of South America.展开更多
The theoretical relationship between water injection multiple(i.e.injected pore volume)and water saturation is inferred from theoretical concepts of reservoir engineering.A mathematical model based on core displacemen...The theoretical relationship between water injection multiple(i.e.injected pore volume)and water saturation is inferred from theoretical concepts of reservoir engineering.A mathematical model based on core displacement tests is established for the entire injection process that satisfies both initial displacement and extreme displacement,simultaneously.The results show that prior to the flooding,the water injection multiple has a linear relationship with the water saturation,and the utilization rate of the injected water is the highest.As water breakthrough at the production end,the water-cut increases,and the injection multiple increases exponentially while the utilization efficiency of the injected water gradually decreases.When the injection multiple approaches infinity,the utilization efficiency of the injected water gradually decreases to 0,by which time the water-cut at the production end is always 1.At this time,the water saturation no longer changes,and the water flooding recovery rate reaches its limit.Based on the experimental test data,a mathematical model of the entire process of injection multiple and water saturation is established,which has high fitting accuracy that can predict the injection multiple in the different stages of development of a mature oil reservoir.The dynamically changing index of the injection water utilization efficiency in reservoir development by reactive water flooding can be obtained through reasonable transformation of the mathematical model.This is of great significance in guiding evaluations of the effects of reservoir development and formulating countermeasures.展开更多
Unconventional resources will significantly add to the petro-leum reserves and their contribution to global gas/oil production is expected to increase to 25%over the next two decades.However,unconventional reservoirs ...Unconventional resources will significantly add to the petro-leum reserves and their contribution to global gas/oil production is expected to increase to 25%over the next two decades.However,unconventional reservoirs of coal methane,shale gas,tight sand-stone gas and gas hydrate have complex pore structures and are typically tight with porosity and permeability much lower than conventional reservoirs(Pang et al.,2022;Yin et al.,2018a,2018b).The characterization of the pore structure and the study of micro-scale multiphase flow mechanism are extremely impor-tant for the understanding of unconventional reservoirs.Recent studies show that emerging methodologies have become the most powerful in characterizing the dynamics of liquids in porous media from the nano-pore to fracture scale.展开更多
Spinal cord injury triggers complex pathological cascades,resulting in destructive tissue damage and incomplete tissue repair.Scar formation is generally considered a barrier for regeneration in the central nervous sy...Spinal cord injury triggers complex pathological cascades,resulting in destructive tissue damage and incomplete tissue repair.Scar formation is generally considered a barrier for regeneration in the central nervous system.However,the intrinsic mechanism of scar formation after spinal cord injury has not been fully elucidated.Here,we report that excess cholesterol accumulates in phagocytes and is inefficiently removed from spinal cord lesions in young adult mice.Interestingly,we observed that excessive cholesterol also accumulates in injured peripheral nerves but is subsequently removed by reverse cholesteroltransport.Meanwhile,preventing reverse cholesterol transport leads to macrophage accumulation and fibrosis in injured peripheral nerves.Furthermore,the neonatal mouse spinal cord lesions are devoid of myelin-derived lipids and can heal without excess cholesterol accumulation.We found that transplantation of myelin into neonatal lesions disrupts healing with excessive cholesterol accumulation,persistent macrophage activation,and fibrosis.Myelin internalization suppresses macrophage apoptosis mediated by CD5L expression,indicating that myelin-derived cholesterol plays a critical role in impaired wound healing.Taken together,our data suggest that the central nervous system lacks an efficient approach for cholesterol clearance,resulting in excessive accumulation of myelin-derived cholesterol,thereby inducing scar formation after injury.展开更多
文摘The underground thermal fluid is one of the significant factors controlling the formation and quality of reservoirs.The Huangliu Formation(N_(1)h)in YF1 area of the central depression belt in the Yinggehai Basin,South China Sea,is characterized by intense thermal fluid activities related to mud diapir and large-scale shallow-water gravity flow deposits.The multi-episodic invasion of high-temperature and CO_(2)-rich thermal fluid into the formation induces complex water-rock reaction during diagenetic pro-cess,providing a preferable investigation opportunity for revealing how thermal fluid affects reservoir quality.This study characterizes the reservoirs in the formation through core and thin section analyses as well as physical property test.The reservoirs are dominated by fine-grained sandstone characterized by medium porosity(15.2-21.3%)and lower permeability(0.56-15.75mD).Based on an analysis of casting thin section,cathode luminescence(CL),scanning electron microscope(SEM),carbon and oxygen isotope,inclusion test,and electron-probe microanalysis(EPMA),we systematically investigate the diagenetic patterns and pore evolution process for the reservoirs in the formation.The episodic invasion of thermal fluid occurred approximately 0.4 Ma ago plays an important role in controlling reservoir development:The CO_(2)-rich formation water induces massive late-stage dissolution,resulting in a higher proportion of dissolved pores(38.7-46.4%),which improves the porosity of reservoirs at a depth of 2600-3100 m.Nevertheless,the late dissolution together with carbonate cementation occurred in closed diagenetic system blocks most seepage channels.Furthermore,the relatively high level clay mineral transformation in the YF1 area leads to a higher content of authigenic illite(44-62%)in the formation.Massive authigenic illite severely blocks the pore throats in fine sandstone,reducing permeability.This study offers an insight to the understanding of mud diapir-derived thermal fluid affecting and controlling the quality of reservoirs in some areas of the Yinggehai Basin.
