Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthri...Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthritis,have strengths and weaknesses.New imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of arthritis.As an emerging nonintrusive low-cost imaging method,microwave-induced thermoacoustic imaging(TAI)can present tissue morphology while providing the tissue microwave energy absorption density distribution related to dielectric properties.TAI is currently in development to potentially visualize joint anatomic structures and to detect arthritis.Here,we offer a mini review to summarize the status of research on TAI of joints and present an outlook to the future development of TAI in the detection of joint diseases.展开更多
It seems that the wealth of information revealed by the multi-messenger observations of the binary neutron star(NS)merger event,GW170817/GRB 170817A/kilonova AT2017gfo,places irreconcilable constraints to models of th...It seems that the wealth of information revealed by the multi-messenger observations of the binary neutron star(NS)merger event,GW170817/GRB 170817A/kilonova AT2017gfo,places irreconcilable constraints to models of the prompt emission of this gamma-ray burst(GRB).The observed time delay between the merger of the two NSs and the trigger of the GRB and the thermal tail of the prompt emission can hardly be reproduced by these models simultaneously.We argue that the merger remnant should be an NS(last for,at least,a large fraction of 1 s),and that the difficulty can be alleviated by the delayed formation of the accretion disk due to the absorption of high-energy neutrinos emitted by the NS and the delayed emergence of effective viscosity in the disk.Further,we extend the consideration of the effect of the energy deposition of neutrinos emitted from the NS.If the NS is the central object of a GRB with a distance and duration similar to that of GRB 170817A,thermal emission of the thermal bubble inflated by the NS after the termination of accretion may be detectable.If our scenario is verified,it would be of interest to investigate the cooling of nascent NSs.展开更多
The fast radio burst,FRB 171019,was relatively bright when discovered first by ASKAP but was identified as a repeater with three faint bursts detected later by GBT and CHIME.These observations lead to the discussion o...The fast radio burst,FRB 171019,was relatively bright when discovered first by ASKAP but was identified as a repeater with three faint bursts detected later by GBT and CHIME.These observations lead to the discussion of whether the first bright burst shares the same mechanism with the following repeating bursts.A model of binary neutron star merger is proposed for FRB 171019,in which the first bright burst occurred during the merger event,while the subsequent repeating bursts are starquake-induced,and generally fainter,as the energy release rate for the starquakes can hardly exceed that of the catastrophic merger event.This scenario is consistent with the observation that no later burst detected is as bright as the first one.展开更多
Indoor microorganisms impact asthma and allergic rhinitis(AR),but the associated microbial taxa often vary extensively due to climate and geographical variations.To provide more consistent environmental assessments,ne...Indoor microorganisms impact asthma and allergic rhinitis(AR),but the associated microbial taxa often vary extensively due to climate and geographical variations.To provide more consistent environmental assessments,new perspectives on microbial exposure for asthma and AR are needed.Home dust from 97 cases(32 asthma alone,37 AR alone,28 comorbidity)and 52 age-and gender-matched controls in Shanghai,China,were analyzed using high-throughput shotgun metagenomic sequencing and liquid chromatography-mass spectrometry.Homes of healthy children were enriched with environmental microbes,including Paracoccus,Pseudomonas,and Psychrobacter,and metabolites like keto acids,indoles,pyridines,and flavonoids(astragalin,hesperidin)(False Discovery Rate<0.05).A neural network co-occurrence probability analysis revealed that environmental microorganisms were involved in producing these keto acids,indoles,and pyridines.Conversely,homes of diseased children were enriched with mycotoxins and synthetic chemicals,including herbicides,insecticides,and food/cosmetic additives.Using a random forest model,characteristic metabolites and microorganisms in Shanghai homes were used to classify high and low prevalence of asthma/AR in an independent dataset in Malaysian schools(N=1290).Indoor metabolites achieved an average accuracy of 74.9%and 77.1%in differentiating schools with high and low prevalence of asthma and AR,respectively,whereas indoor microorganisms only achieved 51.0%and 59.5%,respectively.These results suggest that indoor metabolites and chemicals rather than indoor microbiome are potentially superior environmental indicators for childhood asthma and AR.This study extends the traditional risk assessment focusing on allergens or air pollutants in childhood asthma and AR,thereby revealing potential novel intervention strategies for these diseases.展开更多
基金supported by the National Natural Science Foundation of China under Grant No.62001075the Chinese Postdoctoral Science Foundation under Grant No.2022MD723722+1 种基金the Chongqing Postdoctoral Research Project under Grant No.2021XM2026the Scientific and Technological Research Program of Chongqing Municipal Education Commission under Grant No.KJQN202000610.
