Radiation therapy(RT)that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment method.However,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the t...Radiation therapy(RT)that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment method.However,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the tumor.Using high atom number(Z)element-based radio sensitizers to increase energy deposit inside tumor cells can achieve better carcinoma killing.Tantalum nanoparticles(Ta NPs)exhibit good radiotherapy sensitization effects.However,achieving the water solubility of Ta NPs is challenging.This study reported a mechanochemical method for obtaining Ta NPs modified with sodium hexametaphosphate(SHMP)for radiotherapy sensitization applications.The results showed that the water solubility of Ta NPs modified with SHMP was significantly improved.Their biocompatibility and radio sensitizing ability are also verified at both cellular and animal levels.展开更多
基金supported by the National Key R&D Program of China(Nos.2020YFA0710702 and 2021YFA1201200)the National Science Foundation of China(Nos.22375205,51705295 and 52103337)+3 种基金Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)Directional Institutionalized Scientific Research Platform relies on Beijing Synchrotron Radiation Facility of Chinese Academy of Sciences,Beijing Natural Science Foundation(No.2222087)Shandong Provincial Natural Science Foundation of China(ZR2022ME032)the Support Program for Youth Innovation Technology in Colleges and Universities of Shandong Province(2019KJB015)。
文摘Radiation therapy(RT)that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment method.However,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the tumor.Using high atom number(Z)element-based radio sensitizers to increase energy deposit inside tumor cells can achieve better carcinoma killing.Tantalum nanoparticles(Ta NPs)exhibit good radiotherapy sensitization effects.However,achieving the water solubility of Ta NPs is challenging.This study reported a mechanochemical method for obtaining Ta NPs modified with sodium hexametaphosphate(SHMP)for radiotherapy sensitization applications.The results showed that the water solubility of Ta NPs modified with SHMP was significantly improved.Their biocompatibility and radio sensitizing ability are also verified at both cellular and animal levels.