基金supported by the National Key Research and Development Program (grant no. 2021YFA1101301)the National Natural Science Foundation of China (grant no. 82225027, 82271419, 81820108013, 62127810, 81901902)+1 种基金Shanghai Rising-Star Program (grant no. 22QA1408200)the Fundamental Research Funds for the Central Universities(no. 22120220555, no. 22120230292, no. 22120230138)
文摘Alzheimer’s disease(AD)is a typical neurodegenerative disease that leads to irreversible neuronal degeneration,and effective treatment remains elusive due to the unclear mechanism.We utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with the CB2 target medicine AM1241(EVs-AM1241)to protect against neurodegenerative progression and neuronal function in AD model mice.According to the results,EVs-AM1241 were successfully constructed and exhibited better bioavailability and therapeutic effects than bare AM1241.The Morris water maze(MWM)and fear conditioning tests revealed that the learning and memory of EVs-AM1241-treated model mice were significantly improved.In vivo electrophysiological recording of CA1 neurons indicated enhanced response to an auditory conditioned stimulus following fear learning.Immunostaining and Western blot analysis showed that amyloid plaque deposition and amyloidβ(Aβ)-induced neuronal apoptosis were significantly suppressed by EVs-AM1241.Moreover,EVs-AM1241 increased the number of neurons and restored the neuronal cytoskeleton,indicating that they enhanced neuronal regeneration.RNA sequencing revealed that EVs-AM1241 facilitated Aβphagocytosis,promoted neurogenesis and ultimately improved learning and memory through the calcium-Erk signaling pathway.Our study showed that EVs-AM1241 efficiently reversed neurodegenerative pathology and enhanced neurogenesis in modelmice,indicating that they are very promising particles for treating AD.
基金the National Natural Science Foundation of China(Grant No.12104109)the Science and Technology Projects in Guangzhou(Grant No.202201020222)+1 种基金supported by the Science and Technology Projects in Guangzhou(Grant No.202102020367)the Fundamental Research Funds for Central Universities,Sun Yat-Sen University(Grant No.22qntd3005)。
文摘We explore the imaginary-time relaxation dynamics near quantum critical points with semi-ordered initial states.Different from the case with homogeneous ordered initial states,in which the order parameter M decays homogeneously as M∝τ^(-β/vz),here M depends on the location x,showing rich scaling behaviors.Similar to the classical relaxation dynamics with an initial domain wall in model A,which describes the purely dissipative dynamics,here as the imaginary time evolves,the domain wall expands into an interfacial region with growing size.In the interfacial region,the local order parameter decays as M∝τ^(-β1/vz),withβ_(1)being an additional dynamic critical exponent.Far away from the interfacial region the local order parameter decays as M∝τ-β/vz in the short-time stage,then crosses over to the scaling behavior of M∝τ^(-β1/vz)when the location x is absorbed in the interfacial region.A full scaling form characterizing these scaling properties is developed.The quantum Ising model in both one and two dimensions are taken as examples to verify the scaling theory.In addition,we find that for the quantum Ising model the scaling function is an analytical function andβ_(1)is not an independent exponent.
