肺癌根治术中胸膜腔冲洗液肿瘤细胞检查的研究进展

非小细胞肺癌(non-small cell lung cancer, NSCLC)根治术中胸腔冲洗液细胞学检查是一种常用的检测肿瘤进展并评估患者预后的诊断技术。长期以来大量研究者致力于阐明术中胸腔冲洗液细胞学检查结果与肺癌患者术后生存及肿瘤复发转移的关系。由于不同研究间存在明显异质性,其结论也各有不同。但能肯定的是,胸腔冲洗液肿瘤细胞检查阳性已被证实为手术患者的不良预后因素之一。本文尝试从临床意义、影响因素及可能发生机制等角度就近年来术中胸膜腔冲洗的研究进展作一综述。

Properties of long light filaments in natural environment

The multiple filamentation of terawatt femtosecond （fs） laser pulses is experimentally studied in a natural environment. A more than 30-m long plasma filament with a millimeter diameter is formed by the collimated fs laser pulse freely propagating in an open atmosphere. This study provides the first quantitative experimental data about the electron density of a long range light filament in the atmosphere. The electron density of such a filament is quantitatively detected by using an electric method, showing that it is at the 1011-cm -3 level.

Spectral-Phase-Modulated Cross-Polarized Wave for Chirped Pulse Amplifier with High Contrast Ratio

We demonstrate a high-quality cross-polarized-wave filter based on spectral phase modulation. Driven by Well- eompressed spectral-phase fully-compensated fundamental laser lmlses, the filter stretches the pulse bandwidth from 35 nm to 7Ohm with a conversion efficeiency of 20%.

GC-MS Analysis of Chemical Constituents of Volatile Oils of the Yao Medicine Thunbergia grandiflora from Different Habitats in Guangxi

[Objectives]This study was conducted to compare and analyze the chemical constituents of the volatile oils of the Yao medicine Thunbergia grandiflora from different habitats.[Methods]A quartz capillary column DB-1MS,an EI ion source and a quadrupole mass analyzer were used for analysis.The chromatographic and mass spectrum information obtained was automatically retrieved and analyzed by data processing system and its memory spectrum library(Nist.08).The relative content of each chemical component in the volatile oil was determined by the peak area normalization method.[Results]Forty nine chromatographic peaks were isolated from the sample produced in Shitun,Bailongtan Town,Mashan County,and 24 chemical constituents were identified,accounting for 88.78% of the total volatile oil.Forty nine chromatographic peaks were isolated from the sample produced in Hongdu Village,Chengjiang Town,Duan County,and 30 chemical constituents were identified,accounting for 88.38% of the total volatile oil.Forty eight chromatographic peaks were isolated from the sample produced in Longwan Township,Du'an County,and 25 chemical constituents were identified,accounting for 80.01% of the total volatile oil.Nine chemical constituents were common to the volatile oils of the samples from the three habitats.[Conclusions]It could be seen that the main components of volatile oils from T.grandiflora produced in different areas are different.

Superior dynamic shear properties by structures with dual gradients in medium entropy alloys

Structures with single gradient and dual gradients have been designed and fabricated in an Al_(0.5)Cr_(0.9)FeNi_(2.5)V_(0.2) medium entropy alloy.Structures with dual gradients(with increasing grain size and a decreasing volume fraction of nanoprecipitates from the surface to the center)were observed to show much better dynamic shear properties compared to both structures with single grainsize gradient and coarse-grained structures with homogeneously distributed nanoprecipitates.Thus,the dual gradients have a synergetic strengthening/toughening effect as compared to the sole effect of a single gradient and the sole precipitation effect.Initiation of the adiabatic shear band(ASB)is delayed and propagation of ASB is slowed down in structures with dual gradients compared to structures with single gradients,resulting in better dynamic shear properties.A higher magnitude of strain gradient and higher density of geometrically necessary dislocations are induced in the structures with dual gradients,resulting in extra strain hardening.Higher density dislocations,stacking faults,and Lomer-Cottrell locks can be accumulated by the interactions between these defects and B2/L1_(2) precipitates,due to the higher volume fraction of nanoprecipitates in the surface layer of the structures with dual gradients,which could retard the early strain localization in the surface layer for better dynamic shear properties.

The role of gut microbiota in immune checkpoint inhibitor therapy

It has been well established that the gut microbiota has a substantial influence on the host immune system.By crosstalk between specific microorganism-associated molecular patterns and the immune system,in addition to bacterial metabolic activity,gut microbiota regulates local or systemic inflammation(1).Recently,the composition of gut microbiota has been presumed to be one of the factors affecting the cancer-immune set point of cancer patients,which subsequently determines the efficacy of immune checkpoint inhibitor(ICI)treatment(2).