Accurate resection of hilar cholangiocarcinoma using eOrganmap 3D reconstruction and full quantization technique

BACKGROUND For treatment of hilar cholangiocarcinoma(HCCA),the rate of radical resection is low and prognosis is poor,and preoperative evaluation is not sufficiently accurate.3D visualization has the advantage of giving a stereoscopic view,which makes accurate resection of HCCA possible.AIM To establish precise resection of HCCA based on eOrganmap 3D reconstruction and full quantification technology.METHODS We retrospectively analyzed the clinical data of 73 patients who underwent HCCA surgery.All patients were assigned to two groups.The traditional group received traditional 2D imaging planning before surgery(n=35).The eOrganmap group underwent 3D reconstruction and full quantitative technical planning before surgery(n=38).The preoperative evaluation,anatomical classification of hilar hepatic vessels,indicators associated with surgery,postoperative complications,liver function,and stress response indexes were compared between the groups.RESULTS Compared with the traditional group,the amount of intraoperative blood loss in the eOrganmap group was lower,the operating time and postoperative intestinal ventilation time were shorter,and R0 resection rate and lymph node dissection number were higher(P<0.05).The total complication rate in the eOrganmap group was 21.05%compared with 25.71%in the traditional group(P>0.05).The levels of total bilirubin,Albumin(ALB),aspartate transaminase,and alanine transaminase in the eOrganmap group were significantly different from those in the traditional group(intergroup effect:F=450.400,79.120,95.730,and 13.240,respectively;all P<0.001).Total bilirubin,aspartate transaminase,and alanine transaminase in both groups showed a decreasing trend with time(time effect:F=30.270,17.340,and 13.380,respectively;all P<0.001).There was an interaction between patient group and time(interaction effect:F=3.072,2.965,and 2.703,respectively;P=0.0282,0.032,and 0.046,respectively);ALB levels in both groups tended to increase with time(time effect:F=22.490,P<0.001),and there was an interaction effect between groups and time(interaction effect:F=4.607,P=0.004).In the eOrganmap group,there was a high correlation between the actual volume of intraoperative liver specimen resection and the volume of preoperative virtual liver resection(t=0.916,P<0.001).CONCLUSION The establishment of accurate laparoscopic resection of hilar cholangiocarcinoma based on preoperative eOrganmap 3D reconstruction and full quantization technology can make laparoscopic resection of hilar cholangiocarcinoma more accurate and safe.

Rechargeable Aqueous Zinc-Ion Batteries in MgSO4/ZnSO4 Hybrid Electrolytes

MgSO4 is chosen as an additive to address the capacity fading issue in the rechargeable zinc-ion battery system of MgxV2O5·nH2O//ZnSO4//zinc.Electrolytes with different concentration ratios of ZnSO4 and MgSO4 are investigated.The batteries measured in the 1 M ZnSO4^-1 M MgSO4 electrolyte outplay other competitors,which deliver a high specific capacity of 374 mAh g^-1 at a current density of 100 mA g^-1 and exhibit a competitive rate performance with the reversible capacity of 175 mAh g^-1 at 5 A g^-1.This study provides a promising route to improve the performance of vanadium-based cathodes for aqueous zinc-ion batteries with electrolyte optimization in cost-effective electrolytes.

新媒体时代短视频的著作权保护策略研究

网络短视频作为新媒体时代下传播中的黑马,逐渐形成明确、可持续的盈利模式,用户黏性不断增强,快速占据大量的市场份额,成为大众日常消遣时光的主要形式。但因其传播效果的短暂性和流动的快捷性,加之其发展的迅速性,愈加严重的侵权问题很快浮出水面,何类网络短视频能够构成类似摄制电影的方法创作的作品并应该受著作权法的保护很快成为争论的焦点,加强网络短视频的著作权保护刻不容缓。

Boosting Sodium Storage of Fe1?xS/MoS2 Composite via Heterointerface Engineering

Improving the cycling stability of metal sulfide-based anode materials at high rate is of great significance for advanced sodium ion batteries.However,the sluggish reaction kinetics is a big obstacle for the development of high-performance sodium storage electrodes.Herein,we have rationally engineered the heterointerface by designing the Fe1?xS/MoS2 heterostructure with abundant“ion reservoir”to endow the electrode with excellent cycling stability and rate capability,which is proved by a series of in and ex situ electrochemical investigations.Density functional theory calculations further reveal that the heterointerface greatly decreases sodium ion diffusion barrier and facilitates charge-transfer kinetics.Our present findings not only provide a deep analysis on the correlation between the structure and performance,but also draw inspiration for rational heterointerface engineering toward the next-generation high-performance energy storage devices.