基金supported by the National Scientific Foundation Committee in China,No.81473602the Education Ministry’s New Century Excellent Talents Supporting Plan in China+3 种基金the Foundation for the Author of National Excellent Doctoral Dissertation of China,No.201486the Youth Foundation of Science and Technology Department of Sichuan Province in China,No.15QNJJ0008the National Natural Science Foundation-Excellent Youth Foundation in China,No.81622052the 2011 Co-Innovation Center of Sichuan Province named Acupoint Effects of Acupuncture Co-Innovation Center
文摘Acupuncture is widely used to treat functional dyspepsia with satisfactory outcomes. Combination of the He and Mu acupoints is commonly used and has a synergistic effect on functional dyspepsia; however, its underlying mechanisms remain unclear. Therefore, a randomized controlled parallel clinical trial is currently underway at Chengdu University of Traditional Chinese Medicine, China. This trial is designed to explore the efficacy of and central responses to the He-Mu point combination in patients with functional dyspepsia using functional magnetic resonance imaging. A total of 105 patients with functional dyspepsia will be allocated into 3 groups: the low-He point group(puncturing at Zusanli(ST36)), Mu point group(puncturing at Zhongwan(CV12)), and He-Mu point combination group(puncturing at ST36 and CV12). Every participant will receive 20 sessions of manual acupuncture for 4 weeks. The needles will be inserted perpendicularly to a depth of 1 to 2 cun. The angle of rotation and twisting will range from 90 to 180 degrees, while lifting and thrusting will range from 0.3 to 0.5 cm. The various manipulations will be performed 60 to 90 times per minute. The needles will remain in place for 30 minutes, during which manipulation will be applied every 10 minutes. Magnetic resonance imaging will be performed before and after 20 sessions of acupuncture. The primary outcome is symptom improvement according to the Chinese version of the Nepean Dyspepsia Index. Secondary outcomes include the Leeds dyspepsia questionnaire, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Beck Anxiety Inventory, Beck Depression Inventory, and visual analogue scale scores before and after 10 and 20 sessions of acupuncture. Needle sensation and adverse events will be used to assess the therapeutic effects. This study will promote more widespread awareness of the benefits of acupoint combination in the clinical setting and provide a further explanation of the neuromechanism by which acupuncture at the He-Mu point combination for functional dyspepsia. Registration: Chinese Clinical Trial Registry, Chi CTR-IOR-15006402.
基金supported by a grant from the Natural Science Foundation of Anhui Province,China(1408085MKL70)
文摘Background: The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack of randomized control studies. This study aimed to investigate the possible benefit of postoperative adjuvant chemotherapy for resectable cholangiocarcinoma. Data sources: Relevant research articles published before 1 st March 2018 in Pub Med, Embase and the Cochrane library databases were retrieved. Published data were extracted and analyzed by RevMan 5.3, and the results were presented as hazard ratios(HRs) [95% confidence intervals(CI)] and forest plots. Results: One prospective and eighteen retrospective studies were included, with a total number of 11,458 patients, 4696 of whom received postoperative chemotherapy. There was a significant improvement of the overall survival(OS) for patients who underwent operation + adjuvant chemotherapy compared to those who underwent operation alone(HR = 0.61; P < 0.001). Subgroup analyses show that the postoperative chemotherapy group compared with operation alone group are indicated as follows: hilar cholangiocarcinoma group(HR = 0.60; P < 0.001), intrahepatic cholangiocarcinoma group(HR = 0.60; P < 0.001), R1 resection group(HR = 0.71; P = 0.04), LN-positive diagnosis group(HR = 0.58; P < 0.001), gemcitabine-based chemotherapy group(HR = 0.42; P < 0.001), distal cholangiocarcinoma group(HR = 0.48; P = 0.17), R0 resection group(HR = 0.69; P = 0.43), and 5-flurouracil-based chemotherapy group(HR = 0.90; P = 0.66), respectively. Conclusions: Postoperative adjuvant chemotherapy can improve the OS in intrahepatic and hilar cholangiocarcinoma patients. However, distal cholangiocarcinoma patients gain no benefit from postoperative adjuvant chemotherapy. Prospective randomized trials are warranted in order to define the standard chemotherapy regimen.
基金Supported by Special Project for Developing National Major Scientific Instruments and Equipments (2011YQ060111)Scientific Research Project of Environmental Protection in Commonweal Industry(201009032)
文摘[Objective]The study aimed at evaluating the ability to save energy and reduce CO 2 emission in China's cement industry.[Method] Based on long-term energy alternative planning system software(LEAP)," LEAP of China's cement industry" model was established to simulate energy conservation and emission reduction in China's cement industry from 2010 to 2040 in different technologic situations.[Result]To save energy and reduce CO 2 emissions,new dry process kiln has priority over other technologies or measures,followed by equipment enlargement,mechanical shaft kiln,power generation system based on waste heat,as well as high-efficiency and energy-saving grinding technology,and new preparation technology.If all the advanced technologies and measures are adopted,energy consumption and CO 2 emissions can be reduced by about 40.76% and 42.97% respectively.[Conclusion]LEAP of model is suitable for analyzing energy saving and emission reducing in China's cement industry and other industrial fields.
