Iridium photosensitizer constructed liposomes with hypoxia-activated prodrug to destrust hepatocellular carcinoma

Hypoxic tumor microenvironment is a major challenge for photodynamic therapy(PDT). To overcome this problem, PDT combined hypoxia-activated chemotherapy is a promising strategy for hypoxic cancer therapy. Herein, a multifunctional liposome(AQ4N-Ir1-sorafenib-liposome) is prepared by encapsulating a hypoxia-activated prodrug AQ4N, a photosensitizer iridium(III) complex and hepatocellular carcinoma(HCC) targeting drug sorafenib, for synergistic therapy of HCC. Ir1-mediated PDT upon irradiation induces ROS generation and hypoxic environment, which leads to the disassembly of the liposome and activates the antitumor activity of AQ4N. Meantime, the co-delivered sorafenib could effectively target therapy of HCC. It is noted that ferroptosis mechanism is proved during the treatment. This work contributes to the design of hypoxia-responsive multifunctional liposome for combination of chemotherapy, targeting therapy and PDT. It is a promising strategy for hypoxic HCC therapy.

TOWARD COLLECTIVE INTELLIGENCE OF ONLINE COMMUNITIES:A PRIMITIVE CONCEPTUAL MODEL

Inspired by the ideas of Swarm Intelligence and the ＂global brain＂, a concept of ＂community intelligence＂ is suggested in the present paper, reflecting that some ＂intelligent＂ features may emerge in a Web-mediated online community from interactions and knowledge-transmissions between the community members. This possible research field of community intelligence is then examined under the backgrounds of ＂community＂ and ＂intelligence＂ researches. Furthermore, a conceptual model of community intelligence is developed from two views. From the structural view, the community intelligent system is modeled as a knowledge supernetwork that is comprised of triple interwoven networks of the media network, the human network, and the knowledge network. Furthermore, based on a dyad of knowledge in two forms of ＂knowing＂ and ＂knoware＂, the dynamic view describes the basic mechanics of the formation and evolution of ＂community intelligence＂. A few relevant research issues are shortly discussed on the basis of the proposed conceptual model.

Transanal vs laparoscopic total mesorectal excision for rectal cancer:a multicenter randomized phase III clinical trial(TaLaR trial)protocol

Background:Total mesorectum excision(TME)is considered the standard surgical procedure for rectal-cancer treatment.Transanal TME(taTME)is a new procedure to treat low rectal cancer.Some published studies have proven that taTME can provide a better-quality resected specimen in low-rectal-cancer patients in comparison to the transabdominal procedure,yet long-term outcomes must be investigated.We designed this non-inferiority trial(TaLaR trial)to compare short-term and long-term outcomes between taTME and laparoscopic TME(lapTME)for rectal cancer.Methods:The TaLaR trial is a phase III open-labeled multicenter randomized-controlled trial.Patients who are diagnosed with rectal cancer with no more than T3N2 stage,and with the tumor location below the peritoneal reflection by magnetic resonance imaging scan,digital rectal examination,or colonoscopy,qualify for this study.After calculating,a total of 1,114 patients(557 per group)will be randomly allocated to either the taTME or the lapTME group.Primary endpoints are the 3-year disease-free survival(DFS)rate and the 5-year overall survival(OS)rate.Secondary endpoints include specimen quality,perioperative results,pelvic and anal function,and quality of life.Discussion:The TaLaR trial is expected to clarify whether taTME can achieve comparable oncological outcomes,as well as improve specimen quality and recovery conditions in rectal-cancer patients compared with lapTME.

A COUPLED DYNAMIC MODEL OF BRAND ACCEPTANCE AND PROMOTIVE INFORMATION SPREADING

When people try to decide to buy or not to, they are often influenced by both their inherentopinions and the social marketing activities e.g. advertising, social news with strong point of view.Then people will make their final choice, or even convince other people to buy. After all, this is thebrand acceptance formation process. Factually, the dynamics of brand acceptance is essentially aninterwoven dynamics of endogenous opinion dynamics disturbed by an information diffusion process.To have a better understanding of the dynamics of brand acceptance, we propose and analyze a coupledagent-based dynamic model that combines the Majority-Rule-based Voter model in opinion dynamicswith the SI Model for information spreading to analyze the dynamics of brand acceptance in socialmedia. We focus on two important parameters in diffusion dynamics： the decayed transmission rate （fl）and the diffusion frequency （f）. When the system is stable, the order parameter of the system is theduration time （r）. In the absence of opinion interaction, the simulation results indicate that, when abrand tries to occupy a larger market share through social marketing approaches, it is always effectiveto let the opponent to be the propaganda target. While with the Majority-Rule-based Voter Modelincluded, we observe that the opinion interaction could have a dual function, which shows that a brandholding a small market share in the first place needs to adopt diverse marketing approaches accordingto different marketing environment types.