SYNTHESIS OF PERFLUORO-1-OCTANESULFONATED FULLERENE AND THE FRICTION PROPERTIES OF ITS THIN FILM

A star-shaped compound of perfluoro-1-octanesulfonated fullerene was synthesized. The measurement of the friction for its spin-coating film by friction force microscopy (FFM) reveals that the films possess lower friction force compared to that of the star-shaped C-60-polystyrene films.

Novel microfluidic device for measurable residual disease detection in acute leukemia

Relapse is the most important cause of treatment failure in acute leukemia(AL).Thus,how to predict relapse is critical for improving the survival of patients with AL.Measurable residual diseases(MRDs;previously termed minimal resid-ual diseases),refering to the presence of remaining leukemia cells after the declaration of complete remission(CF)detected by morphological analysis,is the most important biomarker forrelapseprediction.'Several methods,including multiparameter flow cytometry(MFC),real-time quantitative polymerase dhain reaction(qPCR),digital PCR(dPCR),and next-generation sequencing(NGS),are used to monitor MRD after treatment,reaching a sensitvityof 10^(-4)to 10^(-6).

Treatment options for adult intermediate-risk AML patients in CR1:Allo-HSCT or chemotherapy?

Acutemyeloid leukemia(AML),which is the most common form of acute leukemia in adults,is a heterogeneous,clonal hematopoietic disorder characterized by the accumulation of immature myeloid progenitors.This heterogeneity is especially obvious in the“intermediate-risk group”as defined by international criteria such as those of the European LeukemiaNet,Medical Research Council(MRC),and National Comprehensive Cancer Network.

纳西族民族医药传承与保护问题研究

纳西族民族医药作为当地少数民族智慧的结晶,是我国传统民族医药的重要组成部分,具有极高的保护价值。但是,纳西族民族医药文化传承及其医药产业不仅受到药物资源减少的冲击,发展过程中其知识产权被侵害的情形也时有发生,大量优秀的民族医药文化面临流失、流传的困境。要维系纳西族民族医药的可持续发展,应该运用专利、商标、商业秘密等知识产权法律制度进行综合保护,建立起科学的传承与发展系统,使纳西族民族医药成为地方特色支柱产业之一。

Occurrence and impact of polychlorinated dibenzo-p-dioxins/dibenzofurans in the air and soil around a municipal solid waste incinerator

To assess the influence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans（PCDD/Fs） on the environment in the vicinity of municipal solid waste incinerators（MSWIs）, we determined the levels of PCDD/Fs in air and soil samples collected around a MSWI, which is the largest in China. The International Toxicity Equivalency Quantity（I-TEQ） concentrations of PCDD/Fs in air samples were from 0.0300 to 1.03 pg I-TEQ/m^3（0.445–13.6 pg/m^3）, with an average of 0.237 pg I-TEQ/m^3, while in soil samples they ranged from 0.520 to 3.40 pg I-TEQ/g（2.41–88.7 pg/g） with an average of1.49 pg I-TEQ/g. The concentrations of PCDD/Fs in air and soil samples were comparable to other areas, and Pe CDFs were the dominant contributors, which was different from stack gas homologue patterns. Multivariate statistical analysis showed that PCDD/Fs emission from the MSWI did not directly affect the profiles of PCDD/Fs in air and soils, so that vehicles and unidentified emission sources should be considered. The daily inhalation levels of PCDD/Fs for children（0.0110 to 0.392 pg I-TEQ/（kg·day） and adults（0.00600 to 0.221 pg I-TEQ/（kg·day） near the MSWI were lower than the tolerable daily intake of 1.00 to 4.00 pg WHO-TEQ/（kg·day）, but in winter the values were higher than in summer. These results can be used as basic data for assessing the risk of PCDD/Fs exposure in residents living around this MSWI, and more monitoring programs and studies should be carried out around MSWIs.