The patients w让h acquired immunodeficiency syndrome(AIDS)are prone to opportunistic infections due to immune deficiencies.Because the AIDS virus is neuropathic,10%of AIDS patients first manifested central nervous sys...The patients w让h acquired immunodeficiency syndrome(AIDS)are prone to opportunistic infections due to immune deficiencies.Because the AIDS virus is neuropathic,10%of AIDS patients first manifested central nervous system(CNS)symptoms.111 More than 40% of untreated AIDS patients will develop CNS diseases.121 The diagnosis and treatment for AIDS complicated with intracranial lesions are mainly based on clinical experience and laboratory tests.If necessary,brain biopsies were taken into consideration to help to diagnose and choose a suitable therapy.In clinic practice,to get a specific diagnosis is very difficult.To further analyze the clinical features of such patients and to provide some suggestions for the clinical diagnosis and treatments,we retrospectively analyzed three AIDS cases with CNS infection who attended the Peking Union Medical College Hospital.展开更多
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the import...Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.展开更多
文摘The patients w让h acquired immunodeficiency syndrome(AIDS)are prone to opportunistic infections due to immune deficiencies.Because the AIDS virus is neuropathic,10%of AIDS patients first manifested central nervous system(CNS)symptoms.111 More than 40% of untreated AIDS patients will develop CNS diseases.121 The diagnosis and treatment for AIDS complicated with intracranial lesions are mainly based on clinical experience and laboratory tests.If necessary,brain biopsies were taken into consideration to help to diagnose and choose a suitable therapy.In clinic practice,to get a specific diagnosis is very difficult.To further analyze the clinical features of such patients and to provide some suggestions for the clinical diagnosis and treatments,we retrospectively analyzed three AIDS cases with CNS infection who attended the Peking Union Medical College Hospital.
文摘Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.