文摘In recent years,the discovery of the Jurassic oil reservoirs in the Western Thrust Belt of the Ordos Basin reveals that the Jurassic formation in this area has huge oil and gas potential.The pre-Jurassic paleo-geomorphology plays a vital role in the formation of the Jurassic oil reservoirs.In this paper,the impression method is applied to restore the pre-Jurassic paleogeomorphology of the Hongde area in the western Ordos Basin,using a large number of drilling,logging,well testing and the latest 3D seismic data.The pre-Jurassic paleogeomorphological units in the study area can be categorized into five groups,including ancient channel valley,ancient terrace,slope,interchannel mound,and low residual mound facies.The oil reservoirs are mainly distributed in highland areas such as slope belts and low residual mounds,the main areas where hydrocarbons accumulate.In addition,the branch ditches in the study area are developed to the southeast and merged into the Ganshan ancient channel.The sandstone in the confluence area of the branch gully is well sorted and connected under frequent scouring by the river.The sand bodies of good connectivity therefore form a drainage system for long-term hydrocarbon migration.The formation of the Jurassic reservoirs in the study area is mainly affected by sedimentary facies,deposition location,and hydrocarbon migration pathway(or fault)of pre-Jurassic paleo-morphology.The results from this study can be useful for the prediction of the Jurassic sweet spots in the western margin of the Ordos Basin.
基金This research was funded by the National Key Research and Development Projects,Grant Number 2018YFE0207800the National Natural Science Foundation of China,Grant Number 41871103.
文摘The decomposition of coarse woody debris(CWD)affects the energy flow and nutrient cycling in forest ecosystems.Previous studies on CWD have focused on the input,decomposition,reserve dynamics,and CWD functions,but coarse woody debris decomposition is complex and the results from different regions vary considerably.It is not clear which factors affect decay rate(k),especially at different decomposition stages.In this study,a single-exponential decay model was used to analyze the characteristics of CWD decomposition in Larix gmelinii forests over the 33 years following a fire in the Greater Khingan Mountains.The results show that the decay rate of coarse woody debris was positively correlated to decay class.The average decomposition rate was 0.019,and 41 years and 176 years are needed for a 50%and 95%mass loss,respectively.CWD nutrient content,density,and water content could explain the variance in the decay rate(~42%)of the decay factors such as amount of leaching,degree of fragmentation,respiration of the debris,and biotransformation,and varied significantly between different decay classes.Using the space-time substitution method,this study arranged the coarse woody debris of different mortality times to form a 33 year chronosequence which revealed the decomposition process.It was concluded that the decay rate was mainly explained by structural component of the debris and its nitrogen and water contents.This paper quantifies the indicators affecting CWD decay to explain the decomposition process.
基金Supported by the National Natural Science Foundation of China(Grant No.11575297).
文摘Symmetry breaking plays a pivotal role in modern physics.Although self-similarity is also a symmetry,and appears ubiquitously in nature,a fundamental question arises as to whether self-similarity breaking makes sense or not.Here,by identifying an important type of critical fluctuation,dubbed‘phases fluctuations’,and comparing the numerical results for those with self-similarity and those lacking self-similarity with respect to phases fluctuations,we show that self-similarity can indeed be broken,with significant consequences,at least in nonequilibrium situations.We find that the breaking of self-similarity results in new critical exponents,giving rise to a violation of the well-known finite-size scaling,or the less well-known finite-time scaling,and different leading exponents in either the ordered or the disordered phases of the paradigmatic Ising model on two-or three-dimensional finite lattices,when subject to the simplest nonequilibrium driving of linear heating or cooling through its critical point.This is in stark contrast to identical exponents and different amplitudes in usual critical phenomena.Our results demonstrate how surprising driven nonequilibrium critical phenomena can be.The application of this theory to other classical and quantum phase transitions is also anticipated.
