Increasing evidence suggests that long non-coding RNAs(lncRNAs)are of vital importance for various biological processes,and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis.Lnc...Increasing evidence suggests that long non-coding RNAs(lncRNAs)are of vital importance for various biological processes,and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis.LncRNAs modulate gene expression at the transcriptional,post-transcriptional,and translational levels;however,the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored.This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis,especially focusing on the role of lncRNAs in keratinocytes,T cells,and dendritic cells.展开更多
基金This work was supported by grants from the National Key Research and Development Program of China(No.2018YFC1705305)the National Natural Science Foundation of China(Nos.81973860,81904214,81671959,U1704171,82004235)+3 种基金Shanghai Development Office of Traditional Chinese Medicine(Nos.ZY(2018-2020)-FWTX-1008,ZY(2018-2020)-CCCX-2004-08,and ZY(2018-2020)-FWTX-4010)Hundred Talents Program of Shaanxi(No.SXBR9053)Science and Technology Commission of Shanghai Municipality(No.18401933500)the Shanghai Key Clinical Specialties Construction Project of Dermatology of Traditional Chinese Medicine(No.shslczdzk05001)。
文摘Increasing evidence suggests that long non-coding RNAs(lncRNAs)are of vital importance for various biological processes,and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis.LncRNAs modulate gene expression at the transcriptional,post-transcriptional,and translational levels;however,the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored.This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis,especially focusing on the role of lncRNAs in keratinocytes,T cells,and dendritic cells.
