BACKGROUND: Ultrasound-guided transversus abdominis plane (TAP) block is an adjunct therapy to provide effective postoperative analgesia in abdominal surgical procedures. Dexamethasone is a supplement agent that can i...BACKGROUND: Ultrasound-guided transversus abdominis plane (TAP) block is an adjunct therapy to provide effective postoperative analgesia in abdominal surgical procedures. Dexamethasone is a supplement agent that can improve the efifcacy of local anesthesia. However, information about its additive effect is limited. This study aimed to compare the an-algesic efifciency using ultrasound-guided TAP block with and without perineural dexamethasone for patients who under-went laparoscopic cholecystectomy. METHODS: Sixty patients who underwent laparoscopic cho-lecystectomy were randomly divided into three groups: group I, controls; group II, TAP; and group III, TAP+perineural dexamethasone supplement. The requirement of additional analgesia and the ifrst-time request of rescue-analgesia were recorded after operation and the numerical rating scale was evaluated at speciifc intervals. RESULTS: Compared to group I, the ifrst-time requirement of rescue-analgesia in groups II and III was signiifcantly delayed (403.0±230.9, 436.0±225.3 vs 152.3±124.7,P<0.01). Compared with those in group I, patients in groups II and III were associ-ated with lower numerical rating scale pain scores (P<0.01) and less postoperative analgesic consumption (P<0.01). There was no signiifcant difference in the variables mentioned above between groups II and III (P>0.05). CONCLUSION: Perineural dexamethasone has no additive/synergistic effect with subcostal TAP block on analgesic efif-cacy for the patients undergoing laparoscopic cholecystectomy.展开更多
文摘BACKGROUND: Ultrasound-guided transversus abdominis plane (TAP) block is an adjunct therapy to provide effective postoperative analgesia in abdominal surgical procedures. Dexamethasone is a supplement agent that can improve the efifcacy of local anesthesia. However, information about its additive effect is limited. This study aimed to compare the an-algesic efifciency using ultrasound-guided TAP block with and without perineural dexamethasone for patients who under-went laparoscopic cholecystectomy. METHODS: Sixty patients who underwent laparoscopic cho-lecystectomy were randomly divided into three groups: group I, controls; group II, TAP; and group III, TAP+perineural dexamethasone supplement. The requirement of additional analgesia and the ifrst-time request of rescue-analgesia were recorded after operation and the numerical rating scale was evaluated at speciifc intervals. RESULTS: Compared to group I, the ifrst-time requirement of rescue-analgesia in groups II and III was signiifcantly delayed (403.0±230.9, 436.0±225.3 vs 152.3±124.7,P<0.01). Compared with those in group I, patients in groups II and III were associ-ated with lower numerical rating scale pain scores (P<0.01) and less postoperative analgesic consumption (P<0.01). There was no signiifcant difference in the variables mentioned above between groups II and III (P>0.05). CONCLUSION: Perineural dexamethasone has no additive/synergistic effect with subcostal TAP block on analgesic efif-cacy for the patients undergoing laparoscopic cholecystectomy.