文摘Carbon dioxide (CO<sub>2</sub>) is one of the most important greenhouse gases;its concentration and distribution have important implications on climate change. The El Ni?o Southern Oscillation (ENSO) is the Earth’s strongest climate fluctuation on inter-annual time scales and has global impacts. However, to date, there is no research on how ENSO affects the spatial distribution of CO<sub>2</sub> concentration. In this study, we used spatial CO<sub>2</sub> data from the ENVIronmentSATellite (ENVISAT) and the Greenhouse Gases Observing Satellite (GOSAT), the long duration monthly mean atmospheric CO<sub>2</sub> from Mauna Loa Observatory, Multivariate ENSO Index (MEI) from Earth System Research Laboratory to analyze the way that ENSO affects spatial distribution of CO<sub>2</sub> concentration in South America, which is affected by ENSO seriously. Our research revealed that monthly CO<sub>2</sub> growth rate has a moderate, positive correlation relationship with MEI. We used geostatistics to predict and simulate the spatial distribution of CO<sub>2</sub> and found that in south of 12°S, CO<sub>2</sub> concentration of ENSO warm episode is lower than the one of ENSO cold and neutral episodes. ENSO impacts CO<sub>2</sub> spatial distribution mainly in November, December, January and February;moderate-high concentration zone of ENSO warm episode more concentrates in the northern part of South America.
文摘The theoretical relationship between water injection multiple(i.e.injected pore volume)and water saturation is inferred from theoretical concepts of reservoir engineering.A mathematical model based on core displacement tests is established for the entire injection process that satisfies both initial displacement and extreme displacement,simultaneously.The results show that prior to the flooding,the water injection multiple has a linear relationship with the water saturation,and the utilization rate of the injected water is the highest.As water breakthrough at the production end,the water-cut increases,and the injection multiple increases exponentially while the utilization efficiency of the injected water gradually decreases.When the injection multiple approaches infinity,the utilization efficiency of the injected water gradually decreases to 0,by which time the water-cut at the production end is always 1.At this time,the water saturation no longer changes,and the water flooding recovery rate reaches its limit.Based on the experimental test data,a mathematical model of the entire process of injection multiple and water saturation is established,which has high fitting accuracy that can predict the injection multiple in the different stages of development of a mature oil reservoir.The dynamically changing index of the injection water utilization efficiency in reservoir development by reactive water flooding can be obtained through reasonable transformation of the mathematical model.This is of great significance in guiding evaluations of the effects of reservoir development and formulating countermeasures.
文摘Unconventional resources will significantly add to the petro-leum reserves and their contribution to global gas/oil production is expected to increase to 25%over the next two decades.However,unconventional reservoirs of coal methane,shale gas,tight sand-stone gas and gas hydrate have complex pore structures and are typically tight with porosity and permeability much lower than conventional reservoirs(Pang et al.,2022;Yin et al.,2018a,2018b).The characterization of the pore structure and the study of micro-scale multiphase flow mechanism are extremely impor-tant for the understanding of unconventional reservoirs.Recent studies show that emerging methodologies have become the most powerful in characterizing the dynamics of liquids in porous media from the nano-pore to fracture scale.
基金financially supported by the International Cooperation Project of National Natural Science Foundation of China(Grant No.81810001048)the National Natural Science Foundation of China(Grant Nos.81922039,81873994,82225027,and 82202702)+1 种基金Key basic research projects of Shanghai Science and Technology Commission(Grant No.19JC141470)the Fundamental Research Funds for the Central Universities of China.
文摘Spinal cord injury triggers complex pathological cascades,resulting in destructive tissue damage and incomplete tissue repair.Scar formation is generally considered a barrier for regeneration in the central nervous system.However,the intrinsic mechanism of scar formation after spinal cord injury has not been fully elucidated.Here,we report that excess cholesterol accumulates in phagocytes and is inefficiently removed from spinal cord lesions in young adult mice.Interestingly,we observed that excessive cholesterol also accumulates in injured peripheral nerves but is subsequently removed by reverse cholesteroltransport.Meanwhile,preventing reverse cholesterol transport leads to macrophage accumulation and fibrosis in injured peripheral nerves.Furthermore,the neonatal mouse spinal cord lesions are devoid of myelin-derived lipids and can heal without excess cholesterol accumulation.We found that transplantation of myelin into neonatal lesions disrupts healing with excessive cholesterol accumulation,persistent macrophage activation,and fibrosis.Myelin internalization suppresses macrophage apoptosis mediated by CD5L expression,indicating that myelin-derived cholesterol plays a critical role in impaired wound healing.Taken together,our data suggest that the central nervous system lacks an efficient approach for cholesterol clearance,resulting in excessive accumulation of myelin-derived cholesterol,thereby inducing scar formation after injury.