文摘Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthritis,have strengths and weaknesses.New imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of arthritis.As an emerging nonintrusive low-cost imaging method,microwave-induced thermoacoustic imaging(TAI)can present tissue morphology while providing the tissue microwave energy absorption density distribution related to dielectric properties.TAI is currently in development to potentially visualize joint anatomic structures and to detect arthritis.Here,we offer a mini review to summarize the status of research on TAI of joints and present an outlook to the future development of TAI in the detection of joint diseases.
基金the National SKA Program of China(2020SKA0120100)research projects of Henan Science and Technology Committee(212300410378)the National NaturalScience Foundationof China(NSFC)grant(U1938116).
文摘It seems that the wealth of information revealed by the multi-messenger observations of the binary neutron star(NS)merger event,GW170817/GRB 170817A/kilonova AT2017gfo,places irreconcilable constraints to models of the prompt emission of this gamma-ray burst(GRB).The observed time delay between the merger of the two NSs and the trigger of the GRB and the thermal tail of the prompt emission can hardly be reproduced by these models simultaneously.We argue that the merger remnant should be an NS(last for,at least,a large fraction of 1 s),and that the difficulty can be alleviated by the delayed formation of the accretion disk due to the absorption of high-energy neutrinos emitted by the NS and the delayed emergence of effective viscosity in the disk.Further,we extend the consideration of the effect of the energy deposition of neutrinos emitted from the NS.If the NS is the central object of a GRB with a distance and duration similar to that of GRB 170817A,thermal emission of the thermal bubble inflated by the NS after the termination of accretion may be detectable.If our scenario is verified,it would be of interest to investigate the cooling of nascent NSs.
基金supported by the Mo ST Grant(2016YFE0100300)the National Key R&D Program of China(2017YFA0402602)+2 种基金NSFC(11633004,11473044,11653003,11673002 and U1531243)the Strategic Priority Research Program of CAS(XDB23010200)the CAS grants(QYZDJSSW-SLH017 and CAS XDB 23040100)。
文摘The fast radio burst,FRB 171019,was relatively bright when discovered first by ASKAP but was identified as a repeater with three faint bursts detected later by GBT and CHIME.These observations lead to the discussion of whether the first bright burst shares the same mechanism with the following repeating bursts.A model of binary neutron star merger is proposed for FRB 171019,in which the first bright burst occurred during the merger event,while the subsequent repeating bursts are starquake-induced,and generally fainter,as the energy release rate for the starquakes can hardly exceed that of the catastrophic merger event.This scenario is consistent with the observation that no later burst detected is as bright as the first one.
基金The study was funded by the National Natural Science Foundation of China(No.81861138005)the Natural Science Foundation of Guangdong Province(Nos.2020A1515010845 and 2021A1515010492)+1 种基金the Science and Technology Program of Guangzhou(No.202102080362)Shanghai B&R Joint Laboratory(No.22230750300)and the Swedish Research Council(Vetenskapsrådet)project(No.2017-05845).
文摘Indoor microorganisms impact asthma and allergic rhinitis(AR),but the associated microbial taxa often vary extensively due to climate and geographical variations.To provide more consistent environmental assessments,new perspectives on microbial exposure for asthma and AR are needed.Home dust from 97 cases(32 asthma alone,37 AR alone,28 comorbidity)and 52 age-and gender-matched controls in Shanghai,China,were analyzed using high-throughput shotgun metagenomic sequencing and liquid chromatography-mass spectrometry.Homes of healthy children were enriched with environmental microbes,including Paracoccus,Pseudomonas,and Psychrobacter,and metabolites like keto acids,indoles,pyridines,and flavonoids(astragalin,hesperidin)(False Discovery Rate<0.05).A neural network co-occurrence probability analysis revealed that environmental microorganisms were involved in producing these keto acids,indoles,and pyridines.Conversely,homes of diseased children were enriched with mycotoxins and synthetic chemicals,including herbicides,insecticides,and food/cosmetic additives.Using a random forest model,characteristic metabolites and microorganisms in Shanghai homes were used to classify high and low prevalence of asthma/AR in an independent dataset in Malaysian schools(N=1290).Indoor metabolites achieved an average accuracy of 74.9%and 77.1%in differentiating schools with high and low prevalence of asthma and AR,respectively,whereas indoor microorganisms only achieved 51.0%and 59.5%,respectively.These results suggest that indoor metabolites and chemicals rather than indoor microbiome are potentially superior environmental indicators for childhood asthma and AR.This study extends the traditional risk assessment focusing on allergens or air pollutants in childhood asthma and AR,thereby revealing potential novel intervention strategies for these diseases.
